Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Evguenia M. Alexandrova"'
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-12 (2021)
Abstract While pregnancy is known to reduce a woman’s life-long risk of breast cancer, clinical data suggest that it can specifically promote HER2 (human EGF receptor 2)-positive breast cancer subtype (HER2+ BC). HER2+ BC, characterized by amplific
Externí odkaz:
https://doaj.org/article/dfeb6bf552834d6a94716cb5a385fc34
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-11 (2021)
Abstract Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies h
Externí odkaz:
https://doaj.org/article/73512e32ea094764bdd93fa6d33904f9
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/a897060e2c3046eeb2187ba892eaa0e5
Autor:
Christopher E. Eyermann, Xi Chen, Ozge S. Somuncu, Jinyu Li, Alexander N. Joukov, Jiang Chen, Evguenia M. Alexandrova
The p63 transcription factor is critical for epidermis formation in embryonic development, but its role in the adult epidermis is poorly understood. Here we show that acute genetic ablation of ΔNp63, the main p63 isoform, in adult epidermis disrupts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11268c10e72cb0d40adc6b2c0831c100
https://doi.org/10.1101/2022.08.17.504172
https://doi.org/10.1101/2022.08.17.504172
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 1, Pp 1-11 (2021)
Cell Death and Disease, Vol 12, Iss 1, Pp 1-11 (2021)
Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have great
Autor:
Natalia D. Marchenko, Lucas Garcia, Alisha R. Yallowitz, Evguenia M. Alexandrova, Amr M. Ghaleb
Publikováno v:
Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Despite success of ERBB2-targeted therapies such as lapatinib, resistance remains a major clinical concern. Multiple compensatory receptor tyrosine kinase (RTK) pathways are known to contribute to lapatinib resistance. The heterogeneity of these adap
Autor:
Evguenia M. Alexandrova, Ute M. Moll
Publikováno v:
Cell Death and Differentiation
Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy
Autor:
Evguenia M. Alexandrova, S Xu, Ramona Schulz-Heddergott, Ute M. Moll, Safia A Mirza, Natalia D. Marchenko
Publikováno v:
Cell Death & Disease
Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itse
Autor:
Ute M. Moll, N D Marchenko, Evguenia M. Alexandrova, Alisha R. Yallowitz, S Xu, Flaminia Talos
Publikováno v:
Cell Death & Differentiation. 21:645-654
In embryogenesis, p63 is essential to develop mammary glands. In the adult mammary gland, p63 is highly expressed in the basal cell layer that comprises myoepithelial and interspersed stem/progenitor cells, and has limited expression in luminal epith
Publikováno v:
Cell Death & Disease
The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and ca