Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Evgeny V. Khvatov"'
Autor:
Kseniya N. Sedenkova, Artem S. Sazonov, Dmitry A. Vasilenko, Kristian S. Andriasov, Marina G. Eremenko, Yuri K. Grishin, Evgeny V. Khvatov, Alexander S. Goryashchenko, Victoria I. Uvarova, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Elena B. Averina
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10758 (2023)
Spirocyclic compounds containing heterocyclic moieties represent promising 3D scaffolds for modern drug design. In the search for novel anti-flaviviral agents, we have obtained a series of 3-[N,N-bis(sulfonyl)amino]isoxazolines containing spiro-annul
Externí odkaz:
https://doaj.org/article/1abd5c01074f4c61b5fa0d5b30ff0041
Autor:
Kseniya N. Sedenkova, Victoria I. Uvarova, Anna A. Nazarova, Aleksandra V. Peisikova, Evgeny V. Khvatov, Maksim V. Sukhorukov, Vasilisa S. Frolenko, Alexander S. Goryashchenko, Ivan S. Kholodilov, Yuri K. Grishin, Viktor B. Rybakov, Marat T. Makenov, Evgeny S. Morozkin, Lyudmila S. Karan, Liubov I. Kozlovskaya, Aydar A. Ishmukhametov, Dmitry I. Osolodkin, Elena B. Averina
Publikováno v:
Archiv der Pharmazie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce1ad3bd7ee3df0d540da20337882efa
https://doi.org/10.1002/ardp.202300027
https://doi.org/10.1002/ardp.202300027
Autor:
Mikhail F. Vorovitch, Valeriya R Samygina, Evgeny Pichkur, Peter V Konarev, Georgy Peters, Evgeny V Khvatov, Alla L Ivanova, Ksenia K. Tuchynskaya, Olga I. Konyushko, Anton Y. Fedotov, Grigory Armeev, Konstantin V Shaytan, Filipe R N C Maia, Mikhail V. Kovalchuk, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Alexey M. Egorov
X-ray imaging of virus particles at European XFEL could eventually allow solving their complete structure, potentially approaching resolution of other structural virology methods. To achieve this ambitious goal with today’s technologies, several mL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede1141dfaa65caad0e14080ee417252
https://doi.org/10.1101/2023.01.26.525647
https://doi.org/10.1101/2023.01.26.525647
Autor:
Alexey A. Chistov, Stepan P. Chumakov, Igor E. Mikhnovets, Timofei D. Nikitin, Nikita A. Slesarchuk, Victoria I. Uvarova, Anna A. Rubekina, Yulia V. Nikolaeva, Eugene V. Radchenko, Evgeny V. Khvatov, Alexey A. Orlov, Vasilisa S. Frolenko, Maksim V. Sukhorukov, Ekaterina S. Kolpakova, Elena Y. Shustova, Anastasiya V. Galochkina, Philipp P. Streshnev, Eugene M. Osipov, Ksenia A. Sapozhnikova, Andrey V. Moiseenko, Vladimir A. Brylev, Gleb V. Proskurin, Yuri S. Dokukin, Sergey V. Kutyakov, Andrey V. Aralov, Vladimir A. Korshun, Sergei V. Strelkov, Vladimir A. Palyulin, Aydar A. Ishmukhametov, Evgeny A. Shirshin, Dmitry I. Osolodkin, Anna A. Shtro, Liubov I. Kozlovskaya, Vera A. Alferova, Alexey V. Ustinov
Publikováno v:
Antiviral Research. 209:105508
Amphipathic nucleoside and non-nucleoside derivatives of pentacyclic aromatic hydrocarbon perylene are known as potent non-cytotoxic broad-spectrum antivirals. Here we report 3-methyl-5-(perylen-3-ylethynyl)-uracil-1-acetic acid and its amides, a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb41103ed6709a5665d318635a1b4ac3
https://doi.org/10.1016/j.antiviral.2022.105508
https://doi.org/10.1016/j.antiviral.2022.105508
Autor:
Ksenia A. Sapozhnikova, Dmitry I. Osolodkin, Alexey A. Orlov, Alexey A. Chistov, Vladimir A. Korshun, Vladimir A. Brylev, Nikita A. Slesarchuk, Liubov I. Kozlovskaya, Vladimir A. Palyulin, Eugene V. Radchenko, Alexey V. Ustinov, Evgeny V. Khvatov
Publikováno v:
RSC Advances. 9:26014-26023
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified molecules with high activities against tick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afa2bbceeac38c3122eafbecf444fbb
https://doi.org/10.1039/c9ra06313g
https://doi.org/10.1039/c9ra06313g
Autor:
Anastasiya I. Lazarevich, Gleb V. Proskurin, Artjom V. Jegorov, Aydar Ishmukhametov, Alexey A. Chistov, Vadim V. Shmanai, Dmitry I. Osolodkin, Egor A. Ulashchik, Timofei D. Nikitin, Alexey V. Ustinov, Nikita A. Slesarchuk, Liubov I. Kozlovskaya, Andrey V. Aralov, Anton P. Tyurin, Vladimir A. Korshun, Angelina A. Ulanovskaya, Alexey A. Orlov, Evgeny V. Khvatov
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(10)
Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c1a65de65d803ce47e3cbf03df6b27
https://pubmed.ncbi.nlm.nih.gov/32199731
https://pubmed.ncbi.nlm.nih.gov/32199731
Autor:
Tamara S. Kuznetsova, Alexey A. Orlov, Elena B. Averina, Evgeny V. Khvatov, Kseniya N. Sedenkova, Anna A. Nazarova, Dmitry I. Osolodkin, Vladimir A. Palyulin, Yuri K. Grishin, Evgenia V. Dueva
Publikováno v:
Mendeleev Communications. 28:592-594
Novel N-(1-oxidopyrimidin-4-yl)- and N,N′-bis(1-oxidopyrimidin-4-yl)diamines were prepared from 4-fluoropyrimidine N-oxides and diamines basing on SNAr reaction. One compound from this series possessed antiviral activity against tick-borne encephal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319263154984516f09383a091aea6193
https://doi.org/10.1016/j.mencom.2018.11.009
https://doi.org/10.1016/j.mencom.2018.11.009
Autor:
Alexey A. Orlov, Anastasia A. Eletskaya, Anastasia A. Nikitina, Dragos Horvath, Dmitry I. Osolodkin, Alexandre Varnek, Anastasia D. Zolotareva, Alexander A. Koruchekov, Vladimir A. Palyulin, Liubov I. Kozlovskaya, Evgeny V. Khvatov
Publikováno v:
Molecular Informatics
Molecular Informatics, Wiley-VCH, 2019, 38 (5), pp.1800166. ⟨10.1002/minf.201800166⟩
Molecular Informatics, 2019, 38 (5), pp.1800166. ⟨10.1002/minf.201800166⟩
Molecular Informatics, Wiley-VCH, 2019, 38 (5), pp.1800166. ⟨10.1002/minf.201800166⟩
Molecular Informatics, 2019, 38 (5), pp.1800166. ⟨10.1002/minf.201800166⟩
Recent outbreaks of dangerous viral infections, such as Ebola virus disease, Zika fever, etc., are forcing the search for new antiviral compounds. Preferably, such compounds should possess broad-spectrum antiviral activity, as the development of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d7fb46cc89e2972249171b95798d69
https://hal.archives-ouvertes.fr/hal-02346937
https://hal.archives-ouvertes.fr/hal-02346937
Autor:
Alexander A. Koruchekov, Liubov I. Kozlovskaya, Andrey V. Aralov, Evgeny S. Belyaev, Vladimir A. Korshun, Graciela Andrei, Robert Snoeck, Evgeny N. Nikolaev, Dmitry I. Osolodkin, Evgeny V. Khvatov, Alexey A. Orlov, Elena S. Matyugina
Publikováno v:
Antiviral research. 163
The phenoxazine scaffold is widely used to stabilize nucleic acid duplexes, as a part of fluorescent probes for the study of nucleic acid structure, recognition, and metabolism, etc. Here we present the synthesis of phenoxazine-based nucleoside deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709deebcb0605649ad700d4d39f25e07
https://pubmed.ncbi.nlm.nih.gov/30684562
https://pubmed.ncbi.nlm.nih.gov/30684562