Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Evgeny V, Pavlov"'
Autor:
Renata T. Da Costa, Pedro Urquiza, Matheus M. Perez, YunGuang Du, Mei Li Khong, Haiyan Zheng, Mariona Guitart-Mampel, Pia A. Elustondo, Ernest R. Scoma, Vedangi Hambardikar, Beatrix Ueberheide, Julian A. Tanner, Alejandro Cohen, Evgeny V. Pavlov, Cole M. Haynes, Maria E. Solesio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle. However, the precise molecular composition of these mechanisms remains unclear. Our data show that
Externí odkaz:
https://doaj.org/article/88ee7d20f5ac4d03baa5fa1375c6926b
Autor:
Irina Bukhteeva, Fasih A. Rahman, Brian Kendall, Robin E. Duncan, Joe Quadrilatero, Evgeny V. Pavlov, Michel J. P. Gingras, Zoya Leonenko
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The effects of lithium (Li) isotopes and their impact on biological processes have recently gained increased attention due to the significance of Li as a pharmacological agent and the potential that Li isotopic effects in neuroscience contexts may co
Externí odkaz:
https://doaj.org/article/11afe23110714088a1896c9bbdbe4c7c
Publikováno v:
Актуальные вопросы пожарной безопасности, Vol 11, Iss 1, Pp 23-28 (2022)
The article discusses the issues concerning usage of restored manual fire nozzles for effective extinguishing of forest, grassland, ground and wildland fires. The relevance of the paper is due to the effective use of fire extinguishing agents, as wel
Externí odkaz:
https://doaj.org/article/f50e10ff747149fb9db0083afb53c6ee
Publikováno v:
Cells, Vol 12, Iss 15, p 1950 (2023)
The mitochondrial permeability transition pore (mPTP) is a large, weakly selective pore that opens in the mitochondrial inner membrane in response to the pathological increase in matrix Ca2+ concentration. mPTP activation has been implicated as a key
Externí odkaz:
https://doaj.org/article/ed661614bf9d4eb1b5c64eec753df9ff
Autor:
Giuseppe Federico Amodeo, Brenda Yasie Lee, Natalya Krilyuk, Carina Teresa Filice, Denis Valyuk, Daniel Erik Otzen, Sergey Noskov, Zoya Leonenko, Evgeny V. Pavlov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral part of the F0 complex of the ATP synthase, the c subunit is also present in other cytoplasmic compartments in ceroid li
Externí odkaz:
https://doaj.org/article/b00333c6b7dd491981fe6f05f6206b8b
Autor:
Jasiel O. Strubbe-Rivera, Jason R. Schrad, Evgeny V. Pavlov, James F. Conway, Kristin N. Parent, Jason N. Bazil
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain enigmatic. In the present study, we analyzed a series of time-course experiments to ident
Externí odkaz:
https://doaj.org/article/10be602351054d3e97056f991fc7d5e6
Autor:
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeabi
Externí odkaz:
https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11022 (2021)
The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c subunit from mammalian mitochondria exhibits ion channel activity. In particular, c subunit
Externí odkaz:
https://doaj.org/article/cdbf538fb18649e09b0adb1131301aca
Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex
Autor:
Nelli Mnatsakanyan, Han-A Park, Jing Wu, Xiang He, Marc C. Llaguno, Maria Latta, Paige Miranda, Besnik Murtishi, Morven Graham, Joachim Weber, Richard J. Levy, Evgeny V. Pavlov, Elizabeth A. Jonas
Publikováno v:
Cell Death & Differentiation. 29:1874-1887
Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was suggested to house the leak channel of mitochondrial permeability transition (mPT), which activates du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4741c186f970772952c9a055389a99
https://doi.org/10.1038/s41418-022-00972-7
https://doi.org/10.1038/s41418-022-00972-7
Autor:
Galina D. Mironova, Evgeny V. Pavlov
Publikováno v:
Cells, Vol 10, Iss 1, p 125 (2021)
A sharp increase in the permeability of the mitochondrial inner membrane known as mitochondrial permeability transition (or mPT) occurs in mitochondria under the conditions of Ca2+ and ROS stress. Permeability transition can proceed through several m
Externí odkaz:
https://doaj.org/article/9a5d30ffb4de4a90be93ef32ca575aa7