Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Evgeny Shmelkov"'
Autor:
Mohammed S Aiyegbo, Evgeny Shmelkov, Lorenzo Dominguez, Michael Goger, Shibani Battacharya, Allan C deCamp, Peter B Gilbert, Phillip W Berman, Timothy Cardozo
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170530 (2017)
The only evidence of vaccine-induced protection from HIV acquisition in humans was obtained in the RV144 HIV vaccine clinical trial. One immune correlate of risk in RV144 was observed to be higher titers of vaccine-induced antibodies (Abs) reacting w
Externí odkaz:
https://doaj.org/article/abd1b8611f2343b59eeba8e06791008e
Autor:
Evgeny Shmelkov, Chavdar Krachmarov, Arsen V Grigoryan, Abraham Pinter, Alexander Statnikov, Timothy Cardozo
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89987 (2014)
The extreme diversity of HIV-1 strains presents a formidable challenge for HIV-1 vaccine design. Although antibodies (Abs) can neutralize HIV-1 and potentially protect against infection, antibodies that target the immunogenic viral surface protein gp
Externí odkaz:
https://doaj.org/article/66a77b485f8d461fb0bff52edfddbdcc
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27279 (2011)
A specific response of human serum neutralizing antibodies (nAb) to a conformational epitope as a result of vaccination of human subjects with the surface envelope glycoprotein (gp120) of HIV-1 has not previously been documented. Here, we used comput
Externí odkaz:
https://doaj.org/article/039e3abbdbe04036bc1368685d517d65
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15994 (2010)
Although the sequence variable loops of the human immunodeficiency virus' (HIV-1) surface envelope glycoprotein (gp120) can exhibit good immunogenicity, characterizing conserved (invariant) cross-strain neutralization epitopes within these loops has
Externí odkaz:
https://doaj.org/article/6e20c16504a34733a391d89912cc4788
Publikováno v:
Human Vaccines & Immunotherapeutics. 10:3013-3016
The immune-correlate analysis of the RV144 clinical trial revealed that human plasma IgA immune responses elicited by the RV144 vaccine correlated positively with a risk for HIV acquisition. This result once again emphasized that HIV vaccines can pot
Autor:
James Swetnam, Sergey V. Shmelkov, Evgeny Shmelkov, K Felsovalyi, T Butler, Timothy Cardozo, Dolores Malaspina
Publikováno v:
Translational Psychiatry
The central nervous system is functionally organized as a dynamic network of interacting neural circuits that underlies observable behaviors. At higher resolution, these behaviors, or phenotypes, are defined by the activity of a specific set of biomo
Autor:
Till Milde, Sergey V. Shmelkov, Andrew J. Murphy, Kevin G. Bath, Muhamed Baljevic, David M. Valenzuela, Francis S. Lee, Nicholas W. Gale, Evgeny Shmelkov, Deqiang Jing, Ipe Ninan, Jared S Kushner, George D. Yancopoulos, Iva Dincheva, Adilia Hormigo, Shahin Rafii, Catia C. Proenca
Publikováno v:
Nature Medicine. 16:598-602
Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions, and it often encompasses anxiety and depressive symptoms1,2. Recently, the corticostriatal circuitry
Autor:
Peter B. Gilbert, Shibani Battacharya, Timothy Cardozo, Allan C. deCamp, Evgeny Shmelkov, Michael Goger, Phillip W. Berman, Mohammed S. Aiyegbo, Lorenzo Dominguez
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170530 (2017)
PLoS ONE
PLoS ONE
The only evidence of vaccine-induced protection from HIV acquisition in humans was obtained in the RV144 HIV vaccine clinical trial. One immune correlate of risk in RV144 was observed to be higher titers of vaccine-induced antibodies (Abs) reacting w
Autor:
Alexander Statnikov, Timothy Cardozo, Chavdar Krachmarov, Abraham Pinter, Evgeny Shmelkov, Arsen Grigoryan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89987 (2014)
PLoS ONE, Vol 9, Iss 2, p e89987 (2014)
The extreme diversity of HIV-1 strains presents a formidable challenge for HIV-1 vaccine design. Although antibodies (Abs) can neutralize HIV-1 and potentially protect against infection, antibodies that target the immunogenic viral surface protein gp
Autor:
Timothy Cardozo, Evgeny Shmelkov, Arsen Grigoryan, Alexander Statnikov, C Krachmarov, A Agarwal
Publikováno v:
Retrovirology
Retrovirology, Vol 9, Iss Suppl 2, p P332 (2012)
Retrovirology, Vol 9, Iss Suppl 2, p P332 (2012)
Results We optimized the method for each of the two Abs by determining an optimal docking model (optimal boundaries of a docking peptide and an optimal Ab crystallographic conformation) giving the largest area under the prediction ROC curve (AUC) on