A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Autor: Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779