Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Evgeny N, Imyanitov"'
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 3, Pp 742-765 (2024)
The management of lung cancer (LC) requires the analysis of a diverse spectrum of molecular targets, including kinase activating mutations in EGFR, ERBB2 (HER2), BRAF and MET oncogenes, KRAS G12C substitutions, and ALK, ROS1, RET and NTRK1-3 gene fus
Externí odkaz:
https://doaj.org/article/c036f49bae7a449d9b9773f3d56f4e18
Autor:
Aram A. Musaelyan, Ekaterina M. Anokhina, Alina I. Turdubaeva, Natalia V. Mitiushkina, Anastasia N. Ershova, Anna D. Shestakova, Aigul R. Venina, Evgeny N. Imyanitov, Sergey V. Orlov
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 3, Pp 780-788 (2024)
Systemic chemotherapy is the main treatment option for patients with advanced intrahepatic cholangiocarcinoma (iCCA), however, its efficacy is limited. Herein, we report a young patient with NRAS-mutated chemoresistant metastatic iCCA, who received s
Externí odkaz:
https://doaj.org/article/15c6b988128b481890e948ca980a13a8
Autor:
Alexey V. Emshanov, Denis V. Nesterov, Tatyana N. Sokolova, Priscilla S. Amankwah, Evgeny N. Imyanitov
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 6, Pp 1157-1164 (2023)
Early clinical trials aimed to halt cancer progression by inhibiting the growth of new blood vessels in tumors through single-agent targeted therapy with bevacizumab. These trials largely proved unsuccessful. However, bevacizumab turned out to be eff
Externí odkaz:
https://doaj.org/article/f40cd9ad4fa841f1825c8283ad455897
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9335 (2024)
There are more than 260 million people of Slavic descent worldwide, who reside mainly in Eastern Europe but also represent a noticeable share of the population in the USA and Canada. Slavic populations, particularly Eastern Slavs and some Western Sla
Externí odkaz:
https://doaj.org/article/fc3aacfe338c4fd194a13b9291426c83
Autor:
Anna P. Sokolenko, Luisa V. Sultanova, Ilya A. Stepanov, Alexandr A. Romanko, Aigul R. Venina, Tatiana N. Sokolova, Hedi S. Musayeva, Marina Ya. Tovgereeva, Mareta Kh. Magomedova, Khusein U. Akhmatkhanov, Elisa I. Vagapova, Elkhan A. Suleymanov, Elena V. Vasilyeva, Elvina Kh. Bakaeva, Ilya V. Bizin, Svetlana N. Aleksakhina, Evgeny N. Imyanitov
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 3167-3171 (2023)
Abstract Coding sequences of BRCA1, BRCA2, ATM, TP53, and PALB2 genes were analyzed in 68 consecutive Chechen patients with high‐grade serous ovarian cancer (HGSOC). Pathogenic BRCA1/2 variants were identified in 15 (22%) out of 68 HGSOC cases. Nin
Externí odkaz:
https://doaj.org/article/f722a1ada1774d7089bbe69758a94d6b
Agnostic Administration of Targeted Anticancer Drugs: Looking for a Balance between Hype and Caution
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4094 (2024)
Many tumors have well-defined vulnerabilities, thus potentially allowing highly specific and effective treatment. There is a spectrum of actionable genetic alterations which are shared across various tumor types and, therefore, can be targeted by a g
Externí odkaz:
https://doaj.org/article/31b6221920bf4626ac8a21a7fd1a366c
Publikováno v:
Medical Sciences, Vol 12, Iss 1, p 12 (2024)
Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). Most insta
Externí odkaz:
https://doaj.org/article/4c547d2fb356451aaeef62f8ebd89e70
Autor:
Evgeny N. Imyanitov
Publikováno v:
Современная онкология, Vol 24, Iss 3, Pp 351-354 (2022)
Transcriptome analysis provided a tool to identify expression subtypes of breast cancer (BC). A significant part of BCs are carcinomas that differ in the expression of luminal mammary ductal epithelium markers and estrogen signaling cascade genes (lu
Externí odkaz:
https://doaj.org/article/cda7e58282a545c8b064cdee855b2dfe
Autor:
Christopher Hakkaart, John F. Pearson, Louise Marquart, Joe Dennis, George A. R. Wiggins, Daniel R. Barnes, Bridget A. Robinson, Peter D. Mace, Kristiina Aittomäki, Irene L. Andrulis, Banu K. Arun, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Sami Belhadj, Lieke Berger, Marinus J. Blok, Susanne E. Boonen, Julika Borde, Angela R. Bradbury, Joan Brunet, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Wendy K. Chung, Kathleen B. M. Claes, GEMO Study Collaborators, EMBRACE Collaborators, Marie-Agnès Collonge-Rame, Jackie Cook, Casey Cosgrove, Fergus J. Couch, Mary B. Daly, Sita Dandiker, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Mallika Dhawan, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Alan Donaldson, Jacqueline Eason, Douglas F. Easton, Hans Ehrencrona, Christoph Engel, D. Gareth Evans, Ulrike Faust, Lidia Feliubadaló, Florentia Fostira, Eitan Friedman, Megan Frone, Debra Frost, Judy Garber, Simon A. Gayther, Andrea Gehrig, Paul Gesta, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Eric Hahnen, Christopher R. Hake, Ute Hamann, Thomas V. O. Hansen, Jan Hauke, Julia Hentschel, Natalie Herold, Ellen Honisch, Peter J. Hulick, Evgeny N. Imyanitov, SWE-BRCA Investigators, kConFab Investigators, HEBON Investigators, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Esther M. John, Vijai Joseph, Beth Y. Karlan, Zoe Kemp, Judy Kirk, Irene Konstantopoulou, Marco Koudijs, Ava Kwong, Yael Laitman, Fiona Lalloo, Christine Lasset, Charlotte Lautrup, Conxi Lazaro, Clémentine Legrand, Goska Leslie, Fabienne Lesueur, Phuong L. Mai, Siranoush Manoukian, Véronique Mari, John W. M. Martens, Lesley McGuffog, Noura Mebirouk, Alfons Meindl, Austin Miller, Marco Montagna, Lidia Moserle, Emmanuelle Mouret-Fourme, Hannah Musgrave, Sophie Nambot, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Tu Nguyen-Dumont, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Ana Osorio, Claus-Eric Ott, Sue K. Park, Michael T. Parsons, Inge Sokilde Pedersen, Ana Peixoto, Pedro Perez-Segura, Paolo Peterlongo, Timea Pocza, Paolo Radice, Juliane Ramser, Johanna Rantala, Gustavo C. Rodriguez, Karina Rønlund, Efraim H. Rosenberg, Maria Rossing, Rita K. Schmutzler, Payal D. Shah, Saba Sharif, Priyanka Sharma, Lucy E. Side, Jacques Simard, Christian F. Singer, Katie Snape, Doris Steinemann, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Alison H. Trainer, Vishakha Tripathi, Nadine Tung, Klaartje van Engelen, Elizabeth J. van Rensburg, Ana Vega, Alessandra Viel, Lisa Walker, Jeffrey N. Weitzel, Marike R. Wevers, Georgia Chenevix-Trench, Amanda B. Spurdle, Antonis C. Antoniou, Logan C. Walker
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.
Externí odkaz:
https://doaj.org/article/2008d12983b5437282b0bdff8c8a6bb0
Autor:
Natalia V. Mitiushkina, Alexandr A. Romanko, Elena V. Preobrazhenskaya, Vladislav I. Tiurin, Tatiana I. Ermachenkova, Alexandr S. Martianov, Rimma S. Mulkidjan, Tatiana N. Sokolova, Maksim M. Kholmatov, Ilya V. Bizin, Alexandr O. Ivantsov, Olga S. Yatsuk, Olga A. Zaitseva, Aglaya G. Iyevleva, Ekatherina Sh. Kuligina, Evgeny N. Imyanitov
Publikováno v:
Cancer Medicine, Vol 11, Iss 17, Pp 3226-3237 (2022)
Abstract Background Despite the progress in the development of next‐generation sequencing (NGS), diagnostic PCR assays remain to be utilized in clinical routine due to their simplicity and low cost. Tests for 5′‐/3′‐end mRNA unbalanced expr
Externí odkaz:
https://doaj.org/article/d38a620319e847078e9a0ddad75d9206