The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis.

Autor: Evgeny M Makarov, Tatyana A Shtam, Roman A Kovalev, Rimma A Pantina, Elena Yu Varfolomeeva, Michael V Filatov

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185126 (2017)

P53 protein is more frequently mutated in human tumours compared with the other proteins. While the majority of the p53 mutations, especially within its DNA-binding domain, lead to the loss of the wild-type function, there are accumulating data demon

Externí odkaz: https://doaj.org/article/20e072f7d1cd4fdf93dab958468fdb29

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.

Autor: Helena Hernández, Olga V Makarova, Evgeny M Makarov, Nina Morgner, Yutaka Muto, Daniel Pomeranz Krummel, Carol V Robinson

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7202 (2009)

Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA a

Externí odkaz: https://doaj.org/article/7a58c3b07cf4409ba14d0db75c0593ea

MYC regulates metabolism through vesicular transfer of glycolytic kinases

Autor: Luisa Pieroni, Giuseppe Palmisano, Gianluca Sala, Martina Morini, Evon Poon, Arturo Sala, Louis Chesler, Alessandra Eva, Alexia Tsakaneli, Vincenzo De Laurenzi, Evgeny M. Makarov, Martin R. Larsen, Giuliana Cangemi, Sandra Bibbò, Emily Capone, Olesya Chayka, Victor Corasolla Carregari

Publikováno v: Tsakaneli, A, Carregari, V C, Morini, M, Eva, A, Cangemi, G, Chayka, O, Makarov, E, Bibbò, S, Capone, E, Sala, G, De Laurenzi, V, Poon, E, Chesler, L, Pieroni, L, Larsen, M R, Palmisano, G & Sala, A 2021, ' MYC regulates metabolism through vesicular transfer of glycolytic kinases ', Open Biology, vol. 11, no. 12, 210276 . https://doi.org/10.1098/rsob.210276
Open Biology
Open Biology, Vol 11, Iss 12 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5713034. Copyright © 2021 The Authors. Amplification of the proto-oncogene MYCN is a key molecular aberration in high-risk neuroblastoma and predictive of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9b97ab242ebbd2923beab216db9653
https://findresearcher.sdu.dk:8443/ws/files/197558028/rsob.210276.pdf

Exosomes Transfer p53 between Cells and Can Suppress Growth and Proliferation of p53-Negative Cells

Autor: Evgeny M. Makarov, E. Yu. Varfolomeeva, R. A. Kovalev, Michael V. Filatov, R. A. Pantina, Vladimir Burdakov

Publikováno v: Cell and Tissue Biology. 12:20-26

Exosomes are nanosized vesicles that are secreted by many types of cells. We have found that exosomes secreted by HEK293 and HT-1080 can suppress growth and proliferation of p53-deficient cells. Upon overexpression of exogenous p53-GFP in HEK293 cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6694a274384975ecb999e2deaaf32289
https://doi.org/10.1134/s1990519x18010030

Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity

Autor: Beatrice Nal-Rogier, Valarmathy Murugaiah, Uday Kishore, Hani A. Bashir, Evgeny M. Makarov, Suhair M. Abozaid, Ahmed A. Al-Qahtani, Ansar A. Pathan, Mohammed N. Al-Ahdal

Publikováno v: Immunobiology. 224(3)

Hydrophilic lung surfactant proteins have emerged as key immunomodulators aimed at recognition and clearance of pulmonary pathogens. Surfactant protein A (SP-A) is a surfactant-associated innate immune pattern recognition molecule, which is known to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cc21c61b950d000d650056be5634c8
https://pubmed.ncbi.nlm.nih.gov/30954271