Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Evgeny E. Nikolsky"'
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Neuromuscular junctions (NMJs) are directly involved into such indispensable to life processes as respiration and locomotion. However, motor nerve forms only one synaptic contact at each muscle fiber. This unique configuration requires specific prope
Externí odkaz:
https://doaj.org/article/eb5a270caead4cf1901e5c8a3f6da583
Autor:
Rashid Giniatullin, Irina Shelukhina, Nikita Mikhailov, Polina Abushik, Leniz Nurullin, Evgeny E. Nikolsky
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
BackgroundParasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches. However, neurochemical mechanisms of ch
Externí odkaz:
https://doaj.org/article/85a5180b253d44e99e2ff0411694ef95
Autor:
D. V. Samigullin, N. V. Zhilyakov, A. I. Malomouzh, Ellya Bukharaeva, Evgeny E. Nikolsky, E. F. Khaziev, A. R. Latfullin
Publikováno v:
Neuroscience and Behavioral Physiology. 49:1092-1095
Previous studies of neuromuscular synapses in mammals have detected metabotropic cholinoreceptors (mChR) and GABA receptors. Activation of both types of receptor leads to changes in the intensity of calcium-dependent quantum release of acetylcholine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17a9d3cc13dc578d75a58f25b7d9f37
https://doi.org/10.1007/s11055-019-00844-7
https://doi.org/10.1007/s11055-019-00844-7
Publikováno v:
Amino Acids. 51:1093-1102
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. Since the 1970s, many studies have focused on the role of GABA in the mammalian peripheral nervous system, and particularly in the choline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b462062f07fe091f660aeb5ae674bf7
https://doi.org/10.1007/s00726-019-02754-x
https://doi.org/10.1007/s00726-019-02754-x
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:327-332
In contrast to frog neuromuscular synapses, where noradrenaline (norepinephrine) and its analogues caused synchronization of the acetylcholine release process, in mouse diaphragm endplates noradrenaline increased the degree of asynchrony of neurosecr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e548e11b40aef18cdfbe63cf414dba
https://doi.org/10.1134/s1990747818070012
https://doi.org/10.1134/s1990747818070012
Autor:
Evgeny E. Nikolsky, A. I. Malomouzh
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 12:209-222
Cholinergic synaptic contact between motor neuron and skeletal muscle fiber is perhaps one of the core objects for investigations of molecular mechanisms underlying the communication between neurons and innervated cells. In the studies conducted on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce02d0ed2b04f47371e2386b0b5dca88
https://doi.org/10.1134/s1990747818030078
https://doi.org/10.1134/s1990747818030078
Autor:
A N Tsentsevitsky, Dmitry V. Samigullin, E. F. Khaziev, Evgeny E. Nikolsky, Ellya A. Bukharaeva
Publikováno v:
Acta Naturae. 10:93-96
At neuromuscular junctions, ATP inhibits both the evoked and spontaneous acetylcholine release and inward calcium current operating via presynaptic P2Y receptors. It was shown in the experiments with the frog neuromuscular synapse using specific calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89001e17f7e635000004a069d41273c2
https://doi.org/10.32607/20758251-2018-10-2-93-96
https://doi.org/10.32607/20758251-2018-10-2-93-96
Autor:
Oksana A. Lenina, Alexandra D. Kharlamova, Marina E. Sitdykova, Ayrat R. Nurtdinov, Victor I. Ilyin, Irina V. Zueva, Evgeny E. Nikolsky, Konstantin A. Petrov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Non-selective inhibitors of cholinesterases (ChEs) are clinically used for treatment of myasthenia gravis (MG). While being generally safe, they cause numerous adverse effects including induction of hyperactivity of urinary bladder and intestines aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5537a7fe5662f7c1038dc0ff99af69e2
http://link.springer.com/article/10.1038/s41598-017-18307-9
http://link.springer.com/article/10.1038/s41598-017-18307-9
Autor:
Patrick Masson, Il'dar Kh. Rizvanov, Svetlana S. Lukashenko, Eliana B. Souto, Vasily M. Babaev, Konstantin A. Petrov, Tatiana N. Pashirova, Lucia Ya. Zakharova, Irina V. Zueva, Evgeny E. Nikolsky, Oleg G. Sinyashin
Publikováno v:
ACS Applied Materials & Interfaces. 9:16922-16932
Solid lipid nanoparticles (SLNs) are among the most promising nanocarriers to target the blood–brain barrier (BBB) for drug delivery to the central nervous system (CNS). Encapsulation of the acetylcholinesterase reactivator, pralidoxime chloride (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a85aa51f08beddcb2bea3338ad1a62e
https://doi.org/10.1021/acsami.7b04163
https://doi.org/10.1021/acsami.7b04163
Publikováno v:
Acta Naturae. 10:100-102
Impaired function or insufficient expression of glutamate N-methyl-D-aspartate (NMDA) receptors underlies a number of brain pathologies; these receptors are, therefore, regarded as a pharmacological target for many neuroactive drugs. It was shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f906ee7967b229dec41d0a2947deace
https://doi.org/10.32607/20758251-2018-10-3-100-102
https://doi.org/10.32607/20758251-2018-10-3-100-102