Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Evgeny A Zemskov"'
Autor:
Rudolf eLucas, Istvan eCzikora, Supriya eSridhar, Evgeny A Zemskov, Aluya eOseghale, Sebastian eCirco, Stephen D. Cederbaum, Trinad eChakraborty, David eFulton, Robert W. Caldwell, Maritza J. Romero
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
The integrity of epithelial and endothelial barriers in the lower airspaces of the lungs has to be tightly regulated, in order to prevent leakage and to assure efficient gas exchange between the alveoli and capillaries. Both G- and G+ bacterial toxin
Externí odkaz:
https://doaj.org/article/5121938012d346488ab5080c08c6e684
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19414 (2011)
Although endosomal compartments have been suggested to play a role in unconventional protein secretion, there is scarce experimental evidence for such involvement. Here we report that recycling endosomes are essential for externalization of cytoplasm
Externí odkaz:
https://doaj.org/article/ad5212c6594344929111761f4cee4378
Autor:
Lakshmi N. R. Thota, Joaquin E. Lopez Rosales, Ivan Placencia, Evgeny A. Zemskov, Paola Tonino, Ashley N. Michael, Stephen M. Black, Andreia Z. Chignalia
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14568 (2023)
The endothelial glycocalyx is a dynamic signaling surface layer that is involved in the maintenance of cellular homeostasis. The glycocalyx has a very diverse composition, with glycoproteins, proteoglycans, and glycosaminoglycans interacting with eac
Externí odkaz:
https://doaj.org/article/60966e6bfe644820b25c645414468c01
Autor:
Alejandro E. Garcia-Flores, Christine M. Gross, Evgeny A. Zemskov, Qing Lu, Kim Tieu, Ting Wang, Stephen M. Black
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Mechanical strain contributes to ventilator-induced lung injury (VILI) through multi-factorial and complex mechanisms that remain unresolved. Prevailing evidence suggests that the loss of pulmonary endothelial tight junctions (TJs) plays a critical r
Externí odkaz:
https://doaj.org/article/fd07dd85eaf34047a5a3314f2d31e722
Autor:
Evgeny A. Zemskov, Christine M. Gross, Saurabh Aggarwal, Marina A. Zemskova, Xiaomin Wu, Chenxin Gu, Ting Wang, Haiyang Tang, Stephen M. Black
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression leads to the disruption of the pulmonary endothelial barrier. Previous studies have suggested that the action of NF-κB as a transcriptional repressor also requir
Externí odkaz:
https://doaj.org/article/872767de9a5d4a08b5affe0f28d47853
Autor:
Hui Wang, Xutong Sun, Qing Lu, Evgeny A. Zemskov, Manivannan Yegambaram, Xiaomin Wu, Ting Wang, Haiyang Tang, Stephen M. Black
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101878- (2021)
Acute lung injury (ALI) is a devastating clinical syndrome with no effective therapies. Inflammasome activation has been reported to play a critical role in the initiation and progression of ALI. The molecular mechanisms involved in regulating the ac
Externí odkaz:
https://doaj.org/article/a51b4ad97d1e40a384a80d88f1dcf05f
Autor:
Qing Lu, Evgeny A. Zemskov, Xutong Sun, Hui Wang, Manivannan Yegambaram, Xiaomin Wu, Alejandro Garcia-Flores, Shanshan Song, Haiyang Tang, Archana Kangath, Gabriela Zubiate Cabanillas, Jason X.-J. Yuan, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101785- (2021)
Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical
Externí odkaz:
https://doaj.org/article/70e418a19b7e4e008e894e2765a02395
Autor:
Qing Lu, Xutong Sun, Manivannan Yegambaram, Wojciech Ornatowski, Xiaomin Wu, Hui Wang, Alejandro Garcia-Flores, Victoria Da Silva, Evgeny A. Zemskov, Haiyang Tang, Jeffrey R. Fineman, Kim Tieu, Ting Wang, Stephen M. Black
Publikováno v:
J Biol Chem
Mitochondrial fission and a Warburg phenotype of increased cellular glycolysis are involved in the pathogenesis of pulmonary hypertension (PH). The purpose of this study was to determine whether increases in mitochondrial fission are involved in a gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1991f87f36d22abe31858d7e6b326a
https://europepmc.org/articles/PMC10060112/
https://europepmc.org/articles/PMC10060112/
Publikováno v:
Physical Review E. 105
We describe analytically, and simulate numerically, traveling waves with oscillatory tails in a bistable, piecewise-linear reaction-diffusion-advection system of the FitzHugh-Nagumo type with linear cross-diffusion and cross-advection terms of opposi
Autor:
Hui Wang, Haiyang Tang, Stephen M. Black, Christine Gross, Ting Wang, Mannivannan Yegambaram, Qing Lu, Saurabh Aggarwal, Evgeny A. Zemskov, Xiaomin Wu
Publikováno v:
The Journal of Biological Chemistry
Phosphodiesterase 3A (PDE3A) selectively cleaves the phosphodiester bond of cAMP and is inhibited by cGMP, making it an important regulator of cAMP-cGMP signaling crosstalk in the pulmonary vasculature. In addition, the nitric oxide-cGMP axis is know