The calcineurin–NFATc pathway modulates the lipid mediators in BAL fluid extracellular vesicles, thereby regulating microvascular endothelial cell barrier function

Autor: Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W. Christman

Publikováno v: Frontiers in Physiology, Vol 15 (2024)

Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmona

Externí odkaz: https://doaj.org/article/e4c82b57f47e4bf2a0bcb4bf10e5e08e

Particulate matter causes skin barrier dysfunction

Autor: Byung Eui Kim, Jihyun Kim, Elena Goleva, Evgeny Berdyshev, Jinyoung Lee, Kathryn A. Vang, Un Ha Lee, SongYi Han, Susan Leung, Clifton F. Hall, Na-Rae Kim, Irina Bronova, Eu Jin Lee, Hye-Ran Yang, Donald Y.M. Leung, Kangmo Ahn

Publikováno v: JCI Insight, Vol 6, Iss 5 (2021)

The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In this study, the effects of PM2.5 on filaggrin (FLG) and skin barrier function were investigated in vitro and

Externí odkaz: https://doaj.org/article/4d6342e3fcc34ccd84edee348430aa91

Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.

Autor: Lavanya Visvabharathy, Samantha Genardi, Liang Cao, Ying He, Francis Alonzo, Evgeny Berdyshev, Chyung-Ru Wang

Publikováno v: PLoS Pathogens, Vol 16, Iss 4, p e1008443 (2020)

Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have la

Externí odkaz: https://doaj.org/article/b57ecb31b2ca48d48fc36cf068858a2f

Dupilumab significantly improves skin barrier function in patients with moderate‐to‐severe atopic dermatitis

Autor: Evgeny Berdyshev, Elena Goleva, Robert Bissonnette, Irina Bronova, Anna Sofia Bronoff, Brittany N. Richers, Shannon Garcia, Marco Ramirez‐Gama, Patricia Taylor, Amy Praestgaard, Inoncent Agueusop, Pauline Jurvilliers, Mark Boguniewicz, Noah A. Levit, Ana B. Rossi, Annie Zhang, Donald Y. M. Leung

Publikováno v: Allergy. 77:3388-3397

Atopic dermatitis (AD) is characterized by abnormal skin lipids that are largely driven by hyperactivated type 2 immune responses. The antibody to the α-subunit of interleukin (IL)-4 receptor, dupilumab, was recently approved to treat AD and demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad3f6ab7970deffecaaffa040f72323
https://doi.org/10.1111/all.15432

Targeting Skin Barrier Function in Atopic Dermatitis

Autor: Ellen H. van den Bogaard, Peter M. Elias, Elena Goleva, Evgeny Berdyshev, Jos P.H. Smits, Simon G. Danby, Michael J. Cork, Donald Y.M. Leung

Publikováno v: Journal of Allergy and Clinical Immunology. In Practice, 11, 5, pp. 1335-1346
Journal of Allergy and Clinical Immunology. In Practice, 11, 1335-1346

Item does not contain fulltext Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of skin barrier dysfunction is complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648f2445b96a63c0ba072d01fc5e361
https://repository.ubn.ru.nl/handle/2066/292717