Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Evgeniya I. Fedotova"'
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 282 (2024)
The mitochondrial network (MN) is a dynamic structure undergoing constant remodeling in the cell. It is assumed that perturbations to the MN may be associated with various pathologies, including Parkinson’s disease (PD). Using automatic image analy
Externí odkaz:
https://doaj.org/article/0baec71249b241b6a7171ab65427b0aa
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2832 (2022)
Parkinson’s disease (PD) is a ubiquitous neurodegenerative disorder for which no effective treatment strategies are available. Existing pharmacotherapy is aimed only at correcting symptoms and slowing the progression of the disease, mainly by reple
Externí odkaz:
https://doaj.org/article/b3291c341cae4737bd556e657e7f8e8f
Autor:
Egor A. Turovsky, Maria V. Turovskaya, Evgeniya I. Fedotova, Alexey A. Babaev, Victor S. Tarabykin, Elena G. Varlamova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5968 (2021)
Transcription factors Satb1 and Satb2 are involved in the processes of cortex development and maturation of neurons. Alterations in the expression of their target genes can lead to neurodegenerative processes. Molecular and cellular mechanisms of reg
Externí odkaz:
https://doaj.org/article/988290a7aa534713a3a0dbf405ac9f23
Autor:
Alexey V. Berezhnov, Evgeniya I. Fedotova, Miroslav N. Nenov, Vitaly A. Kasymov, Oleg Yu. Pimenov, Vladimir V. Dynnik
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7461 (2020)
Long-chain acylcarnitines (LCAC) are implicated in ischemia-reperfusion (I/R)-induced myocardial injury and mitochondrial dysfunction. Yet, molecular mechanisms underlying involvement of LCAC in cardiac injury are not sufficiently studied. It is know
Externí odkaz:
https://doaj.org/article/41a10dab52a247f3a062f5cdafc38877
Publikováno v:
Biomedicines; Volume 10; Issue 11; Pages: 2832
Parkinson’s disease (PD) is a ubiquitous neurodegenerative disorder for which no effective treatment strategies are available. Existing pharmacotherapy is aimed only at correcting symptoms and slowing the progression of the disease, mainly by reple
Autor:
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Y. Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Publikováno v:
Choi, M L, Chappard, A, Singh, B P, Maclachlan, C, Rodrigues, M, Fedotova, E I, Berezhnov, A V, De, S, Peddie, C J, Athauda, D, Virdi, G S, Zhang, W, Evans, J R, Wernick, A I, Zanjani, Z S, Angelova, P R, Esteras, N, Vinokurov, A Y, Morris, K, Jeacock, K, Tosatto, L, Little, D, Gissen, P, Clarke, D J, Kunath, T, Collinson, L, Klenerman, D, Abramov, A Y, Horrocks, M H & Gandhi, S 2022, ' Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity ', Nature Neuroscience, vol. 25, no. 9, pp. 1134-1148 . https://doi.org/10.1038/s41593-022-01140-3
Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the intracellular conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3d3048d03d51924ef12304959194c2
Autor:
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Y. Vinokurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Publikováno v:
Nature Neuroscience. 25:1582-1582
Publikováno v:
Molecular neurobiology. 59(1)
Intracellular quality control regulated by autophagy process is important for maintenance of cellular homeostasis. Deregulation of autophagy and more specifically mitophagy leads to accumulation of the misfolded proteins and damaged mitochondria that