Relationship between the Oligomeric Status of HIV-1 Integrase on DNA and Enzymatic Activity

Autor: Marina Gottikh, Olivier Delelis, Elvire Guiot, Françoise Simon, Patrick Tauc, Jean-Claude Brochon, Jean-François Mouscadet, Evgenii M. Zubin, Eric Deprez, Kevin Carayon

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (32), pp.22707-19. ⟨10.1074/jbc.M602198200⟩

The 3'-processing of the extremities of viral DNA is the first of two reactions catalyzed by HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete integration, but it remains unclear which oligomer is responsible for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5a147e02e9d0b142bb2c0c45eae915
https://doi.org/10.1074/jbc.m602198200

Modern methods for the synthesis of peptide–oligonucleotide conjugates

Autor: T. S. Oretskaya, Evgenii M. Zubin, Elena A. Romanova

Publikováno v: Russian Chemical Reviews. 71:239-264

The published data on the methods of chemical solution and solid-phase synthesis of peptide–oligonucleotide conjugates are reviewed. The known methods are systematised and their advantages and disadvantages are considered. The approaches to the sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9580fc17216ade8c53d2e7d0da6293b6
https://doi.org/10.1070/rc2002v071n03abeh000707

Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA

Autor: Evgenii M. Zubin, Sophie Barbe, Jean-François Mouscadet, Timofei S. Zatsepin, Eric Deprez, Maksim Smolov, Marina Gottikh, Marc Le Bret, Julia Agapkina

Publikováno v: Journal of Biological Chemistry 17 (281), 11530-11540. (2006)
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (17), pp.11530-40. ⟨10.1074/jbc.M512271200⟩

The specific activity of the human immunodeficiency virus, type 1 (HIV-1), integrase on the viral long terminal repeat requires the binding of the enzyme to certain sequences located in the U3 and U5 regions at the ends of viral DNA, but the determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadafa5000c6c5a551bef7b3bb1e95f7
http://prodinra.inra.fr/record/325172