Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Evgenia V. Dueva"'
1
Drug discovery today: no molecules required
Autor: Evgenia V. Dueva, Alexander Y Panchin, Nikita N Khromov-Borisov
Publikováno v: BMJ Evidence-Based Medicine. 24:48-52
During the last fifteen years, numerous peer-reviewed journals published articles about the incredible properties of so-called release-active “drugs” (RADs).1–24 It is claimed that these “drugs” are effective against tick-borne encephalitis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489cf7f14e721ddbf434db11959c4641
https://doi.org/10.1136/bmjebm-2018-111121
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2
Spectrum of antiviral activity of 4-aminopyrimidine
Autor: Evgenia V, Dueva, Ksenia K, Tuchynskaya, Liubov I, Kozlovskaya, Dmitry I, Osolodkin, Kseniya N, Sedenkova, Elena B, Averina, Vladimir A, Palyulin, Galina G, Karganova
Publikováno v: Antiviral Chemistry & Chemotherapy
Tick-borne encephalitis is an important human arbovirus neuroinfection spread across the Northern Eurasia. Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n-octyl-β-d-glucoside (β-OG) pocket, wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90bf3e50dd36fc1af6aca3d8f163925d
https://pubmed.ncbi.nlm.nih.gov/32811155
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3
A facile metal-free approach to N,N′-bis(1-oxidopyrimidin-4-yl)diamines with promising biological activity
Autor: Tamara S. Kuznetsova, Alexey A. Orlov, Elena B. Averina, Evgeny V. Khvatov, Kseniya N. Sedenkova, Anna A. Nazarova, Dmitry I. Osolodkin, Vladimir A. Palyulin, Yuri K. Grishin, Evgenia V. Dueva
Publikováno v: Mendeleev Communications. 28:592-594
Novel N-(1-oxidopyrimidin-4-yl)- and N,N′-bis(1-oxidopyrimidin-4-yl)diamines were prepared from 4-fluoropyrimidine N-oxides and diamines basing on SNAr reaction. One compound from this series possessed antiviral activity against tick-borne encephal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::319263154984516f09383a091aea6193
https://doi.org/10.1016/j.mencom.2018.11.009
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4
Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models
Autor: Fuqiang Ban, Evgenia V. Dueva, Takeshi Yamazaki, Nada Lallous, Nader Al Nakouzi, Martin E. Gleave, Amina Zoubeidi, Susan C. Moore, Nham T. Nguyen, Fan Zhang, Neetu Saxena, Sophie M. Stief, Lucia Nappi, Dulguun Battsogt, Eliana Beraldi, Marisa Thi, Barbara Lelj-Garolla, Artem Cherkasov, Adeleke H Aguda, Gary D. Brayer, Ladan Fazli
Publikováno v: J Clin Invest
HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structure-gui
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e7e5717c173cfc68e7cf7ebb1f87e5
https://pubmed.ncbi.nlm.nih.gov/31845908
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5
Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane
Autor: Dmitry I. Osolodkin, Liubov I. Kozlovskaya, N. A. Zefirov, Dmitry A. Vasilenko, Yuri K. Grishin, Galina G. Karganova, Elena B. Averina, Gennady M. Butov, Olga N. Zefirova, Evgenia V. Dueva, Tamara S. Kuznetsova, Vladimir A. Palyulin
Publikováno v: Bioorganic chemistry. 87
Infections caused by flaviviruses pose a huge threat for public health all over the world. The search for therapeutically relevant compounds targeting tick-borne flaviviruses requires the exploration of novel chemotypes. In the present work a large s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2990054b4f1674f2de5d3c7818a38fe
https://pubmed.ncbi.nlm.nih.gov/30947098
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6
Spectrum of antiviral activity of 4-aminopyrimidine N-oxides against a broad panel of tick-borne encephalitis virus strains
Autor: Evgenia V. Dueva, Ksenia K. Tuchynskaya, Galina G. Karganova, Dmitry I. Osolodkin, Liubov I. Kozlovskaya, Elena B. Averina, Kseniya N. Sedenkova, Vladimir A. Palyulin
Publikováno v: Antiviral Chemistry & Chemotherapy, Vol 28 (2020)
Tick-borne encephalitis is an important human arbovirus neuroinfection spread across the Northern Eurasia. Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n-octyl-β-d-glucoside (β-OG) pocket, wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f07c672be8f20d4344b206640849ef
https://doi.org/10.1177/2040206620943462
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7
Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor
Autor: Anastasia Kalyta, Paul S. Rennie, Eric Leblanc, Evgenia V. Dueva, Kriti Singh, Artem Cherkasov
Publikováno v: Molecules, Vol 23, Iss 11, p 2967 (2018)
Molecules
Volume 23
Issue 11
Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged implicating TLX in prostate and breast cancer.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc73d92d3fbeeff383fb49ee9bee884
https://www.mdpi.com/1420-3049/23/11/2967
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8
Synthesis and assessment of 4-aminotetrahydroquinazoline derivatives as tick-borne encephalitis virus reproduction inhibitors
Autor: Liubov I. Kozlovskaya, Boris S. Orlinson, Gennady M. Butov, Ivan A. Novakov, Dmitry I. Osolodkin, Evgenia V. Dueva, Yuri K. Grishin, E. N. Savelyev, Vladimir A. Palyulin, Tamara S. Kuznetsova, Elena B. Averina, Galina G. Karganova, Kseniya N. Sedenkova, Nikolay S. Zefirov
Publikováno v: Organic & Biomolecular Chemistry. 13:3406-3415
Tick-borne encephalitis virus (TBEV) belonging to Flavivirus genus causes severe infection in humans. The search for therapeutically relevant compounds targeting TBEV requires the exploration of novel chemotypes. A versatile synthesis of previously u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1763bc469b98aa48d6e46bd6d58206a2
https://doi.org/10.1039/c4ob02649g
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9
Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations
Autor: Vladimir M. Pentkovski, Dmitry I. Osolodkin, Nikolay S. Zefirov, Liubov I. Kozlovskaya, Evgenia V. Dueva, Vladimir A. Palyulin
Publikováno v: Molecular informatics. 33(10)
Flaviviral diseases, including dengue fever, West Nile fever, yellow fever, tick-borne encephalitis, Omsk haemorrhagic fever, and Powassan encephalitis, threaten human health all over the world. Lack of effective antivirals targeting replication cycl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04b146dd3db714fc0dae7815225bf21
https://pubmed.ncbi.nlm.nih.gov/27485304
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