Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Evgenia Salta"'
Autor:
Amber Penning, Sarah Snoeck, Oxana Garritsen, Giorgia Tosoni, Amber Hof, Fleur de Boer, Joëlle van Hasenbroek, Lin Zhang, Nicky Thrupp, Katleen Craessaerts, Mark Fiers, Evgenia Salta
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The generation of new neurons at the hippocampal neurogenic niche, known as adult hippocampal neurogenesis (AHN), and its impairment, have been implicated in Alzheimer’s disease (AD). MicroRNA-132 (miR-132), the most consistently downregul
Externí odkaz:
https://doaj.org/article/594b1963cda84dbe8489550870eb8dbb
Autor:
Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo Mancuso, Mark Fiers, Andrew J.M. Howden, Bart De Strooper, Evgenia Salta
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106829- (2023)
Summary: microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer’s disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathologie
Externí odkaz:
https://doaj.org/article/fb4068bec1c2405a988aa5fa7009aa7c
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from thei
Externí odkaz:
https://doaj.org/article/e43a11d9d7444dbc9f5e8a4b95efafba
Autor:
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fiers
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-18 (2020)
Abstract Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathw
Externí odkaz:
https://doaj.org/article/9a1d1c2a487742f998b71f756bbae582
Autor:
Amber Penning, Giorgia Tosoni, Oihane Abiega, Pascal Bielefeld, Caterina Gasperini, Davide De Pietri Tonelli, Carlos P. Fitzsimons, Evgenia Salta
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
The adult neurogenic niches are complex multicellular systems, receiving regulatory input from a multitude of intracellular, juxtacrine, and paracrine signals and biological pathways. Within the niches, adult neural stem cells (aNSCs) generate astroc
Externí odkaz:
https://doaj.org/article/66b59016ce8946bf8754d3b672b30bef
Autor:
Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, David Blum, Luc Buée, Mark Fiers, Bart De Strooper
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic memory loss. MicroRNA (miRNA) deregulation is well established in AD bra
Externí odkaz:
https://doaj.org/article/5b299d246bfe4e12b8032f1dd8510539
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1005-1018 (2016)
Abstract microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐promoting functions in the nervous system and has been found consistently downregulated in Alzheimer's disease (AD). Whether and how miR‐132 deficiency
Externí odkaz:
https://doaj.org/article/f521c62afe5f42edbe64337d8bb51b38
Autor:
Evgenia Salta, Eirini Kanata, Christos A. Ouzounis, Sabine Gilch, Hermann Schätzl, Theodoros Sklaviadis
Publikováno v:
Viruses, Vol 6, Iss 11, Pp 4398-4421 (2014)
The key event in prion pathogenesis is the structural conversion of the normal cellular protein, PrPC, into an aberrant and partially proteinase K resistant isoform, PrPSc. Since the minimum requirement for a prion disease phenotype is the expression
Externí odkaz:
https://doaj.org/article/6573caba9c344f43aafc97283d84ff4c
Autor:
Pierre Lau, Koen Bossers, Rekin's Janky, Evgenia Salta, Carlo Sala Frigerio, Shahar Barbash, Roy Rothman, Annerieke S. R. Sierksma, Amantha Thathiah, David Greenberg, Aikaterini S. Papadopoulou, Tilmann Achsel, Torik Ayoubi, Hermona Soreq, Joost Verhaagen, Dick F. Swaab, Stein Aerts, Bart De Strooper
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 10, Pp 1613-1634 (2013)
Abstract An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs. Profiling of miRNAs in the prefronta
Externí odkaz:
https://doaj.org/article/87c601fc2df24e67877e1f80927ffdc3
Autor:
Evgenia Salta, Cynthia Panagiotidis, Konstantinos Teliousis, Spyros Petrakis, Eleftherios Eleftheriadis, Fotis Arapoglou, Nikolaos Grigoriadis, Anna Nicolaou, Eleni Kaldrymidou, Grigorios Krey, Theodoros Sklaviadis
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6175 (2009)
In transmissible spongiform encephalopathies (TSEs), a group of fatal neurodegenerative disorders affecting many species, the key event in disease pathogenesis is the accumulation of an abnormal conformational isoform (PrP(Sc)) of the host-encoded ce
Externí odkaz:
https://doaj.org/article/cb58a0df31424a588557db46f17f7820