Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Evgenia Megalou"'
Autor:
Ioannis Dafnis, Angeliki Chroni, Christina Mountaki, Vassilis I. Zannis, Evgenia Megalou, Christina Raftopoulou
Publikováno v:
The Biochemical journal. 475(10)
The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-β peptide (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD). Changes in brain cholesterol homeostasis have been suggested to af
Autor:
Gino Heeren, Nektarios Tavernarakis, Kai-Uwe Fröhlich, Birthe Fahrenkrog, Elisabeth Schraml, Beatrix Grubeck-Loebenstein, Lucia Antonacci, Alexandra Schauer, Nadège Minois, Alfredo Criollo, Luiza Deszcz, Heike Fussi, Daniela Weiskopf, Heide Knauer, Frank Sinner, Julia Ring, Tobias Eisenberg, Sabrina Schroeder, Evgenia Megalou, Christoph Magnes, Michael Breitenbach, Regina Hartl, Sabrina Büttner, Christoph Ruckenstuhl, Frank Madeo, Eva Herker, Peter Laun, Didac Carmona-Gutierrez, Guido Kroemer
Publikováno v:
Nature Cell Biology; Vol 11
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose in
Autor:
Nektarios Tavernarakis, George J. Tserevelakis, Barbara Petanidou, Evgenia Megalou, Costas Fotakis, George Filippidis
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84431 (2014)
PLoS ONE
PLoS ONE
Elucidation of the molecular mechanisms regulating lipid storage and metabolism is essential for mitigating excess adiposity and obesity, which has been associated with increased prevalence of severe pathological conditions such as cardiovascular dis
Autor:
Sara Gelino, Nektarios Tavernarakis, Bart P. Braeckman, Ivano Condò, Ilaria Guccini, Roberto Testi, Natascia Ventura, Malene Hansen, Laura Marzocchella, Evgenia Megalou, Natascha Castelein, Florence Malisan, Shane L. Rea, Roberto Bei, Alison M. Kell, Alfonso Schiavi, Alessandro Torgovnick
Publikováno v:
Experimental Gerontology
Europe PubMed Central
Europe PubMed Central
Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638b3584bb3911cbcb436fa8218d97d6
http://hdl.handle.net/2108/79131
http://hdl.handle.net/2108/79131
Autor:
Alfredo Criollo, Shensi Shen, Lorenzo Galluzzi, Nektarios Tavernarakis, Sabrina Schroeder, Carlos López-Otín, Guillermo Mariño, Martin V. Bennetzen, Paule Bénit, Eugenia Morselli, Tobias Eisenberg, Frank Madeo, Pierre Rustin, Sandra Cabrera, Yoshiyuki Horio, Maria Chiara Maiuri, Jens S. Andersen, Guido Kroemer, Oliver Kepp, Shoaib Ahmad Malik, Evgenia Megalou
Publikováno v:
ResearcherID
Autophagy
Mariño, G, Morselli, E, Bennetzen, M V, Eisenberg, T, Megalou, E, Schroeder, S, Cabrera, S, Bénit, P, Rustin, P, Criollo, A, Kepp, O, Galluzzi, L, Shen, S, Malik, S A, Maiuri, M C, Horio, Y, López-Otín, C, Andersen, J S, Tavernarakis, N, Madeo, F & Kroemer, G 2011, ' Longevity-relevant regulation of autophagy at the level of the acetylproteome ', Autophagy, vol. 7, no. 6, pp. 647-9 . https://doi.org/10.4161/auto.7.6.15191
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Autophagy
Mariño, G, Morselli, E, Bennetzen, M V, Eisenberg, T, Megalou, E, Schroeder, S, Cabrera, S, Bénit, P, Rustin, P, Criollo, A, Kepp, O, Galluzzi, L, Shen, S, Malik, S A, Maiuri, M C, Horio, Y, López-Otín, C, Andersen, J S, Tavernarakis, N, Madeo, F & Kroemer, G 2011, ' Longevity-relevant regulation of autophagy at the level of the acetylproteome ', Autophagy, vol. 7, no. 6, pp. 647-9 . https://doi.org/10.4161/auto.7.6.15191
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the di
Autor:
Alfredo Criollo, Shoaib Ahmad Malik, Maria Chiara Maiuri, Lorenzo Galluzzi, Martin V. Bennetzen, Carlos López-Otín, Guillermo Mariño, Paule Bénit, Eugenia Morselli, Nektarios Tavernarakis, Sabrina Schroeder, Shensi Shen, Frank Madeo, Evgenia Megalou, Tobias Eisenberg, Sandra Cabrera, Yoshiyuki Horio, Guido Kroemer, Pierre Rustin, Oliver Kepp, Jens S. Andersen
Publikováno v:
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The Journal of Cell Biology
The Journal of Cell Biology; Vol 192
Morselli, E, Mariño, G, Bennetzen, M V, Eisenberg, T, Megalou, E, Schroeder, S, Cabrera, S, Bénit, P, Rustin, P, Criollo, A, Kepp, O, Galluzzi, L, Shen, S, Malik, S A, Maiuri, M C, Horio, Y, López-Otín, C, Andersen, J S, Tavernarakis, N, Madeo, F & Kroemer, G 2011, ' Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome ', Journal of Cell Biology, vol. 192, no. 4, pp. 615-29 . https://doi.org/10.1083/jcb.201008167
instname
The Journal of Cell Biology
The Journal of Cell Biology; Vol 192
Morselli, E, Mariño, G, Bennetzen, M V, Eisenberg, T, Megalou, E, Schroeder, S, Cabrera, S, Bénit, P, Rustin, P, Criollo, A, Kepp, O, Galluzzi, L, Shen, S, Malik, S A, Maiuri, M C, Horio, Y, López-Otín, C, Andersen, J S, Tavernarakis, N, Madeo, F & Kroemer, G 2011, ' Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome ', Journal of Cell Biology, vol. 192, no. 4, pp. 615-29 . https://doi.org/10.1083/jcb.201008167
The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy.
Autophagy protects organelles, cells, and organisms against several stress condit
Autophagy protects organelles, cells, and organisms against several stress condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2511b9188ca5d7b50f2d266423527c
http://hdl.handle.net/10651/11318
http://hdl.handle.net/10651/11318
Autor:
Alfredo Criollo, Maria Chiara Maiuri, Guido Kroemer, Shoaib Ahmad Malik, Mickaël Michaud, Lorenzo Galluzzi, Angela Pasparaki, Evgenia Megalou, Nektarios Tavernarakis, Maria Markaki, Ilio Vitale, Konstantinos Palikaras, Frank Madeo, Eugenia Morselli
Publikováno v:
Autophagy
ResearcherID
Europe PubMed Central
ResearcherID
Europe PubMed Central
The life span of various model organisms can be extended by caloric restriction as well as by autophagy-inducing pharmacological agents. Life span-prolonging effects have also been observed in yeast cells, nematodes and flies upon the overexpression
Publikováno v:
Europe PubMed Central
Macroautophagy (or autophagy) is a catabolic process responsible for the degradation of long-lived proteins, molecules and organelles. Cellular stressors such as food limitation, space restriction, oxidative stress, temperature shifts, and accumulati
Autor:
Bart P. Braeckman, Alison M. Kell, Ilaria Guccini, Laura Marzocchella, Evgenia Megalou, Sara Gelino, Nektarios Tavernarakis, Alfonso Schiavi, Florence Malisan, Natascha Castelein, Roberto Testi, Ivano Condò, Shane L. Rea, Natascia Ventura, Malene Hansen, Alessandro Torgovnick, Roberto Bei
Publikováno v:
Experimental Gerontology
Autor:
Mickaël Michaud, Evgenia Megalou, Maria Markaki, Alfredo Criollo, Guido Kroemer, Shoaib Ahmad Malik, Eugenia Morselli, Lorenzo Galluzzi, Nektarios Tavernarakis, Frank Madeo, Ilio Vitale, Konstantinos Palikaras, Angela Pasparaki, Maria Chiara Maiuri
Publikováno v:
Europe PubMed Central
Cell Death & Disease
Cell Death & Disease
Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e77210dddd7b9bd573dbe4253977bee
http://europepmc.org/abstract/med/21364612
http://europepmc.org/abstract/med/21364612