Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Evette S. Radisky"'
Autor:
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R. Caulfield, Evette S. Radisky, Niv Papo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled by natural tissue inhibitors of metalloproteinases (TIMPs) that non-selectively inhibit th
Externí odkaz:
https://doaj.org/article/9302df7774f5463d897a9547d6d88c2a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The study of protein-protein interactions (PPIs) and the engineering of protein-based inhibitors often employ two distinct strategies. One approach leverages the power of combinatorial libraries, displaying large ensembles of mutant proteins, for exa
Externí odkaz:
https://doaj.org/article/be8d1e8857ee478aad14844512aafaed
Autor:
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication for
Externí odkaz:
https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of protein
Externí odkaz:
https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
Autor:
Mathew A. Coban, Juliet Morrison, Sushila Maharjan, David Hyram Hernandez Medina, Wanlu Li, Yu Shrike Zhang, William D. Freeman, Evette S. Radisky, Karine G. Le Roch, Carla M. Weisend, Hideki Ebihara, Thomas R. Caulfield
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 787 (2021)
COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus res
Externí odkaz:
https://doaj.org/article/5259dd92bbc94afa8affdae5de62738b
Autor:
Evette S. Radisky
Publikováno v:
IUCrJ, Vol 7, Iss 1, Pp 3-4 (2020)
Externí odkaz:
https://doaj.org/article/95effe5e7cf74f40ad5aac99bdb1478b
Autor:
Christine Mehner, Evette S. Radisky
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Externí odkaz:
https://doaj.org/article/fc34afdd39d4486fb638c84a45b447e6
Autor:
Zsanett Jancsó, Grzegorz Oracz, Aleksandra Anna Kujko, Eliwira Kolodziejczyk, Evette S. Radisky, Agnieszka Magdalena Rygiel, Miklós Sahin-Tóth
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Mutations in the PRSS1 (serine protease 1) gene encoding human cationic trypsinogen cause hereditary pancreatitis or may be associated with sporadic chronic pancreatitis. The mutations exert their pathogenic effect either by increasing intra-pancreat
Externí odkaz:
https://doaj.org/article/df4d6f77034c4e93a3517557130b8ac0
Autor:
Hannu Koistinen, Ruusu‐Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf‐Håkan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti
Publikováno v:
IUBMB Life. 75:493-513
Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many
Autor:
Paula Duch, Natalia Díaz-Valdivia, Rafael Ikemori, Marta Gabasa, Evette S. Radisky, Marselina Arshakyan, Sabrina Gea-Sorlí, Anna Mateu-Bosch, Paloma Bragado, Josep Lluís Carrasco, Hidetoshi Mori, Josep Ramírez, Cristina Teixidó, Noemí Reguart, Cristina Fillat, Derek C. Radisky, Jordi Alcaraz
Publikováno v:
Matrix Biology. 111:207-225
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metalloproteinases. Intriguingl