Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Evette S. Radisky"'
Autor:
Jason Shirian, Alexandra Hockla, Justyna J. Gleba, Matt Coban, Naama Rotenberg, Laura M. Strik, Aylin Alasonyalilar Demirer, Matt L. Pawlush, John A. Copland, Evette S. Radisky, Julia M. Shifman
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1187 (2024)
Matrix metalloproteinases (MMPs) are significant drivers of many diseases, including cancer, and are established targets for drug development. Tissue inhibitors of metalloproteinases (TIMPs) are endogenous MMP inhibitors and are being pursued for the
Externí odkaz:
https://doaj.org/article/b253b19360e542278f32a16290c84c97
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The study of protein-protein interactions (PPIs) and the engineering of protein-based inhibitors often employ two distinct strategies. One approach leverages the power of combinatorial libraries, displaying large ensembles of mutant proteins, for exa
Externí odkaz:
https://doaj.org/article/be8d1e8857ee478aad14844512aafaed
Autor:
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R. Caulfield, Evette S. Radisky, Niv Papo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled by natural tissue inhibitors of metalloproteinases (TIMPs) that non-selectively inhibit th
Externí odkaz:
https://doaj.org/article/9302df7774f5463d897a9547d6d88c2a
Autor:
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication for
Externí odkaz:
https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
Autor:
Shiran Lacham-Hartman, Yulia Shmidov, Evette S Radisky, Ronit Bitton, David B Lukatsky, Niv Papo
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0249616 (2021)
Although myriad protein-protein interactions in nature use polyvalent binding, in which multiple ligands on one entity bind to multiple receptors on another, to date an affinity advantage of polyvalent binding has been demonstrated experimentally onl
Externí odkaz:
https://doaj.org/article/85fd5f0416b848ddb4bd776b3283d717
Autor:
Hannu Koistinen, Ruusu‐Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf‐Håkan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti
Publikováno v:
IUBMB Life. 75:493-513
Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of protein
Externí odkaz:
https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
Autor:
Paula Duch, Natalia Díaz-Valdivia, Rafael Ikemori, Marta Gabasa, Evette S. Radisky, Marselina Arshakyan, Sabrina Gea-Sorlí, Anna Mateu-Bosch, Paloma Bragado, Josep Lluís Carrasco, Hidetoshi Mori, Josep Ramírez, Cristina Teixidó, Noemí Reguart, Cristina Fillat, Derek C. Radisky, Jordi Alcaraz
Publikováno v:
Matrix Biology. 111:207-225
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an important regulator of extracellular matrix turnover that has been traditionally regarded as a potential tumor suppressor owing to its inhibitory effects of matrix metalloproteinases. Intriguingl
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Autor:
Mathew A. Coban, Juliet Morrison, Sushila Maharjan, David Hyram Hernandez Medina, Wanlu Li, Yu Shrike Zhang, William D. Freeman, Evette S. Radisky, Karine G. Le Roch, Carla M. Weisend, Hideki Ebihara, Thomas R. Caulfield
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 787 (2021)
COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus res
Externí odkaz:
https://doaj.org/article/5259dd92bbc94afa8affdae5de62738b