Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Evert Homan"'
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulatio
Externí odkaz:
https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8af88760aa3d4c38b6df8ba59624e3f1
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bc9eb2d0df2cb71d1f9ae89c01980c
https://doi.org/10.1158/0008-5472.22414458
https://doi.org/10.1158/0008-5472.22414458
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
Buffers for MTHFD2 and MTHFD1 DC-domain lysis, purification and inhibition assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b582a3653a74d99a229e83fd3a02ea1e
https://doi.org/10.1158/0008-5472.22414455
https://doi.org/10.1158/0008-5472.22414455
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2, a mitochondrial methyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b1c130815606c4da40d07eee51a98b
https://doi.org/10.1158/0008-5472.c.6508983.v1
https://doi.org/10.1158/0008-5472.c.6508983.v1
Autor:
Thomas Helleday, Pål Stenmark, Ulrika Warpman Berglund, Carsten Berndt, Evert Homan, Jordi Carreras Puigvert, Stella Karsten, Robert Gustafsson, Mohit Narwal, Helge Gad, Ann-Sofie Jemth, Linda Pudelko, Lars Bräutigam
Cancer cells are commonly in a state of redox imbalance that drives their growth and survival. To compensate for oxidative stress induced by the tumor redox environment, cancer cells upregulate specific nononcogenic addiction enzymes, such as MTH1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22df73fc0905aa412d6ad8a9fe08060b
https://doi.org/10.1158/0008-5472.c.6507759
https://doi.org/10.1158/0008-5472.c.6507759
Autor:
Thomas Helleday, Pål Stenmark, Ulrika Warpman Berglund, Carsten Berndt, Evert Homan, Jordi Carreras Puigvert, Stella Karsten, Robert Gustafsson, Mohit Narwal, Helge Gad, Ann-Sofie Jemth, Linda Pudelko, Lars Bräutigam
Table S1: The redox status of the cell correlates with sensitivity to MTH1 inhibition. Table S2: Data collection and refinement statistics. Table S3: Kinetic parameters of zfMTH1. Table S4: Primer sequences. Figure S1: BSO treatment sensitizes U2OS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ea07356ee8e4f686118522dfa0567f
https://doi.org/10.1158/0008-5472.22409340
https://doi.org/10.1158/0008-5472.22409340
Autor:
Olov Wallner, Armando Cázares‐Körner, Emma Rose Scaletti, Geoffrey Masuyer, Tove Bekkhus, Torkild Visnes, Kirill Mamonov, Florian Ortis, Thomas Lundbäck, Maria Volkova, Tobias Koolmeister, Elisée Wiita, Olga Loseva, Monica Pandey, Evert Homan, Carlos Benítez‐Buelga, Jonathan Davies, Martin Scobie, Ulrika Warpman Berglund, Christina Kalderén, Pål Stenmark, Thomas Helleday, Maurice Michel
Publikováno v:
ChemMedChem. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2057798a6f1ce2cc79a2bd7cf5f16fc
https://doi.org/10.1002/cmdc.202200681
https://doi.org/10.1002/cmdc.202200681
Autor:
Alanna C. Green, Petra Marttila, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernardin, Karl S. A. Vallin, Sanjay Borhade, Maeve Long, Elahe Kamali Ghahe, Julio J. Jiménez-Alonso, Ann-Sofie Jemth, Olga Loseva, Oliver Mortusewicz, Marianne Meyers, Elodie Viry, Annika I. Johansson, Ondřej Hodek, Evert Homan, Nadilly Bonagas, Louise Ramos, Lars Sandberg, Morten Frödin, Etienne Moussay, Ana Slipicevic, Elisabeth Letellier, Jérôme Paggetti, Claus Storgaard Sørensen, Thomas Helleday, Martin Henriksson, Johannes Meiser
Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon (1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase-cyclohydrolase 1 and 2 (MTHFD1 and MTHFD2). TH9619 is a potent inhibitor of dehydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef4c9b031ee478e94f3df8742d2401f
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206656
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206656
Autor:
Suzanne Ackloo, Albert A. Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Ulrich A. K. Betz, Jark Böttcher, Peter J. Brown, Menorca Chaturvedi, Alisa Crisp, Danette Daniels, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V. Hartung, Alexander Hillisch, Evert Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R. Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H. Todd, Claudia Tredup, Jennifer Venable, Timothy M. Willson, Cheryl H. Arrowsmith
Publikováno v:
RSC Medicinal Chemistry.
Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging ‘open’ principles to develop a pharmacological tool for every human protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3307d439e596fca276308b7255fe64f6
https://doi.org/10.1039/d2md00441k
https://doi.org/10.1039/d2md00441k