Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Evert Bosdriesz"'
Autor:
Evert Bosdriesz, João M. Fernandes Neto, Anja Sieber, René Bernards, Nils Blüthgen, Lodewyk F.A. Wessels
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104760- (2022)
Summary: Targeted inhibition of aberrant signaling is an important treatment strategy in cancer, but responses are often short-lived. Multi-drug combinations have the potential to mitigate this, but to avoid toxicity such combinations must be selecti
Externí odkaz:
https://doaj.org/article/79751c290deb41b19b7a9a972294987f
Autor:
João M. Fernandes Neto, Ernest Nadal, Evert Bosdriesz, Salo N. Ooft, Lourdes Farre, Chelsea McLean, Sjoerd Klarenbeek, Anouk Jurgens, Hannes Hagen, Liqin Wang, Enriqueta Felip, Alex Martinez-Marti, August Vidal, Emile Voest, Lodewyk F. A. Wessels, Olaf van Tellingen, Alberto Villanueva, René Bernards
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
A drug used at the maximum tolerated dose can exert a strong selective pressure on cancer cells leading to resistance. In this study, the authors demonstrate the efficacy of using low dose of multiple drugs for preventing and treating resistance to E
Externí odkaz:
https://doaj.org/article/fa274e19e6774a2dbd7ad05e9103dbab
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 201-211 (2020)
Intrinsic and acquired resistances are major hurdles preventing the effective use of MEK inhibitors for treatment of colorectal cancer (CRC). Some 35–45% of colorectal cancers are KRAS-mutant and their treatment remains challenging as these cancers
Externí odkaz:
https://doaj.org/article/d4a1feb306704b43bccc6c748991d9bd
Autor:
Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/43f2f351f5f845a58e903c76ecfc62de
Autor:
Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understandin
Externí odkaz:
https://doaj.org/article/98f6a24767ca469eb06b9f4fac8d24c6
Autor:
Emile E. Voest, Olaf van Tellingen, Sjoerd Klarenbeek, Anouk Jurgens, Chelsea M. McLean, Evert Bosdriesz, Ernest Nadal, René Bernards, Enriqueta Felip, August Vidal, Salo N. Ooft, Alex Martinez-Marti, Lourdes Farre, Liqin Wang, Hannes Hagen, João M. Fernandes Neto, Alberto Villanueva, Lodewyk F. A. Wessels
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 11(1):3157. Nature Publishing Group
Nature Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Fernandes Neto, J M, Nadal, E, Bosdriesz, E, Ooft, S N, Farre, L, McLean, C, Klarenbeek, S, Jurgens, A, Hagen, H, Wang, L, Felip, E, Martinez-Marti, A, Vidal, A, Voest, E, Wessels, L F A, van Tellingen, O, Villanueva, A & Bernards, R 2020, ' Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours ', Nature Communications, vol. 11, no. 1, 3157, pp. 3157 . https://doi.org/10.1038/s41467-020-16952-9
Universidad de Barcelona
Nature Communications, 11(1):3157. Nature Publishing Group
Nature Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Fernandes Neto, J M, Nadal, E, Bosdriesz, E, Ooft, S N, Farre, L, McLean, C, Klarenbeek, S, Jurgens, A, Hagen, H, Wang, L, Felip, E, Martinez-Marti, A, Vidal, A, Voest, E, Wessels, L F A, van Tellingen, O, Villanueva, A & Bernards, R 2020, ' Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours ', Nature Communications, vol. 11, no. 1, 3157, pp. 3157 . https://doi.org/10.1038/s41467-020-16952-9
Resistance to targeted cancer drugs is thought to result from selective pressure exerted by a high drug dose. Partial inhibition of multiple components in the same oncogenic signalling pathway may add up to complete pathway inhibition, while decreasi
Publikováno v:
Šuštić, T, Bosdriesz, E, van Wageningen, S, Wessels, L F A & Bernards, R 2020, ' RUNX2/CBFB modulates the response to MEK inhibitors through activation of receptor tyrosine kinases in KRAS-mutant colorectal cancer ', Translational oncology, vol. 13, no. 2, pp. 201-211 . https://doi.org/10.1016/j.tranon.2019.10.006
Translational Oncology
Translational Oncology, Vol 13, Iss 2, Pp 201-211 (2020)
Translational oncology, 13(2), 201-211. Neoplasia Press
Translational Oncology
Translational Oncology, Vol 13, Iss 2, Pp 201-211 (2020)
Translational oncology, 13(2), 201-211. Neoplasia Press
Intrinsic and acquired resistances are major hurdles preventing the effective use of MEK inhibitors for treatment of colorectal cancer (CRC). Some 35-45% of colorectal cancers are KRAS-mutant and their treatment remains challenging as these cancers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0679d558780eac871be4a9aaa26e20
https://hdl.handle.net/1871.1/4d06febd-1a3b-4dde-be94-815455860a37
https://hdl.handle.net/1871.1/4d06febd-1a3b-4dde-be94-815455860a37
Autor:
Zheng Xue, Tonći Šuštić, René Bernards, Oscar M. Rueda, Daniel J. Vis, Alejandra Bruna, Sake van Wageningen, Ankita Sati Batra, Carlos Caldas, Evert Bosdriesz, Lodewyk F. A. Wessels
Publikováno v:
Xue, Z, Vis, D J, Bruna, A, Sustic, T, van Wageningen, S, Batra, A S, Rueda, O M, Bosdriesz, E, Caldas, C, Wessels, L F A & Bernards, R 2018, ' MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models ', Cell Research, vol. 28, no. 7, pp. 719-729 . https://doi.org/10.1038/s41422-018-0044-4
Cell Research
Cell Research, 28(7), 719-729. Nature Publishing Group
Cell Research
Cell Research, 28(7), 719-729. Nature Publishing Group
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition activates JNK-JUN signaling
Autor:
Chelsea M. McLean, Emile E. Voest, Alberto Villanueva, Lodewyk F. A. Wessels, Enriqueta Felip, Lourdes Farre, Sjoerd Klarenbeek, João M. Fernandes Neto, Anouk Jurgens, Alex Martinez-Marti, René Bernards, Liqin Wang, Olaf van Tellingen, Hannes Hagen, Evert Bosdriesz, Salo N. Ooft, Ernest Nadal
Targeted cancer drugs often elicit powerful initial responses, but generally fail to deliver long-term benefit due to the emergence of resistant cells1,2. This is thought to be the consequence of strong selective pressure exerted on the cancer drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2bfc178dbeaa6d139b9b2d73e64d19
Autor:
Mathurin Dorel, Torsten Gross, Anja Sieber, Nils Blüthgen, Evert Bosdriesz, Lodewyk F. A. Wessels, Bertram Klinger, Anirudh Prahallad
Publikováno v:
Bioinformatics, 34(23), 4079-4086. Oxford University Press
Dorel, M, Klinger, B, Gross, T, Sieber, A, Prahallad, A, Bosdriesz, E, Wessels, L F A & Blüthgen, N 2018, ' Modelling signalling networks from perturbation data ', Bioinformatics, vol. 34, no. 23, pp. 4079-4086 . https://doi.org/10.1093/bioinformatics/bty473
Dorel, M, Klinger, B, Gross, T, Sieber, A, Prahallad, A, Bosdriesz, E, Wessels, L F A & Blüthgen, N 2018, ' Modelling signalling networks from perturbation data ', Bioinformatics, vol. 34, no. 23, pp. 4079-4086 . https://doi.org/10.1093/bioinformatics/bty473
Motivation Intracellular signalling is realized by complex signalling networks, which are almost impossible to understand without network models, especially if feedbacks are involved. Modular Response Analysis (MRA) is a convenient modelling method t