Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Everett J. Perkins"'
Autor:
Anne H. Dantzig, Everett J. Perkins, Enaksha R. Wickremsinhe, James J. Starling, Gregory P. Donoho, Robert L. Shepard, Sara Durland–Busbice, Susan E. Pratt
PDF file - 112K, Supplementary Figure 2 - in vivo study body weights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b26de16f0ee5d751321264d9d15621d
https://doi.org/10.1158/1535-7163.22498848
https://doi.org/10.1158/1535-7163.22498848
Autor:
Anne H. Dantzig, Everett J. Perkins, Enaksha R. Wickremsinhe, James J. Starling, Gregory P. Donoho, Robert L. Shepard, Sara Durland–Busbice, Susan E. Pratt
PDF file - 316K, Supplementary Figure 1 - in vivo study body weights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b531576d023873277f8bbc6e15fa91
https://doi.org/10.1158/1535-7163.22498851
https://doi.org/10.1158/1535-7163.22498851
Autor:
Anne H. Dantzig, Everett J. Perkins, Enaksha R. Wickremsinhe, James J. Starling, Gregory P. Donoho, Robert L. Shepard, Sara Durland–Busbice, Susan E. Pratt
PDF file - 72K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b0837c46c6fb9854d5f51893366d9a
https://doi.org/10.1158/1535-7163.22498845.v1
https://doi.org/10.1158/1535-7163.22498845.v1
Autor:
Everett J. Perkins, Palaniappan Kulanthaivel, Boris A. Czeskis, Haitao Hu, Kishore Kumar Katyayan
Publikováno v:
Drug Metabolism and Disposition. 45:399-408
Mass balance and metabolism studies using radiolabeled substances are well recognized as an important part of the drug development process. In this study, we directly assessed the use of fluorine nuclear magnetic resonance (19F NMR) to achieve quanti
Autor:
Gregory P. Donoho, Philip Parker Waid, James A. Cook, Michele C. Smith, David Anthony Barda, Volker Wacheck, Yip Yvonne Yee Mai, Philip W. Iversen, Rose T. Ajamie, Debra A. Young, Mary M. Mader, Douglas J. Zeckner, Manuel Vincente Sanchez-Felix, Everett J. Perkins, Laura J. Bloem
Publikováno v:
Molecular Cancer Therapeutics. 15:2344-2356
The PI3K/AKT/mTOR pathway is among the most frequently altered pathways in cancer cell growth and survival. LY3023414 is a complex fused imidazoquinolinone with high solubility across a wide pH range designed to inhibit class I PI3K isoforms and mTOR
Autor:
Maria M. Posada, Jill Chappell, Wee Teck Ng, Everett J. Perkins, Chris Twelves, P. Kellie Turner
Background and Objectives: Cytochrome P450 2C9 (CYP2C9) is involved in the biotransformation of many commonly used drugs, and significant drug interactions have been reported for CYP2C9 substrates. Previously published physiologically based pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b03fef72fc2d9f7b8b6409ca7fa1371
https://eprints.whiterose.ac.uk/146822/1/Perkins2018_Article_PhysiologicallyBasedPharmacoki.pdf
https://eprints.whiterose.ac.uk/146822/1/Perkins2018_Article_PhysiologicallyBasedPharmacoki.pdf
Autor:
Avijit Ghosh, Rob Chambers, Susanna Tse, Zhengyin Yan, Mark G. Qian, Stacy Ho, Paul Harradine, Li Di, Caroline A. Lee, Everett J. Perkins, Robert Fricke, Sean Eckley, J. Cory Kalvass, Christopher Breen, Punit Marathe, Maciej J. Zamek-Gliszczynski
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
Regulatory agencies have recently issued drug-drug interaction guidelines, which require determination of plasma protein binding (PPB). To err on the conservative side, the agencies recommend that a 0.01 lower limit of fraction unbound (fu) be used f
Autor:
Everett J. Perkins, Nicholas Masterson, Alexandar Barr, Nita J. Patel, Tom G. Kern, Jennifer M. Weller, Jennifer L Hanes, Yu-hua Hui, Enaksha R Wickremsinhe, Kenneth J. Ruterbories
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 19, Iss 4 (2016)
Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles. The purpose of this work was to evaluate and optimize blood micros
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4756-4765
Dogs are one of the most commonly used non-rodent species in toxicology studies and are known to have basal stomach pH ranging from 2 to 7 in the fasted state. Thus absorption and resulting plasma exposure of weakly basic compounds administered as cr