Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models.

Autor: Everett MJ; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Davies DT; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Leiris S; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Sprynski N; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Llanos A; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Castandet JM; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Lozano C; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., LaRock CN; Department of Microbiology and Immunology, Rollins Research Center, 1510 Clifton Rd, Atlanta, Georgia 30322, United States., LaRock DL; Department of Microbiology and Immunology, Rollins Research Center, 1510 Clifton Rd, Atlanta, Georgia 30322, United States., Corsica G; Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy., Docquier JD; Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy.; Centre d'Ingénierie des Protéines - InBioS, University of Liège, Allée du six Août 11, 4000 Liège, Belgium., Pallin TD; Charles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K., Cridland A; Charles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K., Blench T; Charles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K., Zalacain M; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France., Lemonnier M; Antabio SAS, Biostep, 436 rue Pierre et Marie Curie, 31670 Labège, France.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2023 Feb 10; Vol. 9 (2), pp. 270-282. Date of Electronic Publication: 2023 Jan 20.

Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro.

Autor: Ren Y; Henan University of Chinese Medicine, Zhengzhou, 450046, China., Zhu R; Henan University of Chinese Medicine, Zhengzhou, 450046, China.; Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China., You X; Henan University of Chinese Medicine, Zhengzhou, 450046, China.; Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China., Li D; Henan University of Chinese Medicine, Zhengzhou, 450046, China.; Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China., Guo M; Henan University of Chinese Medicine, Zhengzhou, 450046, China., Fei B; Henan University of Chinese Medicine, Zhengzhou, 450046, China., Liu Y; Henan University of Chinese Medicine, Zhengzhou, 450046, China., Yang X; Dongzhimen Hospital of Beijing University of Chinese Medicine, Peking, 100700, China. yximing2005@163.com., Liu X; Henan University of Chinese Medicine, Zhengzhou, 450046, China. 43154727@qq.com.; Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China. 43154727@qq.com., Li Y; Henan University of Chinese Medicine, Zhengzhou, 450046, China. lyw@hactcm.edu.cn.; Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450002, China. lyw@hactcm.edu.cn.; The Key Laboratory of Pathogenic Microbes & Antimicrobial Resistance Surveillance of Zhengzhou, Zhengzhou, 450002, China. lyw@hactcm.edu.cn.; Henan Engineering Research Center for Identification of Pathogenic Microbes, Zhengzhou, 450002, China. lyw@hactcm.edu.cn.; Henan Provincial Key Laboratory of Antibiotics-Resistant Bacterial Infection Prevention & Therapy with Traditional Chinese Medicine, Zhengzhou, 450002, China. lyw@hactcm.edu.cn.

Publikováno v: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2024 Dec; Vol. 108 (1), pp. 57. Date of Electronic Publication: 2024 Jan 05.

RsaL is a self‐regulatory switch that controls alternative biosynthesis of two AHL‐type quorum sensing signals in Pseudomonas aeruginosa PA1201.

Autor: He, Ya‐Wen¹ (AUTHOR) yawenhe@sjtu.edu.cn, Jin, Zi‐Jing¹ (AUTHOR), Cui, Ying¹ (AUTHOR), Song, Kai¹ (AUTHOR), Chen, Bo¹ (AUTHOR), Zhou, Lian² (AUTHOR)

Publikováno v: mLife. Mar2024, Vol. 3 Issue 1, p74-86. 13p.

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