Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

Autor: Hector Hernandez-Vargas, Henri Gruffat, Marie Pierre Cros, Audrey Diederichs, Cécilia Sirand, Romina C. Vargas-Ayala, Antonin Jay, Geoffroy Durand, Florence Le Calvez-Kelm, Zdenko Herceg, Evelyne Manet, Christopher P. Wild, Massimo Tommasino, Rosita Accardi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Abstract Epstein-Barr virus (EBV) was identified as the first human virus to be associated with a human malignancy, Burkitt’s lymphoma (BL), a pediatric cancer endemic in sub-Saharan Africa. The exact mechanism of how EBV contributes to the process

Externí odkaz: https://doaj.org/article/cf771775f0f0480bba14d8ec7e78bb0a

Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.

Autor: Maha Siouda, Cecilia Frecha, Rosita Accardi, Jiping Yue, Cyrille Cuenin, Henri Gruffat, Evelyne Manet, Zdenko Herceg, Bakary S Sylla, Massimo Tommasino

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004125 (2014)

The DOK1 tumor suppressor gene encodes an adapter protein that acts as a negative regulator of several signaling pathways. We have previously reported that DOK1 expression is up-regulated upon cellular stress, via the transcription factor E2F1, and d

Externí odkaz: https://doaj.org/article/e6e18cb857244a5ea9da090b3c3287f5

Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.

Autor: Rosita Accardi, Ikbal Fathallah, Henri Gruffat, Giuseppe Mariggiò, Florence Le Calvez-Kelm, Catherine Voegele, Birke Bartosch, Hector Hernandez-Vargas, James McKay, Bakary S Sylla, Evelyne Manet, Massimo Tommasino

Publikováno v: PLoS Pathogens, Vol 9, Iss 3, p e1003186 (2013)

Many studies have proved that oncogenic viruses develop redundant mechanisms to alter the functions of the tumor suppressor p53. Here we show that Epstein-Barr virus (EBV), via the oncoprotein LMP-1, induces the expression of ΔNp73α, a strong antag

Externí odkaz: https://doaj.org/article/2daa063bc6114b1cb45f39acefab311a

[Epstein-Barr virus: A key player in the development of multiple sclerosis]

Autor: Evelyne, Manet, Henri, Gruffat

Publikováno v: Medecine sciences : M/S. 38(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2cdb4f434a72c1476daa3a47d13a2a9
https://pubmed.ncbi.nlm.nih.gov/35608462

Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein

Autor: Paulina Mrozek-Gorska, Fabrice Mure, Wolfgang Hammerschmidt, Didier Auboeuf, Florian Roisné-Hamelin, Evelyne Manet, Henri Gruffat, Hélène Polvèche

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2021, ⟨10.1093/nar/gkab787⟩
Nucleic Acids Res. 49, 10657–10676 (2021)
Nucleic Acids Research, Oxford University Press, 2021, ⟨10.1093/nar/gkab787⟩

Epstein-Barr virus (EBV) is a human herpesvirus associated with human cancers worldwide. Ex vivo, the virus efficiently infects resting human B lymphocytes and induces their continuous proliferation. This process is accompanied by a global reprogramm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13861802b24376c86ee53b1b1952c3f
https://hal.science/hal-03357852