Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Evelyne Dietrich"'
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Autor:
Simon Giroux, Nigel Ewing, Youssef L. Bennani, Francoise Berlioz-Seux, Rebecca S. Shawgo, Anne-Laure Grillot, Nathalie Chauret, Kevin M. Cottrell, Laval C. Chan, Evelyne Dietrich, Francois Denis, Morris Mark A, John Maxwell, Sanjoy Kumar Das, Lucille L’Heureux, Darius Bilimoria, T. Jagadeeswar Reddy, Subajini Selliah, Caroline Cadilhac, Olivier Nicolas, Jinwang Xu, James A. Henderson, Nagraj Mani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:936-939
The discovery of C2-symmetric bis-thienoimidazoles HCV NS5A inhibitors is herein reported. Two straightforward approaches to access the requisite diyne and biphenyl linker moieties are described. This study revealed the paramount importance of the ar
Publikováno v:
Biochemistry. 52:3405-3414
Glycopeptides whose aminosugars have been modified by attachment of hydrophobic side chains are frequently active against vancomycin-resistant microorganisms. We have compared the conformations of six such fluorinated glycopeptides (with side chains
Autor:
Valerie Ostiguy, Tom J. Houghton, Evelyne Dietrich, Ranga Reddy, Odette Belanger, Yanick Lafontaine, Ibtihal Fadhil, Ingrid Sarmiento, Karine Laquerre, Thomas R. Parr, Francis F. Arhin, Anik Dubois, Gregory Moeck, Dario Lehoux, Adel Rafai Far
Publikováno v:
ChemMedChem. 3:1863-1868
Autor:
Karine Laquerre, Francis F. Arhin, Sandra S. Ferreira, Ingrid Sarmiento, Ibtihal Fadhil, Dario Lehoux, Thomas R. Parr, Ting Kang, Kelly S.E. Tanaka, Evelyne Dietrich, Jing Liu, Hugo Poirier, Tom J. Houghton, Laurence Caron, Daniel Delorme, Adel Rafai Far, Valerie Ostiguy, Gregory Moeck, Frederic Viens
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9217-9229
Osteomyelitis is a difficult to treat bacterial infection of the bone. Delivering antibacterial agents to the bone may overcome the difficulties in treating this illness by effectively concentrating the antibiotic at the site of infection and by limi
Autor:
Stephane Ciblat, Ranga Reddy, Geoffrey A. McKay, Jerry Pelletier, Daniel M. Williams, Adel Rafai Far, Odette Belanger, Francis F. Arhin, Jing Liu, Dilip Dixit, Thomas R. Parr, Yannick Rose, Kelly S.E. Tanaka, Mohammed Dehbi, Evelyne Dietrich, Daniel Delorme, Ramakrishnan Srikumar, Yanick Lafontaine, Dario Lehoux, Philippe Gros, Greg Moeck
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5812-5832
The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput screening program based on this enzyme from Staphylococcus aureus had previously identified a 2-ureidothiophene-3-carboxylate as a low micromolar inhibitor.
Autor:
Jian Wang, Anne-Laure Grillot, Carl Poisson, Simon Giroux, Nigel Ewing, Youssef L. Bennani, Rebecca S. Shawgo, Ronald Grey, Louis Vaillancourt, Nathalie Chauret, Darius Bilimoria, Olivier Nicolas, Lucille L’Heureux, Subajini Selliah, Kevin M. Cottrell, B. Govinda Rao, Constantin Yannopoulos, Guy Falardeau, Monica Bubenik, Laval C. Chan, James A. Henderson, Sanjoy Kumar Das, Francois Denis, T. Jagadeeswar Reddy, Caroline Cadilhac, Morris Mark A, Oswy Z. Pereira, Evelyne Dietrich, Nagraj Mani, John Maxwell, Francoise Berlioz-Seux, Bingcan Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The treatment of HCV with highly efficacious, well-tolerated, interferon-free regimens is a compelling clinical goal. Trials employing combinations of direct-acting antivirals that include NS5A inhibitors have shown significant promise in meeting thi
Autor:
Anne-Laure Grillot, Nigel Ewing, Youssef L. Bennani, Simon Giroux, Nathalie Chauret, Caroline Cadilhac, Kevin M. Cottrell, Olivier Nicolas, T. Jagadeeswar Reddy, Evelyne Dietrich, Lucille L’Heureux, Francois Denis, Oswy Z. Pereira, Rebecca S. Shawgo, Jinwang Xu, Nagraj Mani, Francoise Berlioz-Seux, Jian Wang, Sanjoy Kumar Das, John Maxwell, Bingcan Liu, James A. Henderson, Louis Vaillancourt, Subajini Selliah, Guy Falardeau, Laval C. Chan, Morris Mark A, Carl Poisson, Darius Bilimoria, Monica Bubenik
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
Inhibitors of the HCV NS5A nonstructural protein are showing promising clinical potential in the treatment of hepatitis C when used in combination with other direct-acting antiviral agents. Current NS5A clinical candidates such as daclatasvir, ledipa
Autor:
John Maxwell, Francois Denis, Kevin M. Cottrell, Francoise Berlioz-Seux, Subajini Selliah, Rebecca S. Shawgo, Nigel Ewing, Youssef L. Bennani, Morris Mark A, Anne-Laure Grillot, Laval C. Chan, Simon Giroux, Darius Bilimoria, Nagraj Mani, Caroline Cadilhac, T. Jagadeeswar Reddy, James A. Henderson, Olivier Nicolas, Sanjoy Kumar Das, Nathalie Chauret, Jinwang Xu, Lucille L’Heureux, Evelyne Dietrich
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The discovery of non-symmetric thienoimidazole-containing HCV NS5A inhibitors is described. The inhibitors herein reported display high potencies against both genotype 1a and 1b. In this follow-up manuscript, we discuss the importance of the linker a
Autor:
Thomas R. Parr, Stephane Ciblat, Gregory Moeck, Evelyne Dietrich, Adel Rafai Far, Ingrid Sarmiento, Kelly S.E. Tanaka, Claude Métayer, Francis F. Arhin
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(4)
As therapeutic agents of choice in the treatment of complicated infections, glycopeptide antibiotics are often preferentially used in cases of osteomyelitis, an infection located in bone and notoriously difficult to successfully manage. Yet frequent