Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Evelyne, Chelain"'
Autor:
Khoubaib Ben Haj Salah, Francesco Terzani, Marine Pietri, Chiara Zanato, Evelyne Chelain, Julien Pytkowicz
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100333- (2022)
Statins are essential naturally occurring β-hydroxy-γ-amino acids and (3S,4S)-Statine, derived from L-Leucine, is found in important aspartic proteases inhibitors like Pepstatin A. We developed a new synthesis of (3S,4S)-Statine based on the highly
Externí odkaz:
https://doaj.org/article/661aa250856b4d2f9bf8374731d0c049
Autor:
Charlène Gadais, Evelyne Chelain, Nathalie Lensen, Thierry Brigaud, Sitan Diarra, Clément Sanchez, Andrea Bordessa
Publikováno v:
Organic & Biomolecular Chemistry. 19:6771-6775
Enantiopure α-Tfm-proline and α-Tfm-pipecolic acid were synthesized starting from commercially available diesters and ethyl trifluoroacetate. A Strecker type reaction on intermediate chiral Tfm-oxazolo-pyrrolidine and -piperidine provided the corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb7f7454019c1346f66c7c839445ef8
https://doi.org/10.1039/d1ob01173a
https://doi.org/10.1039/d1ob01173a
Autor:
Charlène Gadais, Clément Sanchez, Sylvaine Girard, Gregory Chaume, Thierry Brigaud, Evelyne Chelain
Publikováno v:
Organic Letters. 23:382-387
The straightforward synthesis of enantiopure 5-(R)-and 5-(S)-trifluoromethylproline is reported. The key steps are a Ruppert-Prakash reagent addition on l-pyroglutamic esters followed by an elimination reaction and a selective reduction. The solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1846ac1eb055d0cc9b8d3290e2f77c11
https://doi.org/10.1021/acs.orglett.0c03880
https://doi.org/10.1021/acs.orglett.0c03880
Publikováno v:
ChemBioChem. 23
Fluorinated non-natural amino acids are useful tools for improving the bioavailability of peptides but can also serve as fluorinated probes in 19 F NMR-based enzymatic assays. We report herein that the use of the non-natural α-quaternarized (R)-α-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d13a90d32f78fd26aa6f01d856ba61
https://doi.org/10.1002/cbic.202100470
https://doi.org/10.1002/cbic.202100470
Autor:
Clément A, Sanchez, Charlène, Gadais, Grégory, Chaume, Sylvaine, Girard, Evelyne, Chelain, Thierry, Brigaud
Publikováno v:
Organic letters. 23(2)
The straightforward synthesis of enantiopure 5-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5893d3421d123317dc79f9d22a170f53
https://pubmed.ncbi.nlm.nih.gov/33369434
https://pubmed.ncbi.nlm.nih.gov/33369434
Autor:
Oussema Ouerfelli, Rafâa Besbes, Evelyne Chelain, Julien Pytkowicz, Thierry Brigaud, Julien Simon
Publikováno v:
Organic letters. 22(8)
A straightforward synthesis of enantiopure α-trifluoromethyl aziridine-2-carboxylic acid (α-TfmAzy) is reported from a trifluoropyruvate derived enantiopure oxazolidine. A key Strecker-type synthetic step and a late cyanide basic hydrolysis gave th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8789d99c9970c7e7a849b8429f83b9d0
https://pubmed.ncbi.nlm.nih.gov/32216364
https://pubmed.ncbi.nlm.nih.gov/32216364
Autor:
Julien Pytkowicz, Emmanuelle Devillers, Thierry Brigaud, Evelyne Chelain, Charlène Gadais, Vincent Gasparik
Publikováno v:
ChemBioChem. 19:1026-1030
In order to achieve accurate determination of the local hydrophobicity increases in peptide sequences produced by incorporation of trifluoromethylated amino acids (TfmAAs), the chromatographic hydrophobicity indexes (ϕ0 ) of three series of tripepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46763fca8c8621f2ca701ac8dec175d
https://doi.org/10.1002/cbic.201800088
https://doi.org/10.1002/cbic.201800088
Publikováno v:
European Journal of Organic Chemistry. 2017:246-251
Among the fluorinated noncanonical amino acids, l-trifluoromethionine (TFM) and l-S-(trifluoromethyl)cysteine (TfmCys), fluorinated analogues of methionine and cysteine, are of particular interest because of their ability to locally increase the hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8361151c93bcb9b00b4e524fb5be497
https://doi.org/10.1002/ejoc.201601318
https://doi.org/10.1002/ejoc.201601318
Autor:
Lucie Caillon, Emmanuelle Devillers, Anais R. F. Hoffmann, Vincent Gasparik, Evelyne Chelain, Olivier Lequin, Thierry Brigaud, Alexandra Botz, Lucie Khemtémourian
Publikováno v:
Biopolymers. 104:601-610
The extracellular deposition of insoluble amyloid fibrils resulting from the aggregation of the amyloid-β (Aβ) is a pathological feature of neuronal loss in Alzheimer's disease (AD). Numerous small molecules have been reported to interfere with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db7cb0b01a10e64e960b7a7868bfca5
https://doi.org/10.1002/bip.22670
https://doi.org/10.1002/bip.22670
Publikováno v:
Amino Acids
Amino Acids, Springer Verlag, 2016, 6, pp.1457-1468. ⟨10.1007/s00726-016-2200-9⟩
Amino Acids, Springer Verlag, 2016, 6, pp.1457-1468. ⟨10.1007/s00726-016-2200-9⟩
Considering the increasing importance of fluorinated peptides, the development of efficient and reliable synthetic methods for the incorporation of unnatural fluorinated amino acids into peptides is a current matter of interest. In this study, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae06a4b1c7dd9162482c430cb999017d
