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of 16
pro vyhledávání: '"Evelyn Yanez"'
Autor:
Evelyn Yanez, Joseph W. Lubach, Daniel P. Dobson, Jackson D. Pellet, Andreas Stumpf, Jerry Tso
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3037-3046
Micronization by air jet milling is often used to produce drug substance particles of acceptable respirable size for use in dry powder inhaler formulations. The energy from this process often induces surface disordered sites on the micronized particl
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Autor:
Virender Kumar, Bharti Sethi, Evelyn Yanez, Dennis H. Leung, Yashwardhan Y. Ghanwatkar, Jonathan Cheong, Jerry Tso, Ajit S. Narang, Karthik Nagapudi, Ram I. Mahato
Publikováno v:
International journal of pharmaceutics. 615
In this study, we evaluated the aerodynamic performance, dissolution, and permeation behavior of micronized fluticasone propionate (FP) and magnesium stearate (MgSt) binary mixtures. Micronized FP was dry mixed with 2% w/w MgSt using a tumble mixer a
Autor:
Nivedita Shetty, Jonathan Hou, Jag Shur, Evelyn Yanez, Karthik Nagapudi, Ajit S. Narang, Changquan Calvin Sun, Joan Cheng
Publikováno v:
Journal of pharmaceutical sciences. 111(4)
High drug load inhalable particles were prepared by co-spray drying a hydrophobic, crystalline, small molecule drug with various lipid or phospholipid excipients at a 9:1 molar ratio to understand the primary drivers of aerosol performance. The effec
Autor:
Evelyn Yanez, Andrea Pirzkall, Joseph A. Ware, Kari M. Morrissey, Shuguang Ma, Nicholas Siebers, Roland Morley, Stephanie Royer-Joo, Hoa Le, Lori Joas, Julia Suchomel, Xiaorong Liang, Rui Zhu, Edward Yost, Laurent Salphati
Publikováno v:
British Journal of Clinical Pharmacology
AIMS Navoximod (GDC-0919, NLG-919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance associated with cancer. The primary objectives of this study were to assess navoximod's absolut
Autor:
Evelyn Yanez, Eric J. Munson, Changquan Calvin Sun, Shubhajit Paul, Julie L. Calahan, Daniel DeNeve
Publikováno v:
Pharmaceutical development and technology. 26(2)
Magnesium stearate (MgSt) is a widely used pharmaceutical lubricant in tablet manufacturing. However, batch-to-batch variability in hydrate form and surface area can lead to inconsistency in tablet performance. In this work, several unique MgSt sampl
Publikováno v:
International Journal of Pharmaceutics. 521:337-345
This paper explores the effectiveness of resonant acoustic mixing RAM for screening and scale up of cocrystals. 16 cocrystal systems were selected as test cases based on previous literature precedent. A 96 well plate set up in conjunction with zircon
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Autor:
Barbara L. Adams, Jerry Lipka, Stacy Clark, Joan Parker Webster, Maureen P. Hogan, Doreen Lacy, Evelyn Yanez
Publikováno v:
Anthropology Education Quarterly. 36:367-385
Math in a Cultural Context (MCC) was developed from ethnographic work with Yup'ik elders and teachers. The need for culturally based curricula seems obvious to those in the field of educational anthropology, but not necessarily to policymakers. Two c