VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology

Autor: Sam W. Lee, Fenja L. Gierschek, Susanne M. Kooistra, Randolph J. Noelle, Maaike L. Brummer, Tiago Medeiros-Furquim, Bart J. L. Eggen, Malte Borggrewe, Tegan A. Otto, Elizabeth C. Nowak, Evelyn Wesseling, Jon D. Laman

Publikováno v: Acta neuropathologica communications, 9(1):91, 91-109. BioMed Central Ltd.
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid cells regulates cytokine production, chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce58e84545a9db811d42f63609c1b58
https://research.rug.nl/en/publications/ac4daf39-ce9b-44b1-b26f-012beb8cb19a

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

Autor: Emma Gerrits, Evelyn Wesseling, Erik Boddeke, Maaike L. Brummer, Susanne M. Kooistra, Bart J. L. Eggen, Xiaoming Zhang, Tjalling W. Nijboer, Nieske Brouwer, Marissa L. Dubbelaar, Yang Heng, Hilmar R. J. van Weering

Publikováno v: Zhang, X, Heng, Y, Kooistra, S M, van Weering, H R J, Brummer, M L, Gerrits, E, Wesseling, E M, Brouwer, N, Nijboer, T W, Dubbelaar, M L, Boddeke, E W G M & Eggen, B J L 2021, ' Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement ', Glia, vol. 69, no. 3, pp. 729-745 . https://doi.org/10.1002/glia.23925
Glia, 1-17. Wiley
ISSUE=3;STARTPAGE=1;ENDPAGE=17;ISSN=0894-1491;TITLE=Glia
Glia

The DNA excision repair protein Ercc1 is important for nucleotide excision, double strand DNA break, and interstrand DNA crosslink repair. In constitutive Ercc1‐knockout mice, microglia display increased phagocytosis, proliferation and an enhanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2f2ea5eddf5575678806a215aa93f7
https://curis.ku.dk/ws/files/255453491/glia.23925.pdf

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

Autor: Susanne M. A. van der Pol, Divya Raj, Wandert Schaafsma, Nieske Brouwer, Helga E. de Vries, Knut Biber, Hendrikus Boddeke, Wilfred F. A. den Dunnen, Ronald van Os, Bart J. L. Eggen, Jill Moser, Hisko Oeseburg, Inge R. Holtman, Evelyn Wesseling

Publikováno v: Raj, D D, Moser, J, van der Pol, S M A, van Os, R P, Holtman, I R, Brouwer, N, Oeseburg, H, Schaafsma, W, Wesseling, E M, den Dunnen, W, Biber, K P, de Vries, H E, Eggen, B J & Boddeke, H W G M 2015, ' Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening ', Aging Cell, vol. 14, no. 6, pp. 1003-1013 . https://doi.org/10.1111/acel.12370
Aging Cell, 14(6), 1003-1013. Wiley-Blackwell
Aging Cell
Aging Cell, 14(6), 1003-1013. Wiley

Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082b8f61a174e7e5be80839c821b1c0d
https://doi.org/10.1111/acel.12370

Interleukin-6-type cytokines in neuroprotection and neuromodulation: oncostatin M, but not leukemia inhibitory factor, requires neuronal adenosine A1 receptor function

Autor: Knut Biber, Ana M. Sebastião, Yuko Sekino, Raquel B. Dias, Shamsudheen Moidunny, Hendrikus Boddeke, Evelyn Wesseling

Publikováno v: Journal of Neurochemistry. 114:1667-1677

Neuroprotection is one of the prominent functions of the interleukin (IL)-6-type cytokine family, for which the underlying mechanism(s) are not fully understood. We have previously shown that neuroprotection and neuromodulation mediated by IL-6 requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54e9c2628dfcf952a32cc2428d8992c9
https://doi.org/10.1111/j.1471-4159.2010.06881.x

Characterization and comparison of osteoblasts derived from mouse embryonic stem cells and induced pluripotent stem cells

Autor: Veerakumar Balasubramaniyan, Ming San Ma, Roel Kuijer, Anneriek de Vries, Evelyn Wesseling, Sjef Copray, Vishnu Kannan, Arjan Vissink, Marcin Czepiel, Gerry M. Raghoebar

Publikováno v: Journal of bone and mineral metabolism, 35(1), 21-30. SPRINGER JAPAN KK

New developments in stem cell biology offer alternatives for the reconstruction of critical-sized bone defects. One of these developments is the use of induced pluripotent stem (iPS) cells. These stem cells are similar to embryonic stem (ES) cells, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3075fe6d247c68cd19e6656a3995cd3d
https://pubmed.ncbi.nlm.nih.gov/26747612