Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Evelyn R Barrack"'
Autor:
Vidyavathi Reddy, Asm Iskander, Clara Hwang, George Divine, Mani Menon, Evelyn R Barrack, G Prem-Veer Reddy, Sahn-Ho Kim
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Externí odkaz:
https://doaj.org/article/607ad49b375c445eb2d9bad612ef676d
Autor:
Lucas Maahs, Bertha E Sanchez, Nilesh Gupta, Meredith Van Harn, Evelyn R Barrack, Prem-Veer Reddy, Clara Hwang
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222510 (2019)
About half of the patients treated with docetaxel in the setting of metastatic castration-resistant prostate cancer (CRPC) are non-responders. Therefore, a marker of response would be beneficial for clinical decision-making. We evaluated class III β
Externí odkaz:
https://doaj.org/article/e0f5a0edf6e64433a303f8e2b36d9d30
Autor:
Shalini Murthy, Min Wu, V Uma Bai, Zizheng Hou, Mani Menon, Evelyn R Barrack, Sahn-Ho Kim, G Prem-Veer Reddy
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56692 (2013)
BACKGROUND: The androgen receptor (AR) plays a critical role in the proliferation of prostate cancer cells. However, its mechanism of action in proliferation remains unknown. An understanding of the mechanism of AR action in proliferation may lead to
Externí odkaz:
https://doaj.org/article/91e1720d030b4b8b8a29df0ed72a75bd
Autor:
V Uma Bai, Ok Hwang, George W Divine, Evelyn R Barrack, Mani Menon, G Prem-Veer Reddy, Clara Hwang
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34875 (2012)
The identification of a blood-based diagnostic marker is a goal in many areas of medicine, including the early diagnosis of prostate cancer. We describe the use of averaged differential display as an efficient mechanism for biomarker discovery in who
Externí odkaz:
https://doaj.org/article/447207c9a92c4946a0cd36e4786f7b2b
Autor:
Evelyn R. Barrack, Lucas Maahs, Clara Hwang, Prem Veer Reddy, Nilesh S. Gupta, Bertha E. Sanchez, Meredith Van Harn
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0222510 (2019)
PLoS ONE, Vol 14, Iss 10, p e0222510 (2019)
About half of the patients treated with docetaxel in the setting of metastatic castration-resistant prostate cancer (CRPC) are non-responders. Therefore, a marker of response would be beneficial for clinical decision-making. We evaluated class III β
Autor:
Evelyn R. Barrack, Asm Iskander, Clara Hwang, Sahn-Ho Kim, Mani Menon, George Divine, Vidyavathi Reddy, G. Prem Veer Reddy
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
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PLoS ONE
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Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Autor:
Vidyavathi Reddy, Nicholas Ciavattone, Nathan McKenty, Mani Menon, Sahn Ho Kim, G. Prem Veer Reddy, Evelyn R. Barrack, Min Wu
Publikováno v:
Journal of Biological Chemistry. 290:25522-25533
Androgen receptor (AR) plays a role in maintaining telomere stability in prostate cancer cells, as AR inactivation induces telomere dysfunction within 3 h. Since telomere dysfunction in other systems is known to activate ATM (ataxia telangiectasia mu
Autor:
Evelyn R. Barrack, M. Menon, Junying Zhou, Vidyavathi Reddy, G. Prem Veer Reddy, Sahn Ho Kim, Michelle Richardson
Publikováno v:
Aging (Albany NY)
Telomeres protect the ends of linear chromosomes from being recognized as damaged DNA, and telomere stability is required for genome stability. Here we demonstrate that telomere stability in androgen receptor (AR)-positive LNCaP human prostate cancer
Autor:
Kannagi Chinnakannu, Evelyn R. Barrack, Mani Menon, Sahn Ho Kim, V. Uma Bai, Shalini Murthy, G. Prem Veer Reddy, Arun Sivanandam
Publikováno v:
Journal of Cellular Physiology. 226:1889-1896
Prostate cancer is the most frequently diagnosed non-skin cancer and second leading cause of cancer deaths in American men (Jemal et al., 2009). Androgen, by activating the androgen receptor (AR), plays a pivotal role in prostate cancer cell prolifer
Publikováno v:
The Prostate. 71:857-871
BACKGROUND Radical prostatectomy (RP) is not curative if patients have undetected metastatic prostate cancer. Markers that indicate the presence of metastatic disease would identify men who may benefit from systemic adjuvant therapy. Our approach was