Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Evelyn K Lambe"'
Publikováno v:
eLife, Vol 5 (2016)
The activity of serotonin (5-HT) neurons is critical for mood regulation. In a mouse model of chronic social isolation, a known risk factor for depressive illness, we show that 5-HT neurons in the dorsal raphe nucleus are less responsive to stimulati
Externí odkaz:
https://doaj.org/article/d4f625d8ad2f4c76850be009c1bb38cd
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors. These neurons in mouse association cortex are distinctive morphologically
Externí odkaz:
https://doaj.org/article/36dd4bb276c94ce68954899c68654a9e
Publikováno v:
Frontiers in Neural Circuits, Vol 9 (2015)
Externí odkaz:
https://doaj.org/article/90950194e9da48fa881fbf0e41253849
Autor:
Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene
Externí odkaz:
https://doaj.org/article/f374cbbc47054ea0a3ea6f1c0e8deae1
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22799 (2011)
Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin syst
Externí odkaz:
https://doaj.org/article/9e5429374df34e03a647171db14fe77e
Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats.
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9261 (2010)
There is a large sex difference in the prevalence of attention deficit disorder; yet, relatively little is known about sex differences in the development of prefrontal attention circuitry. In male rats, nicotinic acetylcholine receptors excite cortic
Externí odkaz:
https://doaj.org/article/7d746bc450374b8b939adcc32602e077
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108824- (2024)
Summary: Associating contexts with rewards depends on hippocampal circuits, with local inhibitory interneurons positioned to play an important role in shaping activity. Here, we demonstrate that the encoding of context-reward memory requires a ventra
Externí odkaz:
https://doaj.org/article/8f75e94a077c4b24a22ca007debd6a98
Autor:
Sridevi Venkatesan, Tianhui Chen, Yupeng Liu, Eric E. Turner, Shreejoy J. Tripathy, Evelyn K. Lambe
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105992- (2023)
Summary: Attention depends on cholinergic excitation of prefrontal neurons but is sensitive to perturbation of α5-containing nicotinic receptors encoded by Chrna5. However, Chrna5-expressing (Chrna5+) neurons remain enigmatic, despite their potentia
Externí odkaz:
https://doaj.org/article/938146cb44344155b648b41bc1833e9a
SUMMARYAssociating contexts with rewards depends on hippocampal circuits, with local inhibitory interneurons positioned to play an important role in shaping activity. Here, we hypothesize that the encoding of context-reward memory requires a ventral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8daa2a9d8f790e7351d1723432292c04
https://doi.org/10.1101/2023.04.27.538595
https://doi.org/10.1101/2023.04.27.538595
Autor:
Ashlea A. Morgan, Nuno D. Alves, Gregory S. Stevens, Tamanna T. Yeasmin, Alexandra Mackay, Saige Power, Derya Sargin, Carla Hanna, Arwa L. Adib, Annette Ziolkowski-Blake, Evelyn K. Lambe, Mark S. Ansorge
Publikováno v:
bioRxiv
The medial prefrontal cortex (mPFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin project to the mPFC, and serotonergic drugs influence emotion and cognition. Yet, the specific roles of endogenous serotonin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a73827ec9515913085af7e13d7e84b
https://europepmc.org/articles/PMC10081203/
https://europepmc.org/articles/PMC10081203/