Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Evelyn J Hyde"'
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Autor:
Kerry L. Hilligan, Shiau-Choot Tang, Evelyn J. Hyde, Elsa Roussel, Johannes U. Mayer, Jianping Yang, Kirsty A. Wakelin, Alfonso J. Schmidt, Lisa M. Connor, Alan Sher, Andrew S. MacDonald, Franca Ronchese
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and mon
Externí odkaz:
https://doaj.org/article/d65f3d80f398424cae180d6d1bb01a61
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and routes of sensitisat
Externí odkaz:
https://doaj.org/article/c42293eae984498fbbfb7baf2b23a162
Autor:
Kirsty A. Wakelin, Greta R Webb, Frank Brombacher, Lisa M Connor, Alan Sher, Sventja von Daake, David Gallego-Ortega, Luis Munoz-Erazo, Jianping Yang, Franca Ronchese, Sally Chappell, Charles R. Mackay, Johannes U Mayer, Dragana Jankovic, Matthew R. Hepworth, Graham Le Gros, David Eccles, Shiau-Choot Tang, Jodie Chandler, Olivier Lamiable, Kerry L Hilligan, Samuel I Old, Evelyn J Hyde, Rita G. Domingues, Roxane Tussiwand
Publikováno v:
Nature Immunology. 22:1538-1550
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling depe
Autor:
Johannes U. Mayer, Kerry L. Hilligan, Jodie S. Chandler, David A. Eccles, Samuel I. Old, Rita G. Domingues, Jianping Yang, Greta R. Webb, Luis Munoz-Erazo, Evelyn J. Hyde, Kirsty A. Wakelin, Shiau-Choot Tang, Sally C. Chappell, Sventja von Daake, Frank Brombacher, Charles R. Mackay, Alan Sher, Roxane Tussiwand, Lisa M. Connor, David Gallego-Ortega, Dragana Jankovic, Graham Le Gros, Matthew R. Hepworth, Olivier Lamiable, Franca Ronchese
In the version of this article initially published, there were labeling errors in Fig. 8. In Fig. 8a, the top row, now reading “GSE43184:CD1c+ lung versus blood,” originally appeared as “GSE35457….” The bottom row, now reading “GSE35457:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff24999b9482f93856ec7fdd01b8fcba
https://hdl.handle.net/10453/167364
https://hdl.handle.net/10453/167364
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Autor:
Lisa M Connor, Kirsty A. Wakelin, Alfonso J Schmidt, Alan Sher, Kerry L. Hilligan, Andrew S. MacDonald, Johannes U Mayer, Shiau-Choot Tang, Jianping Yang, Elsa Roussel, Evelyn J Hyde, Franca Ronchese
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Hilligan, K L, Tang, S-C, Hyde, E J, Roussel, E, Mayer, J U, Yang, J, Wakelin, K A, Schmidt, A J, Connor, L M, Sher, A, MacDonald, A S & Ronchese, F 2020, ' Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles ', Nature Communications, vol. 11, no. 1, pp. 5637 . https://doi.org/10.1038/s41467-020-19463-9
Nature Communications
Hilligan, K L, Tang, S-C, Hyde, E J, Roussel, E, Mayer, J U, Yang, J, Wakelin, K A, Schmidt, A J, Connor, L M, Sher, A, MacDonald, A S & Ronchese, F 2020, ' Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles ', Nature Communications, vol. 11, no. 1, pp. 5637 . https://doi.org/10.1038/s41467-020-19463-9
Nature Communications
Antigen (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC subsets contribute uniquely in determining Th differentiation in pathogen-specific settings. Here, we use skin-relevant, fluoresce
Autor:
Johannes U, Mayer, Kerry L, Hilligan, Jodie S, Chandler, David A, Eccles, Samuel I, Old, Rita G, Domingues, Jianping, Yang, Greta R, Webb, Luis, Munoz-Erazo, Evelyn J, Hyde, Kirsty A, Wakelin, Shiau-Choot, Tang, Sally C, Chappell, Sventja, von Daake, Frank, Brombacher, Charles R, Mackay, Alan, Sher, Roxane, Tussiwand, Lisa M, Connor, David, Gallego-Ortega, Dragana, Jankovic, Graham, Le Gros, Matthew R, Hepworth, Olivier, Lamiable, Franca, Ronchese
Publikováno v:
Nature immunology. 22(12)
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11b
The skin environment controls local dendritic cell differentiation and function through innate IL-13
Autor:
Kerry L Hilligan, Luis Munoz-Erazo, Lisa M Connor, Sally Chappell, Alan Sher, Franca Ronchese, Charles R. Mackay, Olivier Lamiable, Graham Le Gros, Jianping Yang, Dragana Jankovic, Kirsty A. Wakelin, Matthew R. Hepworth, David Eccles, Greta R Webb, Frank Brombacher, Evelyn J Hyde, Jodie Chandler, Samuel I Old, Roxane Tussiwand, Rita G. Domingues, Johannes U Mayer, Shiau-Choot Tang
The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11blow migratory DC2s, a DC2 population unique to the dermis, requires STAT6- and KLF4-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3c3ad77cbcaf7b0a32bb495053eddc
https://doi.org/10.1101/2021.01.05.425466
https://doi.org/10.1101/2021.01.05.425466
Autor:
Alfonso J Schmidt, Sotaro Ochiai, Olivier Lamiable, Ryan Kyle, Graham Le Gros, Melanie Prout, Hidehiro Yamane, Evelyn J Hyde, Ruby F. White, Franca Ronchese, Ferdinand Jagot
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance T helper 2 (Th2) cells are defined by their ability to produce the hallmark cytokine IL-4. However, to mediate allergic inflammation in tissues, Th2 cells must secrete additional cytokines including IL-13 and IL-5. We used IL-4 and IL-13
Publikováno v:
BMC Immunology
BMC Immunology, Vol 20, Iss 1, Pp 1-14 (2019)
BMC Immunology, Vol 20, Iss 1, Pp 1-14 (2019)
Background Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie human allergic asthma. Several models are commonly used, employing different methods and routes of sensitisation, and
Autor:
Connie B. Gilfillan, Evelyn J Hyde, Franca Ronchese, Jianping Yang, Sabine Kuhn, Camille Baey, Christiane Ruedl
In the steady state, tumors harbor several populations of dendritic cells (DCs) and myeloid cells that are key regulators of the intratumoral immune environment. Among these cells, migratory CD103+ cross-presenting DCs are thought to be critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7bbcc20801c9b88469d94cfc7b0e84
http://hdl.handle.net/10220/49073
http://hdl.handle.net/10220/49073