Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Evelyn Bracho-Sanchez"'
Autor:
Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Elena G. Yarmola, Benjamin G. Keselowsky, Gregory A. Hudalla, Kyle D. Allen
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Objective Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3), where IDO increas
Externí odkaz:
https://doaj.org/article/e4cad2fb4f1445438b5bcb16caeb3f69
Autor:
Shaheen A. Farhadi, Evelyn Bracho-Sanchez, Margaret M. Fettis, Dillon T. Seroski, Sabrina L. Freeman, Antonietta Restuccia, Benjamin G. Keselowsky, Gregory A. Hudalla
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.
Externí odkaz:
https://doaj.org/article/99b77a528cc74b09b0fb7568fbf3a3a5
Autor:
Evelyn Bracho-Sanchez, Fernanda G. Rocha, Sean K. Bedingfield, Brittany D. Partain, Sabrina L. Macias, Maigan A. Brusko, Juan M. Colazo, Margaret M. Fettis, Shaheen A. Farhadi, Eric Y. Helm, Kevin Koenders, Alexander J. Kwiatkowski, Antonietta Restuccia, Bethsymarie Soto Morales, Arun Wanchoo, Dorina Avram, Kyle D. Allen, Craig L. Duvall, Shannon M. Wallet, Gregory A. Hudalla, Benjamin G. Keselowsky
Publikováno v:
Nature Biomedical Engineering.
The treatment of chronic inflammation with systemically administered anti-inflammatory treatments is associated with moderate-to-severe side effects, and the efficacy of locally administered drugs is short-lived. Here we show that inflammation can be
Autor:
Kevin Koenders, Matthew R. Carstens, Clive Wasserfall, Nikunj K. Agrawal, Abhinav P. Acharya, Benjamin G. Keselowsky, Evelyn Bracho-Sanchez, Jamal S. Lewis
Publikováno v:
Lab Chip
Lab on a chip, vol 21, iss 18
Lab on a chip, vol 21, iss 18
Microarrays, miniaturized platforms used for high-content studies, provide potential advantages over traditional in vitro investigation in terms of time, cost, and parallel analyses. Recently, microarrays have been leveraged to investigate immune cel
Autor:
Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Gregory A. Hudalla, Kyle D. Allen, Benjamin G. Keselowsky, Elena G. Yarmola
ObjectiveControlling joint inflammation can improve osteoarthritis (OA) symptoms; however, current treatments often fail to provide long-term effects. We have developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3). IDO conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4be42805f3383752284ef8e08468dc
https://doi.org/10.1101/2021.07.21.453247
https://doi.org/10.1101/2021.07.21.453247
Autor:
Brittany D. Partain, Antonietta Restuccia, Shaheen A. Farhadi, Kyle D. Allen, Kevin Koenders, Craig L. Duvall, Maigan A. Brusko, Shannon M. Wallet, Sean K. Bedingfield, Benjamin G. Keselowsky, Arun Wanchoo, Dorina Avram, Evelyn Bracho-Sanchez, Alexander J. Kwiatkowski, Fernanda Regina Godoy Rocha, Eric Y. Helm, Juan M. Colazo, Sabrina L. Macias, Margaret M. Fettis, Gregory A. Hudalla
Summary paragraphChronic inflammation underlies the onset, progression and associated pain of numerous diseases.(1) Current anti-inflammatory treatments administered systemically are associated with moderate-to-severe side effects, while locally admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f318354935a129650a149504dc0345fc
https://doi.org/10.1101/2021.05.07.443161
https://doi.org/10.1101/2021.05.07.443161
Autor:
Benjamin G. Keselowsky, Evelyn Bracho-Sanchez, Gregory A. Hudalla, Shaheen A. Farhadi, Sabrina Freeman
Publikováno v:
Bioconjugate Chemistry. 29:649-656
Enzymes are attractive as immunotherapeutics because they can catalyze shifts in the local availability of immunostimulatory and immunosuppressive signals. Clinical success of enzyme immunotherapeutics frequently hinges upon achieving sustained bioca
Autor:
Benjamin G. Keselowsky, Lirong Yang, Matthew R. Carstens, Evelyn Bracho-Sanchez, Lawrence P. Fernando, Jamal S. Lewis, Craig L. Duvall
Publikováno v:
Bioengineering & Translational Medicine
Poly(lactic‐co‐glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner. Micron‐sized PLG
Autor:
Elena G. Yarmola, Benjamin G. Keselowsky, Evelyn Bracho-Sanchez, Gregory A. Hudalla, Kyle D. Allen, Brittany D. Partain, Shaheen A. Farhadi
Publikováno v:
Osteoarthritis and Cartilage. 28:S130-S131
Autor:
Benjamin G. Keselowsky, Mark A. Wallet, Azadeh Hassanzadeh, Maigan A. Brusko, Evelyn Bracho-Sanchez
Publikováno v:
J Immunol Regen Med
Indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme responsible for catalyzing the rate limiting step of tryptophan catabolism, plays a critical role in immune cell suppression and tolerance. Indoleamine 2,3-dioxygenase-mediated depletion of t