Switching from branded to generic glatiramer acetate: 15-month GATE trial extension results

Autor: Evelyn van den Tweel, Jeffrey A. Cohen, Christian Wolf, Krzysztof Selmaj, Roel Mulder, Frederik Barkhof, David Egging, Janine Oberye, Anna N. Belova, Norbert P Koper

Publikováno v: Multiple Sclerosis, 23(14), 1909-1917. SAGE Publications Ltd
Selmaj, K, Barkhof, F, Belova, A N, Wolf, C, van den Tweel, E R W, Oberyé, J J L, Mulder, R, Egging, D F, Koper, N P, Cohen, J A & on behalf of the GATE study group 2017, ' Switching from branded to generic glatiramer acetate : 15-month GATE trial extension results ', Multiple Sclerosis, vol. 23, no. 14, pp. 1909-1917 . https://doi.org/10.1177/1352458516688956
Multiple Sclerosis (Houndmills, Basingstoke, England)

Background: Open-label 15-month follow-up of the double-blind, placebo-controlled Glatiramer Acetate clinical Trial to assess Equivalence with Copaxone® (GATE) trial. Objective: To evaluate efficacy, safety, and tolerability of prolonged generic gla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e9ed4de2c4d60a6e7d9e3d5dae9379
https://research.vumc.nl/en/publications/6d1e79f7-6544-4e88-998d-f081c2bec390

Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia–ischemia in the neonatal rat brain

Autor: Evelyn van den Tweel, Cora H. Nijboer, Frank van Bel, Annemieke Kavelaars, Cobi Jacoba Johanna Heijnen, Floris Groenendaal

Publikováno v: Journal of Neuroimmunology. 167:64-71

Background and purpose Production of nitric oxide is thought to play an important role in neuroinflammation. Previously, we have shown that combined inhibition of neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) can reduce hypoxia–isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f13493fb207e685d67d9cc1f6a42ff
https://doi.org/10.1016/j.jneuroim.2005.06.031

Redox state of near infrared spectroscopy-measured cytochrome aa3 correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig

Autor: Floris Groenendaal, Evelyn van den Tweel, Cacha Peeters-Scholte, Frank van Bel

Publikováno v: Experimental Brain Research. 156:20-26

Early detection of delayed cerebral energy failure may be important in the prevention of reperfusion injury of the brain after severe perinatal hypoxia-ischaemia (HI). This study investigated whether monitoring of the redox state of cytochrome aa(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6a9464b0ee98f5afb6ada9439a931e
https://doi.org/10.1007/s00221-003-1761-5

Inhibition of nNOS and iNOS following Hypoxia-Ischaemia Improves Long-Term Outcome but Does Not Influence the Inflammatory Response in the Neonatal Rat Brain

Autor: Floris Groenendaal, Evelyn van den Tweel, Cobi Jacoba Johanna Heijnen, Cacha Peeters-Scholte, Frank van Bel

Publikováno v: Developmental Neuroscience. 24:389-395

In this study, we tested the hypothesis that combined inhibition of nNOS and iNOS will reduce neuronal damage and the inflammatory response induced by perinatal hypoxia-ischaemia (HI). In 12-day-old rats, HI was induced by right carotid artery occlus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b30121a86af10fc9c4f1fcf7e4d6151
https://doi.org/10.1159/000069044

Selective inhibition of nuclear factor-kappaB activation after hypoxia/ischemia in neonatal rats is not neuroprotective

Autor: Cobi Jacoba Johanna Heijnen, Maria Stella Lombardi, Annemieke Kavelaars, Evelyn van den Tweel, Frank van Bel, Michael May, Floris Groenendaal

Publikováno v: Pediatric research. 59(2)

Activated nuclear factor-kappaB (NFkappaB) has been shown to increase transcription of several genes that could potentially contribute to neuronal damage, such as proinflammatory cytokines, chemokines, and inducible nitric oxide synthase. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a605a4809603afe601f706b2610c2e
https://pubmed.ncbi.nlm.nih.gov/16439584