Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Eveline Snelders"'
Autor:
Ben Auxier, Alfons J M Debets, Felicia Adelina Stanford, Johanna Rhodes, Frank M Becker, Francisca Reyes Marquez, Reindert Nijland, Paul S Dyer, Matthew C Fisher, Joost van den Heuvel, Eveline Snelders
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002278 (2023)
Sexual reproduction involving meiosis is essential in most eukaryotes. This produces offspring with novel genotypes, both by segregation of parental chromosomes as well as crossovers between homologous chromosomes. A sexual cycle for the opportunisti
Externí odkaz:
https://doaj.org/article/6466b45940c740e1b63f9aee85743c67
Autor:
Jianhua Zhang, Paul E. Verweij, Antonius J. M. M. Rijs, Alfons J. M. Debets, Eveline Snelders
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
With population genetic evidence of recombination ongoing in the natural Aspergillus fumigatus population and a sexual cycle demonstrated in the laboratory the question remained what the natural niche for A. fumigatus sex is. Composting plant-waste m
Externí odkaz:
https://doaj.org/article/536f7872b65e4887bcb61ed53772757f
Autor:
Sijmen E. Schoustra, Alfons J.M. Debets, Antonius J.M.M. Rijs, Jianhua Zhang, Eveline Snelders, Peter C. Leendertse, Willem J.G. Melchers, Anton G. Rietveld, Bas J. Zwaan, Paul E. Verweij
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 7, Pp 1347-1353 (2019)
Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus. Environmental resistance selection is a main route for Aspergillus spp. to acquire azole resistance. We investigated the presence of environmental hotspots fo
Externí odkaz:
https://doaj.org/article/770107f78d774edc881ad9a2470b4788
Autor:
Tobias Engel, Paul E. Verweij, Joost van den Heuvel, Dechen Wangmo, Jianhua Zhang, Alfons J.M. Debets, Eveline Snelders
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Aspergillus fumigatus is a saprobic fungus that causes a range of pulmonary diseases, some of which are characterised by fungal persistence such as is observed in cystic fibrosis (CF) patients. Creation of genetic variation is critical for A. fumigat
Externí odkaz:
https://doaj.org/article/de3d9b80d4fd468483906cd11dd6106d
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 1, Pp 176-178 (2019)
We investigated azole resistance in Aspergillus fumigatus in a tertiary reference hospital in the Netherlands during 1994–2016. The 5-year patient-adjusted proportion of resistance increased from 0.79% for 1996–2001 to 4.25% for 2002–2006, 7.17
Externí odkaz:
https://doaj.org/article/338bff355b5842c59b519610e2ac166b
Publikováno v:
Journal of Fungi, Vol 7, Iss 8, p 599 (2021)
In order to successfully infect or colonize human hosts or survive changing environments, Aspergillus fumigatus needs to adapt through genetic changes or phenotypic plasticity. The genomic changes are based on the capacity of the fungus to produce ge
Externí odkaz:
https://doaj.org/article/b1c87bcc885a45ed9e5e313aa050b52a
Autor:
Jianhua Zhang, Eveline Snelders, Bas J. Zwaan, Sijmen E. Schoustra, Jacques F. Meis, Karin van Dijk, Ferry Hagen, Martha T. van der Beek, Greetje A. Kampinga, Jan Zoll, Willem J. G. Melchers, Paul E. Verweij, Alfons J. M. Debets
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed. After heat shock, to which sexual but not asexual spores are highly
Externí odkaz:
https://doaj.org/article/946ea22cd3ba44e9814688dad8dc166a
Autor:
Jan W.M. van der Linden, Eveline Snelders, Greetje A. Kampinga, Bart J.A. Rijnders, Eva Mattsson, Yvette J. Debets-Ossenkopp, Ed J. Kuijper, Frank H. Van Tiel, Willem J.G. Melchers, Paul E. Verweij
Publikováno v:
Emerging Infectious Diseases, Vol 17, Iss 10, Pp 1846-1854 (2011)
The prevalence and spread of azole resistance in clinical Aspergillus fumigatus isolates in the Netherlands are currently unknown. Therefore, we performed a prospective nationwide multicenter surveillance study to determine the effects of resistance
Externí odkaz:
https://doaj.org/article/4c34b98de31f40928486bef95f819e5b
Autor:
Simone M T Camps, Bas E Dutilh, Maiken C Arendrup, Antonius J M M Rijs, Eveline Snelders, Martijn A Huynen, Paul E Verweij, Willem J G Melchers
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50034 (2012)
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. However, prolonged treatment may cause resistance to develop, which is associated with treatment failure. The azole target cyp51A is a hotspot for mut
Externí odkaz:
https://doaj.org/article/a0f56d7baf5d45fd85b31e063bd0b19f
Autor:
Eveline Snelders, Simone M T Camps, Anna Karawajczyk, Gijs Schaftenaar, Gert H J Kema, Henrich A van der Lee, Corné H Klaassen, Willem J G Melchers, Paul E Verweij
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31801 (2012)
BACKGROUND:Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, an environmental route of resistance de
Externí odkaz:
https://doaj.org/article/f0ad36d691be4c9ea5d08a7dd65fe8ae