Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eveline P. C. T. de Rijk"'
Autor:
Michelle L. Simons, Eveline P. C. T. de Rijk, Catherine A. Picut, Donald G. Stump, Amera K. Remick, George A. Parker
Publikováno v:
Toxicologic Pathology. 43:326-342
Histopathologic examination of the testis from juvenile rats is often necessary to characterize the safety of new drugs for pediatric use and is a required end point in male pubertal development and thyroid function assays. To aid in evaluation and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71ff61ddd952ff46bb7a0b135d67051
https://doi.org/10.1177/0192623314547279
https://doi.org/10.1177/0192623314547279
Autor:
Helle Lorentsen, Joost Lensen, Eveline P. C. T. de Rijk, Ankie Lambregts, Hetty van den Brink, Birgit Peter
Publikováno v:
Toxicologic Pathology. 42:1197-1211
The present study describes the normal histology of female reproductive organs during the estrous cycle in the Göttingen minipig. For this purpose, sexually mature females were sacrificed at different phases of the cycle (follicular/proliferation, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45b5ad46dded5ac30ca0c8eed8ecc68
https://doi.org/10.1177/0192623314526136
https://doi.org/10.1177/0192623314526136
Publikováno v:
Toxicologic pathology. 44(3)
In the literature, experimental data on sexual maturation of female Göttingen minipigs are lacking. This may impede a reliable evaluation of reproductive functioning, particularly in the young (immature) sow used in toxicity studies. To find suitabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb3546301590a16379da7be24f4405d
https://pubmed.ncbi.nlm.nih.gov/26883154
https://pubmed.ncbi.nlm.nih.gov/26883154
Autor:
Katharine M. Whitney, Axel Bube, Karen S. Regan, Régis Masson, Petrina Rogerson, Dianne M. Creasy, Hitoshi Kandori, Eveline P. C. T. de Rijk, Sabine Rehm, Thomas Nolte, Rachel Y. Reams, Maki Kuwahara
Publikováno v:
Toxicologic Pathology. 40:40S-121S
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North Am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1464838e4232b3d2b1e0c73386341c1
https://doi.org/10.1177/0192623312454337
https://doi.org/10.1177/0192623312454337
Publikováno v:
Toxicologic Pathology. 36:164S-170S
In toxicity studies, the nonhuman primate is often the species of choice to evaluate the toxicologic potential of chemicals and drugs. Especially in the case of effects on female reproductive organs and mammary glands, other animal species are less p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac80109c8dfa36c780bc0982a6f93342
https://doi.org/10.1177/0192623308326152
https://doi.org/10.1177/0192623308326152
Publikováno v:
Toxicologic Pathology. 36:108S-118S
As part of an overview of the female reproductive organs in the macaque monkey, the present paper presents normal placental development. Although normally not examined in routine toxicologic pathology, the interest in the macaque as a model for repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b275edb36105cf0c31d3e22d3889a6a8
https://doi.org/10.1177/0192623308326095
https://doi.org/10.1177/0192623308326095
Publikováno v:
Toxicologic Pathology. 35:395-404
The cynomolgus monkey ( Macaca fascicularis) is widely used in regulatory toxicity studies. Especially in studies on male contraception, the male reproductive tract can be an important target system. The aim of the present paper is to describe a prac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91737d75ef94c0f00a5a2466cabc89f
https://doi.org/10.1080/01926230701230346
https://doi.org/10.1080/01926230701230346
Autor:
Eric Van Esch, Ross P. Tarara, Charles E. Wood, Justin D. Vidal, Eberhard Buse, Eveline P. C. T. de Rijk, J. Mark Cline, Gerhard F. Weinbauer
The authors describe a selection of normal findings and common naturally occurring lesions in the reproductive system of female macaques, including changes in the ovaries, uterus, cervix, vagina, and mammary glands. Normal features of immature ovarie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b088224989c5bc2fc744e6fb59b3ba
https://europepmc.org/articles/PMC3070965/
https://europepmc.org/articles/PMC3070965/
Autor:
Sylvia W. M Greijdanus-van der Putten, Leo A. P. Ballering, Jan Kamerman, Diels J. van den Dobbelsteen, Eveline P. C. T. de Rijk, Eric Van Esch
Publikováno v:
Toxicologic pathology. 33(6)
As part of regulatory safety testing program, a 13-week oral toxicity study with a new antipsychotic drug candidate was performed in beagle dogs. During this study, dark red/brown feces were recorded in treated dogs and increases in liver parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df779ecfe1d83d4170765de87b8b3e4
https://pubmed.ncbi.nlm.nih.gov/16263697
https://pubmed.ncbi.nlm.nih.gov/16263697
Publikováno v:
Toxicologic pathology. 31(4)
Hyaline droplet formation in the proximal tubular cells of the kidney commonly occurs under different pathological conditions in experimental animals. In rats, intracytoplasmic hyaline droplet formation is predominantly associated with accumulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5233a72b40c69ce5b1c4451715e16ed
https://pubmed.ncbi.nlm.nih.gov/14585745
https://pubmed.ncbi.nlm.nih.gov/14585745