Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Autor: Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0211003 (2019)

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successf

Externí odkaz: https://doaj.org/article/f34212ee8a7f4fe08eb2f2189dbf0663

First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio).

Autor: Sohye Yoon, Suman Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou, Eveline M Weerdenburg, Astrid M van der Sar, Difei Wang, Christopher J Secombes, Steve Bird

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0126378 (2015)

Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that exist in t

Externí odkaz: https://doaj.org/article/bb7c7e275f5444ae85b56cebae012785

Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinum Customizes Its Virulence Mechanisms for Survival and Replication in Different Hosts

Autor: Gemma C. Langridge, Astrid M. van der Sar, Douwe Molenaar, Shahjahan Ali, Abdallah M. Abdallah, Nicholas R. Thomson, Sabir A. Adroub, Wilbert Bitter, Farania Rangkuti, Thomas D. Otto, Moataz Abd El Ghany, Eveline M. Weerdenburg, Arnab Pain, Kars ter Veen, Roy Ummels, Gunny van Stempvoort

Publikováno v: Weerdenburg, E M, Abdallah, A, Rangkuti, F, Abd El Ghany, M, Otto, T D, Adroub, S A, Molenaar, D, Ummels, R, Ter Veen, K, van Stempvoort, G, van der Sar, A M, Ali, S, Langridge, G C, Thomson, N R, Pain, A & Bitter, W 2015, ' Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts. ', Infection and Immunity, no. 83, 5, pp. 1778-1788 . https://doi.org/10.1128/IAI.03050-14
Infection and Immunity, 1778-1788. American Society for Microbiology
ISSUE=83;STARTPAGE=1778;ENDPAGE=1788;ISSN=0019-9567;TITLE=Infection and Immunity

The interaction of environmental bacteria with unicellular eukaryotes is generally considered a major driving force for the evolution of intracellular pathogens, allowing them to survive and replicate in phagocytic cells of vertebrate hosts. To test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7fe5fb013bc481e19c4271b8bd816
https://doi.org/10.1128/iai.03050-14

How do mycobacteria activate CD8(+) T cells?

Autor: Nicole N. van der Wel, Peter J. Peters, Eveline M. Weerdenburg

Publikováno v: Trends in microbiology. 18(1):1-10

CD8(+) T cells are activated upon presentation of antigens from the cytosol. Therefore, it was unclear how pathogenic mycobacteria could prime this type of lymphocyte, given that these microbes were thought to remain in phagosomes and, hence, be shie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15180dbf5375d8eafdc6f283afbcaac5
https://doi.org/10.1016/j.tim.2009.10.004

First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio)

Autor: Jun Zou, Christopher J. Secombes, Steve Bird, Suman Mitra, Astrid M. van der Sar, Difei Wang, Eveline M. Weerdenburg, Sohye Yoon, Ayham Alnabulsi, Cathy A. Wyse

Publikováno v: Yoon, S, Mitra, S, Wyse, C, Alnabulsi, A, Zou, J, Weerdenburg, E M, van der Sar, A M, Wang, D F, Secombes, C J & Bird, S 2015, ' First Demonstration of Antigen Induced Cytokine Expression by CD4-1(+) Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) ', PLoS ONE, vol. 10, no. 6, e0126378 . https://doi.org/10.1371/journal.pone.0126378
PLoS ONE, Vol 10, Iss 6, p e0126378 (2015)
PLoS ONE
PLoS ONE, 10(6):e0126378. Public Library of Science

Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that exist in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc19787d4885976c695462576bcf3ed6
https://research.vumc.nl/en/publications/8634d804-3d79-427e-b475-d6e8a1d535bb