Nanoemulsion Improves Antinociceptive Activity of HP1, a Benzopyran from Hypericum polyanthemum

Autor: Stela Maris Kuze Rates, Gilsane Lino von Poser, Helder Ferreira Teixeira, Henrique Bridi, Eveline Dischkaln Stolz, Gabriela de Carvalho Meirelles

Publikováno v: Planta Medica International Open. 4:e82-e88

The impact of nanoemulsification on the antinociceptive effect of benzopyran HP1 in a mice hot plate test was investigated. For comparison, the same experiments were performed with HP1-free form. The durability of the antinociceptive effect was analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df4cf90610450c28fc5a0c5dd80897c2
https://doi.org/10.1055/s-0043-119759

Medicinal plants for the 'nerves': a review of ethnobotanical studies carried out in South Brazil

Autor: Stela Maris Kuze Rates, Liz G. Müller, Mara Rejane Ritter, Andressa Verdum Gross, Eveline Dischkaln Stolz

Publikováno v: Acta Botanica Brasilica, Volume: 33, Issue: 2, Pages: 269-282, Published: 19 JUN 2019
Acta Botanica Brasilica v.33 n.2 2019
Acta Botanica Brasilica
Sociedade Botânica do Brasil (SBB)
instacron:SBB
Acta Botânica Brasílica
Acta Botanica Brasilica, Issue: ahead, Published: 19 JUN 2019

Among the medicinal purposes for which plants have been used is the treatment of “nerves". The objective of this study was to search for species of plants used in the state of Rio Grande do Sul (South Brazil) for the relief of symptoms related to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d2b127eb214724d580521380f1cf59
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062019000200269&lng=en&tlng=en

Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species

Autor: Stela Maris Kuze Rates, Henrique Bridi, Letícia Guerini, Bianca Elingson da Silva Costa, Eveline Dischkaln Stolz, Gilsane Lino von Poser, Francisco Maikon Corrêa de Barros

Publikováno v: Chemistrybiodiversity. 15(11)

The south Brazilian Hypericum species have revealed the presence of a series of biologically active phloroglucinol derivatives. In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d6ecee4908fd6422f4179943794005
https://pubmed.ncbi.nlm.nih.gov/30156379

Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis

Autor: Eveline Dischkaln Stolz, François Noël, Stela Maris Kuze Rates, Liz G. Müller, Camila B. Antonio, Paola F. da Costa, Gilsane Lino von Poser

Publikováno v: Phytomedicine. 21(12):1684-1688

Uliginosin B is a natural phloroglucinol derivative, obtained from Hypericum species native to South America. Previous studies have shown that uliginosin B presents antidepressant-like and antinociceptive effects. Although its mechanism of action is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7314f9605a771da1f1e82a55f299aec

LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition

Autor: Thais E.T. Pompeu, Camila B. Antonio, Carlos A. M. Fraga, Eliezer J. Barreiro, Vivian Herzfeldt, Thaise S. Martins, Eveline Dischkaln Stolz, Andresa Heemann Betti, Stela Maris Kuze Rates, François Noël

Publikováno v: Behavioural pharmacology. 28(1)

Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ba3db7755eb453456cd241b1cced01
https://pubmed.ncbi.nlm.nih.gov/27755061