Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Eveline Barbieri"'
Autor:
Ling Tao, Mahmoud A. Mohammad, Giorgio Milazzo, Myrthala Moreno-Smith, Tajhal D. Patel, Barry Zorman, Andrew Badachhape, Blanca E. Hernandez, Amber B. Wolf, Zihua Zeng, Jennifer H. Foster, Sara Aloisi, Pavel Sumazin, Youli Zu, John Hicks, Ketan B. Ghaghada, Nagireddy Putluri, Giovanni Perini, Cristian Coarfa, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical mo
Externí odkaz:
https://doaj.org/article/f46634316a174b53a1daa084ab8c5d23
Autor:
Joanna S. Yi, Oscar Sias-Garcia, Nicole Nasholm, Xiaoyu Hu, Amanda Balboni Iniguez, Matthew D. Hall, Mindy Davis, Rajarshi Guha, Myrthala Moreno-Smith, Eveline Barbieri, Kevin Duong, Jessica Koach, Jun Qi, James E. Bradner, Kimberly Stegmaier, William A. Weiss, W. Clay Gustafson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 6, Pp 624-633 (2021)
Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription. Here we sought to identify
Externí odkaz:
https://doaj.org/article/e7ee05c4dfde46b7a9eedd9150ea3b8c
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Ling Tao, Myrthala Moreno‐Smith, Rodrigo Ibarra‐García‐Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs event
Externí odkaz:
https://doaj.org/article/0d8406c5d32841488bb0468840a3531b
Autor:
Jennifer H. Foster, Eveline Barbieri, Linna Zhang, Kathleen A. Scorsone, Myrthala Moreno-Smith, Peter Zage, Terzah M. Horton
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6565 (2021)
Pevonedistat is a neddylation inhibitor that blocks proteasomal degradation of cullin–RING ligase (CRL) proteins involved in the degradation of short-lived regulatory proteins, including those involved with cell-cycle regulation. We determined the
Externí odkaz:
https://doaj.org/article/674cae13e9fc4d49be3e1534645fd75f
Autor:
Zaowen Chen, Yunfu Lin, Eveline Barbieri, Sue Burlingame, John Hicks, Andrew Ludwig, Jason M. Shohet
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 8, Pp 753-762 (2009)
Neuroblastoma is derived from neural crest precursor components of the peripheral sympathetic nervous system and accounts for more than 15% of all pediatric cancer deaths. A clearer understanding of the molecular basis of neuroblastoma is required fo
Externí odkaz:
https://doaj.org/article/81256befa12241f0b4807896ced30b6e
Autor:
Eveline Barbieri, Katleen De Preter, Mario Capasso, Peter Johansson, Tsz-Kwong Man, Zaowen Chen, Paris Stowers, Gian Paolo Tonini, Frank Speleman, Jason M Shohet
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79843 (2013)
Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Rece
Externí odkaz:
https://doaj.org/article/1c189849586945f49531493917b116fb
Autor:
Eveline Barbieri, Jason M. Shohet, Silke Paust, Eugene S. Kim, Vivien Sheehan, Sanjeev A. Vasudevan, Jan J. Molenaar, Rikhia Chakraborty, Yankai Zhang, Rana Nikzad, Kevin Aviles-Padilla, Linda Schild, Kathleen A. Scorsone, Ling Tao, Zaowen Chen, Anna Lakoma, Myrthala Moreno-Smith
Survivin protein determination in multiple neuroblastoma lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324b38f5884525187183b05cbff54dee
https://doi.org/10.1158/1078-0432.22468167
https://doi.org/10.1158/1078-0432.22468167
Autor:
Eveline Barbieri, Jason M. Shohet, Silke Paust, Eugene S. Kim, Vivien Sheehan, Sanjeev A. Vasudevan, Jan J. Molenaar, Rikhia Chakraborty, Yankai Zhang, Rana Nikzad, Kevin Aviles-Padilla, Linda Schild, Kathleen A. Scorsone, Ling Tao, Zaowen Chen, Anna Lakoma, Myrthala Moreno-Smith
Purpose: mTORC1 inhibitors are promising agents for neuroblastoma therapy; however, they have shown limited clinical activity as monotherapy, thus rational drug combinations need to be explored to improve efficacy. Importantly, neuroblastoma maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e1854cdfe0feda0db08be80b004f1e
https://doi.org/10.1158/1078-0432.c.6526860
https://doi.org/10.1158/1078-0432.c.6526860
Autor:
Eveline Barbieri, Jason M. Shohet, Silke Paust, Eugene S. Kim, Vivien Sheehan, Sanjeev A. Vasudevan, Jan J. Molenaar, Rikhia Chakraborty, Yankai Zhang, Rana Nikzad, Kevin Aviles-Padilla, Linda Schild, Kathleen A. Scorsone, Ling Tao, Zaowen Chen, Anna Lakoma, Myrthala Moreno-Smith
Effect of combined RG7388 and temsirolimus on human PBMCs viability and apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b91f4594eef27eb72c162cabdfebfd
https://doi.org/10.1158/1078-0432.22468182
https://doi.org/10.1158/1078-0432.22468182