Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eveline Angstetra"'
Autor:
Janette Allison, Helen E. Thomas, Thomas W.H. Kay, Horst Bluethmann, Jonathan Chee, Emma M. Carrington, Kate L. Graham, Eveline Angstetra, Pere Santamaria, Balasubramanian Krishnamurthy, Lina Mariana
Publikováno v:
The Journal of Immunology. 187:1702-1712
TNF has been implicated in the pathogenesis of type 1 diabetes. When administered early in life, TNF accelerates and increases diabetes in NOD mice. However, when administered late, TNF decreases diabetes incidence and delays onset. TNFR1-deficient N
Autor:
Robyn Maree Slattery, Allison E. Irvin, Lorraine Elkerbout, Yuxing Zhao, Eveline Angstetra, Pere Santamaria, Thomas W.H. Kay, Kate L. Graham, Helen E. Thomas
Publikováno v:
Immunology & Cell Biology. 90:243-247
CD8(+) T cells kill pancreatic β-cells in a cell-cell contact-dependent mechanism in the non-obese diabetic mouse. CD4(+) T lymphocytes are also able to kill pancreatic β-cells, but they do not directly contact β-cells and may use another cell typ
Publikováno v:
Apoptosis. 14:1389-1404
Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets after transplantation. In type 1 diabetes, beta cells are destroyed by immunological mechanisms. In type 2 diabetes abnormal levels of metabolic factors
Autor:
Thomas W.H. Kay, Helen E. Thomas, Janette Allison, Sarah Emmett, Pere Santamaria, Kate L. Graham, Eveline Angstetra, Rochelle Ayala-Perez, Rima Darwiche, Nadine L. Dudek
Publikováno v:
Immunology & Cell Biology. 87:178-185
CD4(+) T cells can actively kill beta-cells in type I diabetes as well as help CD8(+) T cells become cytolytic. Cytokines have the potential to kill beta-cells, or upregulate Fas on beta-cells, and increase their susceptibility to FasL. We investigat
Autor:
Helen E. Thomas, Windy Irawaty, Nadine L. Dudek, Lina Mariana, Rochelle V Fernandes, Thomas W.H. Kay, Emma Jamieson, Eveline Angstetra
Publikováno v:
Immunology & Cell Biology. 84:20-27
Pro-inflammatory cytokines have been implicated in the death of pancreatic beta cells leading to type 1 diabetes. NIT-1 cells are an insulinoma cell line derived from mice expressing the SV40 large T antigen. These cells are a useful tool in analysis
Autor:
Thomas W H, Kay, Nadine L, Dudek, Kate, Graham, Eugene, Estella, Eveline, Angstetra, Mark D, McKenzie, Jan, Allison, Helen E, Thomas
Publikováno v:
Novartis Foundation symposium. 292
CD8+ T cells are the principal cellular mediators of beta cell destruction in the NOD mouse. Molecular mediators include perforin and granzymes from the cytotoxic granule, Fas ligand and pro-inflammatory cytokines. Our studies in NOD mice have shown
Autor:
Thomas W.H. Kay, Kate L. Graham, Helen E. Thomas, Jan Allison, Eveline Angstetra, Nadine L. Dudek, Mark D. McKenzie, Eugene Estella
Publikováno v:
Defining Optimal Immunotherapies for Type 1 Diabetes: Novartis Foundation Symposium 292
CD8+ T cells are the principal cellular mediators of beta cell destruction in the NOD mouse. Molecular mediators include perforin and granzymes from the cytotoxic granule, Fas ligand and pro-inflammatory cytokines. Our studies in NOD mice have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41b12b8bc329f46c5dd6316b943873db
https://doi.org/10.1002/9780470697405.ch6
https://doi.org/10.1002/9780470697405.ch6
Autor:
Andrew M. Lew, Pere Santamaria, Joseph A. Trapani, Thomas W.H. Kay, Nadine L. Dudek, Eveline Angstetra, Janette Allison, Lina Mariana, Helen E. Thomas, Eugene Estella, Robyn M. Sutherland
Publikováno v:
Diabetes. 55(9)
Cytotoxic T-cells are the major mediators of beta-cell destruction in type 1 diabetes, but the molecular mechanisms are not definitively established. We have examined the contribution of perforin and Fas ligand to beta-cell destruction using islet-sp