Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer’s Disease Mice

Autor: Sergio Catanozi, Giancarlo de Mattos Cardillo, Wagner F. Gattaz, Vanessa J. De-Paula, Eliza Hiromi Ikenaga, Daniel S. Kerr, Orestes Vicente Forlenza, Evelin L. Schaeffer, Luciana Rodrigues Costa

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Telomere length (TL) is a biomarker of cell aging, and its shortening has been linked to several age-related diseases. In Alzheimer's disease (AD), telomere shortening has been associated with neuroinflammation and oxidative stress. The majority of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f2b539e2fc33caf7cba9681591e776
https://doi.org/10.3233/jad-170838

Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus

Autor: Evelin L. Schaeffer, Wagner F. Gattaz

Publikováno v: Journal of Neural Transmission. 122:619-628

Adult neurogenesis occurs in the hippocampal dentate gyrus (DG) and lateral ventricles, and includes cell proliferation and neuronal differentiation, maturation and survival. In vitro studies suggest a role for phospholipase A2 (PLA2) in neuronal dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65cd8e0bf837d5150827feb05c748a4
https://doi.org/10.1007/s00702-014-1305-0

Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice

Autor: Mark J. West, Sergio Catanozi, Wagner F. Gattaz, Evelin L. Schaeffer

Publikováno v: Schaeffer, E L, Catanozi, S, West, M J & Gattaz, W F 2017, ' Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice ', Annals of Anatomy, vol. 209, pp. 51-60 . https://doi.org/10.1016/j.aanat.2016.10.002
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Pyramidal neuron loss in the hippocampal CM region is a very early hallmark of Alzheimer disease (AD). Lithium might be a therapeutic strategy for AD due to its neuroprotective and neurotrophic properties. This study used modern stereological techniq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4dcb61cb91c42aaf29ebe4b3e16be3
https://pubmed.ncbi.nlm.nih.gov/27777112

Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

Autor: Emanuelle R. da Silva, Wagner F. Gattaz, Evelin L. Schaeffer, Barbara de A. Novaes, Heni D. Skaf

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34:1381-1389

The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fa759da294720447475c3e8f044727
https://doi.org/10.1016/j.pnpbp.2010.08.019

Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme

Autor: Wagner F. Gattaz, Evelin L. Schaeffer

Publikováno v: Psychopharmacology. 198:1-27

Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939a89382bc70f0c8a56263c717d618e
https://doi.org/10.1007/s00213-008-1092-0