In depth behavioral phenotyping unravels complex motor disturbances in Cstb−/− mouse, a model for progressive myoclonus epilepsy type 1

Autor: Eveliina Pollari, Saara Tegelberg, Harry Björklund, Reetta Kälviäinen, Anna-Elina Lehesjoki, Antti Haapalinna

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 17 (2023)

Progressive myoclonus epilepsy type 1 (EPM1) is an autosomal recessively inherited childhood–adolescence onset neurodegenerative disease caused by mutations in the cystatin B (CSTB gene). The key clinical manifestation in EPM1 is progressive, stimu

Externí odkaz: https://doaj.org/article/1a6df0e2dd9f4a6a809d599f6b3d80be

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Autor: Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm

Publikováno v: IBRO Reports, Vol 6, Iss , Pp 74-86 (2019)

Inflammation is a prominent feature of the neuropathology of amyotrophic lateral sclerosis (ALS). Emerging evidence suggests that inflammatory cascades contributing to the disease progression are not restricted to the central nervous system (CNS) but

Externí odkaz: https://doaj.org/article/02325ea1922447b59859bac28b3eff53

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

Autor: Tom Jaspers, Eveliina Pollari, Elisabeth Rossaert, Matthew Jarpe, Ludo Van Den Bosch, Matthieu Moisse, Philip Van Damme, Katrien De Bock, Lawrence Van Helleputte

Publikováno v: Acta Neuropathologica Communications, 7 (1)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)

Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the affected neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ed081c2ed1f0deda5507d1f686effd
https://doi.org/10.1186/s40478-019-0750-2

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Autor: Philip Van Damme, Robert Prior, Ludo Van Den Bosch, Eveliina Pollari, Wim Robberecht

Publikováno v: Journal of Visualized Experiments.

Assessing the functionality of the nerve axon provides detailed information on the progression of neuromuscular disorders. Electrophysiological recordings provide a sensitive approach to measure nerve conduction in humans and rodent models. To broade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fd1cc8a6fb42fdb925c04da5dec3a9
https://doi.org/10.3791/57741-v

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Autor: Sighild Lemarchant, Velta Keksa-Goldsteine, Akihiko Takashima, Tarja Malm, Jari Koistinaho, Sanna Loppi, Sara Wojciechowski, Gary E. Landreth, Eveliina Pollari, Gundars Goldsteins, Piia Valonen, Juho Koponen, Paula Korhonen, Katja M. Kanninen, Mikko T. Huuskonen, Hiramani Dhungana

Publikováno v: Scientific Reports

Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauopathy or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cce9077492f6d48284653c6b7c7c546