Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Evelien Schurgers"'
Autor:
Evelien Schurgers, David C. Wraith
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immune response to exogenous proteins can overcome the therapeutic benefits of immunotherapies and hamper the treatment of protein replacement therapies. One clear example of this is haemophilia A resulting from deleterious mutations in the FVIII
Externí odkaz:
https://doaj.org/article/7b43f812124949209e9936a832697c09
Autor:
Ella R. Shepard, Anja Wegner, Elaine V. Hill, Bronwen R. Burton, Sarah Aerts, Evelien Schurgers, Brecht Hoedemaekers, Sky T. H. Ng, Heather B. Streeter, Lotta Jansson, David C. Wraith
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4+ T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (
Externí odkaz:
https://doaj.org/article/7703b64009ca4397b26c63d3a5da8fce
Autor:
Evelien Schurgers, Martijn Moorlag, Coenraad Hemker, Theo Lindhout, Hilde Kelchtermans, Bas de Laat
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149135 (2016)
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemos
Externí odkaz:
https://doaj.org/article/e088a42a6cee4c41b6746053631bef05
Autor:
Brecht Hoedemaekers, Evelien Schurgers, Sarah Aerts, Heather B Streeter, Ella R. Shepard, Sky T. H. Ng, Anja Wegner, Lotta Jansson, Elaine V. Hill, Bronwen R Burton, David C. Wraith
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Immunotherapy with antigen-processing independent T cell epitopes (apitopes) targeting autoreactive CD4+ T cells has translated to the clinic and been shown to modulate progression of both Graves’ disease and multiple sclerosis. The model apitope (
Autor:
William J Sanderson, David C. Wraith, Streeter Heather Barbara, Kirsty S. Nicolson, Evelien Schurgers, Katrien Pletinckx, Lotta Jansson
Publikováno v:
Blood advances. 6(7)
Haemophilia A (HA) is a blood clotting disorder caused by various genetic deficiencies in the factor VIII (FVIII) encoding F8 gene. Patients receiving FVIII replacement therapy are at risk of developing neutralizing antibodies (FVIII inhibitors) rend
Autor:
Theo Lindhout, Anne Bouwhuis, Bas de Laat, Marcus D. Lancé, Ganeshram Krishnamoorthy, Hilde Kelchtermans, Martijn Moorlag, Evelien Schurgers
Publikováno v:
Moorlag, M, Schurgers, E, Krishnamoorthy, G, Bouwhuis, A, Lindhout, T, Kelchtermans, H, Lance, M D & De Laat, B 2017, ' Near Patient Thrombin Generation in Patients Undergoing Elective Cardiac Surgery ', Journal of Applied Biomechanics, vol. 1, no. 6, pp. 613-25 . https://doi.org/10.1373/jalm.2016.022335
Journal of Applied Biomechanics, 1(6), 613-25. Human Kinetics Publishers Inc.
Journal of Applied Biomechanics, 1(6), 613-25. Human Kinetics Publishers Inc.
Background Measuring thrombin generation (TG) in plasma increasingly gained attention as a diagnostic tool in the field of thrombosis and hemostasis. To include the contribution of all blood cells, recently, the whole blood TG method was developed. M
Autor:
Anne Bouwhuis, H. Coenraad Hemker, Adam Miszta, Dana Huskens, Hilde Kelchtermans, Marcus D. Lancé, Evelien Schurgers, Bas de Laat, Leonie Pelkmans, Theo Lindhout
Publikováno v:
Kelchtermans, H, Pelkmans, L, Bouwhuis, A, Schurgers, E, Lindhout, T, Huskens, D, Miszta, A, Coenraad Hemker, H, Lancé, M D & De Laat, B 2016, ' Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions ', Thrombosis and Haemostasis, vol. 116, no. 1, pp. 134-145 . https://doi.org/10.1160/TH15-10-0801
Thrombosis and Haemostasis, 116(1), 134-145. Georg Thieme Verlag
Thrombosis and Haemostasis, 116(1), 134-145. Schattauer GmbH
Thrombosis and Haemostasis, 116(1), 134-145. Georg Thieme Verlag
Thrombosis and Haemostasis, 116(1), 134-145. Schattauer GmbH
SummaryAssays based on the formation of thrombin and fibrin are frequently used, and results are considered exchangeable in research/clinical settings. However, thrombin generation and fibrin formation do not always go hand in hand and flow profoundl
Autor:
Hilde Kelchtermans, Marisa Ninivaggi, Mark Roest, Steven J.R. Meex, Anna Selmeczi, Rinaldo van Meel, Joke Konings, Romy Kremers, Bas de Laat, Dana Huskens, Saartje Bloemen, Marie-Claire Kleinegris, Jasper A. Remijn, Philip G. de Groot, Rolf T. Urbanus, Evelien Schurgers
Publikováno v:
Thrombosis and Haemostasis, 115(6), 1081–1248. Schattauer GmbH
Thrombosis and Haemostasis, 115(6), 1109-1119. Georg Thieme Verlag
Thrombosis and Haemostasis, 115(6), 1109-1119. Georg Thieme Verlag
SummaryPhysical exercise is recommended for a healthy lifestyle. Strenuous exercise, however, may trigger the haemostatic system, increasing the risk of vascular thrombotic events and the incidence of primary cardiac arrest. Our goal was to study the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3e589ac85ef20a031636fb0eb8a2a2
https://dspace.library.uu.nl/handle/1874/346523
https://dspace.library.uu.nl/handle/1874/346523
Autor:
Bas de Laat, Martijn Moorlag, Evelien Schurgers, Coenraad Hemker, Hilde Kelchtermans, Theo Lindhout
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149135 (2016)
PLoS ONE
PLOS ONE, 11(2):e0149135. Public Library of Science
PLoS ONE
PLOS ONE, 11(2):e0149135. Public Library of Science
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemos
Autor:
Stéphanie Put, Alfons Billiau, Peter Hoet, Freya Mertens, Erik Verbeken, Ellen De Langhe, Evelien Schurgers, Jeroen Vanoirbeek, Benoit Nemery, Tania Mitera, Patrick Matthys
Publikováno v:
European Journal of Immunology. 42:3223-3234
Following immunization with collagen II (CII) in complete Freund's adjuvant (CFA), DBA/1 mice develop arthritis of major joints. This collagen-induced arthritis (CIA) is used as a model for rheumatoid arthritis (RA) in man. Inflammatory changes in lu