Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eve M. Burns"'
Publikováno v:
The Journal of Experimental Medicine
Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced proliferation and IL-2 production in response to the antigen compared with cells from young mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e870ce0811a746554cd367e07d69d182
http://europepmc.org/articles/PMC2213095
http://europepmc.org/articles/PMC2213095
Publikováno v:
The Journal of Experimental Medicine
With increasing age, the ability to produce protective antibodies in response to immunization declines, leading to a reduced efficacy of vaccination in the elderly. To examine the effect of age on the cognate function of CD4 T cells, we have used a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8b5a9aa3a59efe62247443702a835c
https://doi.org/10.1084/jem.20041395
https://doi.org/10.1084/jem.20041395
Publikováno v:
The Journal of Immunology. 172:5194-5199
Age-related decreases in immune function are thought to contribute to the reduced efficacy of vaccinations seen in elderly populations. Our previous in vitro studies demonstrated that naive CD4 T cells from aged TCR-transgenic mice proliferate less t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360f9fdfd86382b4cf4399aafff7470d
https://doi.org/10.4049/jimmunol.172.9.5194
https://doi.org/10.4049/jimmunol.172.9.5194
Autor:
Janine Morrissey, Bruce J. Dezube, James D. Dixon, William Weeden, Christopher O’Loughlin, Lisa A. Williams, Vern J. Choy, Jielin Zhang, Eve M. Burns, JoAnn Proper, Clyde S. Crumpacker, Frank B. Gelder, Paul J. Pickering
Publikováno v:
The Journal of Infectious Diseases. 187:500-503
(PE)HRG214 (HRG) is a polyclonal antibody preparation produced by immunization of goats with purified human immunodeficiency virus (HIV) antigens. In this phase I study, HRG was administered intravenously as a single dose (1, 2, 4, 8, or 16 mg/kg) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bf8d86844ed844b0948e96f8fb76c9
https://doi.org/10.1086/367710
https://doi.org/10.1086/367710
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(25)
Age-related declines in immune function have an impact on both primary and memory responses. In this study, we have examined the ability of naive CD4 T cells from young and aged T cell receptor transgenic mice to establish functional memory. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4121b30ef6912ac46c315e533d268cf9
https://pubmed.ncbi.nlm.nih.gov/14657384
https://pubmed.ncbi.nlm.nih.gov/14657384