Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Eve L, Coomber"'
Autor:
Sandra Van Puyvelde, Derek Pickard, Koen Vandelannoote, Eva Heinz, Barbara Barbé, Tessa de Block, Simon Clare, Eve L. Coomber, Katherine Harcourt, Sushmita Sridhar, Emily A. Lees, Nicole E. Wheeler, Elizabeth J. Klemm, Laura Kuijpers, Lisette Mbuyi Kalonji, Marie-France Phoba, Dadi Falay, Dauly Ngbonda, Octavie Lunguya, Jan Jacobs, Gordon Dougan, Stijn Deborggraeve
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Invasive non-typhoidal Salmonella (iNTS) infections are dominated by antibiotic resistant isolates of the sequence type (ST) 313. Here, the authors identify the ST313 sublineage II.1 in the Democratic Republic of the Congo exhibiting extensive drug r
Externí odkaz:
https://doaj.org/article/d03041f0c2d4477dbba22683cea763a0
Autor:
Paige M Mortimer, Esme Nichols, Joe Thomas, Rachna Shanbhag, Neha Singh, Eve L Coomber, Talat H Malik, Matthew C Pickering, Lyra Randzavola, William Rae, Sagar Bhattad, David C Thomas
Chronic Granulomatous Disease (CGD) is an inborn error of immunity characterised by opportunistic infection and sterile granulomatous inflammation. CGD is caused by a failure of reactive oxygen species (ROS) production by the phagocyte NADPH oxidase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bccbd2955c8c2759bcba10e3c6c2f683
https://doi.org/10.1101/2023.04.21.23286144
https://doi.org/10.1101/2023.04.21.23286144
Autor:
William, Rae, John M, Sowerby, Dorit, Verhoeven, Mariam, Youssef, Prasanti, Kotagiri, Natalia, Savinykh, Eve L, Coomber, Alexis, Boneparth, Angela, Chan, Chun, Gong, Machiel H, Jansen, Romy, du Long, Giorgia, Santilli, Ilenia, Simeoni, Jonathan, Stephens, Kejia, Wu, Marta, Zinicola, Hana Lango, Allen, Helen, Baxendale, Dinakantha, Kumararatne, Effrossyni, Gkrania-Klotsas, Selma C, Scheffler Mendoza, Marco Antonio, Yamazaki-Nakashimada, Laura Berrón, Ruiz, Cesar Mauricio, Rojas-Maruri, Saul O, Lugo Reyes, Paul A, Lyons, Anthony P, Williams, Daniel J, Hodson, Gail A, Bishop, Adrian J, Thrasher, David C, Thomas, Michael P, Murphy, Timothy J, Vyse, Joshua D, Milner, Taco W, Kuijpers, Kenneth G C, Smith
Publikováno v:
Science immunology. 7(74)
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human immunity is not defined. Here, in five unrelated families, we describe an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e24d9e414ab0c7f3318dd753ec84764
https://pubmed.ncbi.nlm.nih.gov/35960817
https://pubmed.ncbi.nlm.nih.gov/35960817
Autor:
Maria O. Levitin, Lettie E Rawlins, Gabriela Sanchez-Andrade, Osama A. Arshad, Stephan C. Collins, Stephen J. Sawiak, Phillip H. Iffland, Malin H.L. Andersson, Caleb Bupp, Emma L. Cambridge, Eve L. Coomber, Ian Ellis, Johanna C. Herkert, Holly Ironfield, Logan Jory, Perrine F. Kretz, Sarina G. Kant, Alexandra Neaverson, Esther Nibbeling, Christine Rowley, Emily Relton, Mark Sanderson, Ethan M. Scott, Helen Stewart, Andrew Y. Shuen, John Schreiber, Liz Tuck, James Tonks, Thorkild Terkelsen, Conny van Ravenswaaij-Arts, Pradeep Vasudevan, Olivia Wenger, Michael Wright, Andrew Day, Adam Hunter, Minal Patel, Christopher J. Lelliott, Peter B. Crino, Binnaz Yalcin, Andrew Crosby, Emma L. Baple, Darren W. Logan, Matthew E. Hurles, Sebastian S. Gerety
KPTN-related disorder (KRD) is an autosomal recessive disorder associated with germline variants in KPTN (kaptin), a component of the mTOR regulatory complex KICSTOR. To gain further insights into the pathogenesis of KRD, we analysed mouse knockout a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4cbb0278fd0279fd1689af80476ba3a
https://doi.org/10.1101/2022.07.15.500213
https://doi.org/10.1101/2022.07.15.500213
Autor:
Morgan Marsden, Gordon Dougan, Christine Hale, Mathew Clement, Eve L. Coomber, Jessica L. Forbester, Tao Dong, Amy Yeung, Lucy Chapman, Ian R. Humphreys, Sandra Dimonte, Dannielle Wellington, Charlotte Tolley, Simon Clare, Irina A. Udalova, Emily A. Lees
Publikováno v:
Journal of Virology
The inflammatory response to influenza A virus (IAV) participates in infection control but contributes to disease severity. After viral detection, intracellular pathways are activated, initiating cytokine production, but these pathways are incomplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a40ade6198a3d1309c674a294c2f4b6
https://pubmed.ncbi.nlm.nih.gov/32075938
https://pubmed.ncbi.nlm.nih.gov/32075938
Autor:
Derek Pickard, Simon Clare, Katherine Harcourt, Eva Heinz, Jan Jacobs, Dauly Ngbonda, Elizabeth J. Klemm, Nicole E. Wheeler, Emily A. Lees, Marie-France Phoba, Stijn Deborggraeve, Tessa De Block, Sushmita Sridhar, Barbara Barbé, Koen Vandelannoote, Dadi Falay, Octavie Lunguya, Lisette Mbuyi Kalonji, Eve L. Coomber, Laura Maria Francisca Kuijpers, Gordon Dougan, Sandra Van Puyvelde
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature communications
Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic resistance-associated sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9389a51c0e75a826f58f03706f8f9bf1
http://europepmc.org/articles/PMC6753159
http://europepmc.org/articles/PMC6753159
Publikováno v:
Nucleic Acids Research
Genome-wide association studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamental challenge remains to accurately identify the underlying causal genes and variants. Here, we describe an arrayed CRISPR screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4820cbb06868e2d919e1707309d7a29
http://europepmc.org/articles/PMC7736817
http://europepmc.org/articles/PMC7736817
Autor:
Hamoud Al-Mousa, James Lee, Giorgia Santilli, Kenneth G. C. Smith, Fowzan S. Alkuraya, Eve L. Coomber, Louis-Marie Charbonnier, Hasan Al-Dhekri, Anneliese O. Speak, Simon Clare, Anne E. Beenken, Andrea Schejtman, Elizabeth R. Dufficy, Talal A. Chatila, David C. Thomas, Adrian J. Thrasher
Short Summary The phagocyte respiratory burst is mediated by the phagocyte NADPH oxidase, a multi-protein subunit complex that facilitates production of reactive oxygen species and which is essential for host defence. Monogenic deficiency of individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea18756fea7700da80dce61c8c05c33a
Autor:
Fernanda Schreiber, Matthias Zilbauer, Jessica L. Forbester, Judith Kraiczy, Eve L. Coomber, Subhankar Mukhopadhyay, David Goulding, Robert E. W. Hancock, Fiona Powrie, Trevor D. Lawley, Holm H. Uhlig, Sally Forrest, Amy T. Y. Yeung, Simon Clare, Gordon Dougan, Anneliese O. Speak, Emily A. Lees
Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence that IL-22 primed intest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88142280f9f2cec0b9ae021e02a233df
Autor:
Jessica L, Forbester, Emily A, Lees, David, Goulding, Sally, Forrest, Amy, Yeung, Anneliese, Speak, Simon, Clare, Eve L, Coomber, Subhankar, Mukhopadhyay, Judith, Kraiczy, Fernanda, Schreiber, Trevor D, Lawley, Robert E W, Hancock, Holm H, Uhlig, Matthias, Zilbauer, Fiona, Powrie, Gordon, Dougan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We generated intestinal organoids from stem cells from a patient with infantile inflammatory bowel disease harboring a homozygous loss-of-function variant in the IL10RB gene, leaving the patient’s cells unable to respond to interleukin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d817a45d09d7a6d9af269a41620fa2c7
https://pubmed.ncbi.nlm.nih.gov/30217896
https://pubmed.ncbi.nlm.nih.gov/30217896