Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

Autor: Poulomi Banerjee, Arpan R. Mehta, Raja S. Nirujogi, James Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R. Alessi, Bhuvaneish T. Selvaraj, Josef Priller, Siddharthan Chandran

Publikováno v: Science advances 9(16), eabq0651 (2023). doi:10.1126/sciadv.abq0651
Banerjee, P, Mehta, A, Nirujogi, R S, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, McDade, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D R, Thangaraj Selvaraj, B, Priller, J & Chandran, S 2023, ' Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration ', Science Advances . https://doi.org/10.1126/sciadv.abq0651

Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell–derived microglia-like cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe9b8361917d07a830b67f50046784
https://pub.dzne.de/record/257688

Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells

Autor: Amy F. Lloyd, Emma M. Perkins, Josef Priller, Boyd Kenkhuis, David Story, Siddharthan Chandran, Owen Dando, Xin He, Evdokia Paza, Karen Burr, Poulomi Banerjee, Owen G. James, Rolf Backofen, Dilmurat Yusuf

Publikováno v: Banerjee, P, Paza, E, Perkins, E M, James, O G, Kenkhuis, B, Lloyd, A F, Burr, K, Story, D, Yusuf, D, He, X, Backofen, R, Dando, O, Chandran, S & Priller, J 2020, ' Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells ', Stem Cell Research, vol. 49, 102046 . https://doi.org/10.1016/j.scr.2020.102046
Stem Cell Research, Vol 49, Iss, Pp 102046-(2020)
Stem cell research 49, 102046 (2020). doi:10.1016/j.scr.2020.102046

Microglia are resident tissue macrophages of the central nervous system (CNS) that arise from erythromyeloid progenitors during embryonic development. They play essential roles in CNS development, homeostasis and response to disease. Since microglia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a7ad277ce5fb4e57e907ecbb752ab1
https://hdl.handle.net/20.500.11820/7748dc54-e64d-44b4-83b4-f2fdf94e8e60

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Autor: Rainer Glauben, Josef Priller, Anniki Knop, Stephan Schlickeiser, Eike Jakob Spruth, Désirée Kunkel, Lot de Witte, René S. Kahn, Elly M. Hol, G. Snijders, Chotima Böttcher, Evdokia Paza, Larissa Kraus, Henrik E. Mei, Axel R. Schulz, Marjolein A. M. Sneeboer, Pawel Fidzinski, Britta Siegmund

Publikováno v: Nature Neuroscience, 22(1), 78. Nature Publishing Group
Nature reviews / Neuroscience 22(1), 78-90 (2018). doi:10.1038/s41593-018-0290-2
Nature Neuroscience, 22, 78-90. Nature Publishing Group
Böttcher, C, Schlickeiser, S, Sneeboer, M A M, Kunkel, D, Knop, A, Paza, E, Fidzinski, P, Kraus, L, Snijders, G J L, Kahn, R S, Schulz, A R, Mei, H E, Hol, E M, Siegmund, B, Glauben, R, Spruth, E J, De Witte, L D & Priller, J 2019, ' Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry ', Nature Neuroscience, vol. 22, no. 1, pp. 78-90 . https://doi.org/10.1038/s41593-018-0290-2
Nature Neuroscience

Microglia, the specialized innate immune cells of the CNS, play crucial roles in neural development and function. Different phenotypes and functions have been ascribed to rodent microglia, but little is known about human microglia (huMG) heterogeneit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43be16e32de10a4c8f1414a76314ee90
https://doi.org/10.1038/s41593-018-0290-2