Výsledky vyhledávání - "Evans D. Pope"

Critical Appraisal of Amyloid Lowering Agents in AD

Autor: Zoltan Mari, Evans D. Pope, Jiong Shi, Boris Decourt, Fadel Boumelhem, Marwan N. Sabbagh

Publikováno v: Current Neurology and Neuroscience Reports

Purpose of Review According to the amyloid cascade hypothesis, removing amyloid beta (Aβ) should cure Alzheimer’s disease (AD). In the past three decades, many agents have been tested to try to lower Aβ production, prevent Aβ aggregation, and di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff831796b5a37f1ed391d772e5c861ce
http://europepmc.org/articles/PMC8192384

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Dementia with Lewy bodies: emerging drug targets and therapeutics

Autor: Zoltan Mari, Boris Decourt, Laura Cordes, Jiong Shi, Marwan N. Sabbagh, Evans D. Pope

Publikováno v: Expert Opin Investig Drugs

INTRODUCTION: Dementia with Lewy bodies (DLB) is characterized by the toxic accumulation of α-synuclein protein inside neural cells; this results in neurodegeneration which is clinically accompanied by behavioral and psychological changes. DLB share

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1cdbf6d80e4fede24283ea5bb387a7
https://pubmed.ncbi.nlm.nih.gov/33899637

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Therapeutic considerations for APOE and TOMM40 in Alzheimers disease: A tribute to Allen Roses MD

Autor: Evans D. Pope, Boris Decourt, Marwan N. Sabbagh, Laura Cordes, Jiong Shi

Publikováno v: Expert Opin Investig Drugs

Introduction: Four years ago this Autumn, pioneering neurologist Prof. Allen. D. Roses passed away. Hence, we have taken time to reflect on his work and legacy in Alzheimer's disease (AD) research. Prof. Roses rejected the widely accepted amyloid hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7fc646593c0700d448e51fabbe47f8
https://europepmc.org/articles/PMC9262379/

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Aberrant lipid metabolism as a therapeutic target in liver cancer

Autor: Kabir Mody, Evans D. Pope, Phani Keerthi Surapaneni, John A. Copland, Lalitha Padmanabha Vemireddy, ErinMarie O. Kimbrough

Publikováno v: Expert opinion on therapeutic targets. 23(6)

INTRODUCTION: Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers. Progress has been made in treatment of HCC; however, improved outcomes are much needed. The increased metabolic needs of cancer cells underscore the importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42da63a28edad6e572cf58a193f67fe5
https://pubmed.ncbi.nlm.nih.gov/31076001

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