Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Evangelos Pazarentzos"'
Autor:
Evangelos Pazarentzos
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activi
Externí odkaz:
https://doaj.org/article/2f60374e2f004965a9c764ca933216c5
Autor:
Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K. Mayekar, Philippe Gui, David V. Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R. Johnson, Matan Hofree, Jenny J. Yan, Billy W. Newton, John V. Dollen, Charles H. Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh Asthana, Trey Ideker, Wei Wu, Junji Suzuki, Benjamin A. Barad, Yuriy Kirichok, James S. Fraser, William A. Weiss, Nevan J. Krogan, Asmin Tulpule, Amit J. Sabnis, Trever G. Bivona
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2317-2330.e8 (2019)
Summary: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene
Externí odkaz:
https://doaj.org/article/83f131016a464f1dbca868c93b137b5a
Autor:
Collin M. Blakely, Evangelos Pazarentzos, Victor Olivas, Saurabh Asthana, Jenny Jiacheng Yan, Irena Tan, Gorjan Hrustanovic, Elton Chan, Luping Lin, Dana S. Neel, William Newton, Kathryn L. Bobb, Timothy R. Fouts, Jeffrey Meshulam, Matthew A. Gubens, David M. Jablons, Jeffrey R. Johnson, Sourav Bandyopadhyay, Nevan J. Krogan, Trever G. Bivona
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 98-110 (2015)
Although oncogene-targeted therapy often elicits profound initial tumor responses in patients, responses are generally incomplete because some tumor cells survive initial therapy as residual disease that enables eventual acquired resistance. The mech
Externí odkaz:
https://doaj.org/article/ef5b87cae72d408cae3fff714a029c60
Autor:
Evangelos Pazarentzos
Publikováno v:
Mol Cell Oncol
IκΒα (the protein product of NFKBIA gene) has widely been considered a pro-apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caee4ea0362e5703a501d6a29dccd9bb
https://pubmed.ncbi.nlm.nih.gov/35419474
https://pubmed.ncbi.nlm.nih.gov/35419474
Autor:
Matan Hofree, Yuriy Kirichok, Trey Ideker, Amit J. Sabnis, Benjamin A Barad, Victor Olivas, Luping Lin, Charles H. Earnshaw, Philippe Gui, Nevan J. Krogan, Billy W. Newton, Asmin Tulpule, Manasi K. Mayekar, Elton Chan, Wei Wu, Evangelos Pazarentzos, Trever G. Bivona, Erik Verschueren, Jenny Jiacheng Yan, James S. Fraser, Saurabh Asthana, David V. Allegakoen, Nilanjana Chatterjee, John Von Dollen, William A. Weiss, Junji Suzuki, Gorjan Hrustanovic, Jeffrey R. Johnson, Jennifer Flanagan
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2317-2330.e8 (2019)
Cell reports, vol 28, iss 9
Cell reports, vol 28, iss 9
Summary: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79e374b70d7e1cfafcce37c90064549
http://www.sciencedirect.com/science/article/pii/S2211124719309672
http://www.sciencedirect.com/science/article/pii/S2211124719309672
Autor:
Luping Lin, William A. Weiss, Junji Suzuki, Matan Hofree, Jennifer Flanagan, Trey Ideker, Billy W. Newton, Nevan J. Krogan, John Von Dollen, Gorjan Hrustanovic, Nilanjana Chatterjee, Wei Wu, James S. Fraser, Trever G. Bivona, Amit J. Sabnis, Saurabh Asthana, Evangelos Pazarentzos, Asmin Tulpule, Manasi K. Mayekar, Benjamin A Barad, Elton Chan, Victor Olivas, Charles H. Earnshaw, Jenny Jiacheng Yan, Erik Verschueren, Jeffrey R. Johnson, Yuriy Kirichok
SUMMARYPTEN is a tumor suppressor that is often inactivated in cancer and possesses both lipid and protein phosphatase activities. We report the metabolic regulator PDHK1 (pyruvate dehydrogenase kinase1) is a synthetic-essential gene in PTEN-deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118076cd14e1ddf5bd32cd3fb4e7f951
https://doi.org/10.1101/441295
https://doi.org/10.1101/441295
Autor:
Matthew A. Gubens, Petros Giannikopoulos, Gorjan Hrustanovic, Trever G. Bivona, Evangelos Pazarentzos, Victor Olivas, R Balassanian, J St John, Jonathan S. Weissman, William R. Polkinghorn
Publikováno v:
Oncogene. 35:1198-1205
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers. Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN are known to drive PI3K pathway activation and cancer growth, the significance of somatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12f02271f56ed5b4b84e423526d3553
https://doi.org/10.1038/onc.2015.173
https://doi.org/10.1038/onc.2015.173
Publikováno v:
Oncogene. 34:5599-5606
The identification of specific genetic alterations that drive the initiation and progression of cancer and the development of targeted drugs that act against these driver alterations has revolutionized the treatment of many human cancers. Although su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3772b4b15e2fb89e5711e1acfbcbb63b
https://doi.org/10.1038/onc.2015.26
https://doi.org/10.1038/onc.2015.26
Autor:
Antonio Marchetti, Dana S. Neel, Zachary A. Cooper, Eric A. Collisson, Trever G. Bivona, Keith T. Flaherty, Charles M. Rudin, Jose Luis Ramirez, Eric Robinson, Amit J. Sabnis, Niki Karachaliou, Jose M. Torres, Javier Cortes, Saurabh Asthana, Luping Lin, Jose Luis Manzano, Evangelos Pazarentzos, Eva Muñoz-Couselo, Jennifer A. Wargo, Mingxue M Wang, Lindsay Cade, Maria Gonzalez Cao, Fiamma Buttitta, Dennie T. Frederick, Iman Osman, Elton Chan, Alain Algazi, Rafael Rosell, Xinyuan Lu, Martin McMahon, Jenny Jiacheng Yan, Victor Olivas, Luu Pham
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Resistance to RAF- and MEK-targeted therapy is a major clinical challenge1–4. RAF and MEK inhibitors are initially but only transiently effective in some but not all patients with BRAF gene mutation and are largely ineffective in those with RAS gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ef59d2d16e059f9ee56ce01c100574
https://doi.org/10.1038/ng.3218
https://doi.org/10.1038/ng.3218
Autor:
John Doyle, Saurabh Asthana, Vanessa D. Jonsson, Barry S. Taylor, Matthew A. Gubens, Luping Lin, Victor Olivas, Boris C. Bastian, Evangelos Pazarentzos, Trever G. Bivona, Collin M. Blakely, Nikolai Matni
Publikováno v:
Scientific reports, vol 7, iss 1
Jonsson, VD; Blakely, CM; Lin, L; Asthana, S; Matni, N; Olivas, V; et al.(2017). Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution. Scientific Reports, 7, 44206. doi: 10.1038/srep44206. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0qh1h9wn
Scientific Reports
Jonsson, VD; Blakely, CM; Lin, L; Asthana, S; Matni, N; Olivas, V; et al.(2017). Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution. Scientific Reports, 7, 44206. doi: 10.1038/srep44206. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0qh1h9wn
Scientific Reports
The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42abae747d6a6ed193b3d4e3faf0bc55