Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Evangelos D. Karousis"'
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins. A
Externí odkaz:
https://doaj.org/article/d9b65df3d2c44430a7ca1c596f183936
Autor:
Evangelos D. Karousis, Lukas-Adrian Gurzeler, Giuditta Annibaldis, René Dreos, Oliver Mühlemann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is no
Externí odkaz:
https://doaj.org/article/e2ad888a263f4904912b1414bd2a56cf
Publikováno v:
Trends in Biochemical Sciences. 47:921-935
Nonsense-mediated mRNA decay (NMD) serves as a quality control mechanism by degrading mRNAs with premature termination codons (PTCs), and it also regulates the abundance of physiological RNAs encoding functional proteins. Recent work showed that NMD
Publikováno v:
Gurzeler, Lukas-Adrian; Ziegelmüller, Jana; Mühlemann, Oliver; Karousis, Evangelos D. (2022). Production of human translation-competent lysates using dual centrifugation. RNA biology, 19(1), pp. 78-88. Taylor and Francis 10.1080/15476286.2021.2014695
RNA Biology
article-version (VoR) Version of Record
RNA Biology
article-version (VoR) Version of Record
Protein synthesis is a central process in gene expression and the development of efficient in vitro translation systems has been the focus of scientific efforts for decades. The production of translation-competent lysates originating from human cells
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96557 (2014)
Subtle alternative splicing leads to the formation of RNA variants lacking or including a small number of nucleotides. To date, the impact of subtle alternative splicing phenomena on protein biosynthesis has been studied in frame-preserving incidents
Externí odkaz:
https://doaj.org/article/ba9a04c1ce5a4e34b2782bb1352653c4
Autor:
Blanca Echeverria, Katharina Schubert, Volker Thiel, Alain Scaiola, Evangelos D. Karousis, Lukas Adrian Gurzeler, Marc Leibundgut, Ahmad Jomaa, Nenad Ban, Oliver Mühlemann
Publikováno v:
Nature Structural & Molecular Biology
Autor:
Alain Scaiola, Oliver Mühlemann, Marc Leibundgut, Ahmad Jomaa, Volker Thiel, Evangelos D. Karousis, Blanca Echeverria, Lukas Adrian Gurzeler, Katharina Schubert, Nenad Ban
Publikováno v:
Nature Structural & Molecular Biology, 27 (10)
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology
The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, suppresses host innate immune functions. By combining cryo-electron microscopy and biochemistry, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf8f76b79e2c4e1da2e331cee3349d6
https://hdl.handle.net/20.500.11850/443711
https://hdl.handle.net/20.500.11850/443711
Autor:
Marc Leibundgut, Katharina Schubert, Blanca Echeverria, Lukas-Adrian Gurzeler, Ahmad Jomaa, Oliver Mühlemann, Alain Scaiola, Volker Thiel, Evangelos D. Karousis, Nenad Ban
The non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, is the first viral protein that is synthesized in SARS-CoV-2 infected human cells to suppress host innate immune functions1,2. By combining cryo-electron microscopy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7459080da4e69e610c0c519418334928
https://doi.org/10.1101/2020.07.07.191676
https://doi.org/10.1101/2020.07.07.191676
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 7:661-682
Nonsense-mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. Meanwhile, it became clear that NMD has a much