scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T

Autor: Kyle J, Gellatly, James P, Strassner, Kingsley, Essien, Maggi Ahmed, Refat, Rachel L, Murphy, Anthony, Coffin-Schmitt, Amit G, Pandya, Andrea, Tovar-Garza, Michael L, Frisoli, Xueli, Fan, Xiaolan, Ding, Evangeline E, Kim, Zainab, Abbas, Patrick, McDonel, Manuel, Garber, John E, Harris

Publikováno v: Sci Transl Med

Vitiligo is an autoimmune skin disease characterized by the targeted destruction of melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in CD8+ T cell infiltration of vitiligo lesions, but the full scope of signals re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35696854ae7a1a54611a50533fe32e04
https://pubmed.ncbi.nlm.nih.gov/34516831

Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease.

Autor: Shakiba S; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Haddadi NS; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Afshari K; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Lubov JE; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Raef HS; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Li R; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Yildiz-Altay Ü; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Daga M; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Refat MA; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Kim E; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., de Laflin JG; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Akabane A; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Sherman S; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., MacDonald E; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Strassner JP; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Zhang L; NanoString Technologies, Seattle, WA, USA., Leon M; NanoString Technologies, Seattle, WA, USA., Baer CE; UMass Chan Medical School, Sanderson Center for Optical Experimentation, Dept of Microbiology and Physiological Systems, Worcester, MA, USA., Dresser K; UMass Chan Medical School, Dept of Pathology, Worcester, MA, USA., Liang Y; NanoString Technologies, Seattle, WA, USA., Whitley JB; Dartmouth Hitchcock Medical Center, Dept of Medicine, Lebanon, NH, USA., Skopelja-Gardner S; Dartmouth Hitchcock Medical Center, Dept of Medicine, Lebanon, NH, USA., Harris JE; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Deng A; UMass Chan Medical School, Dept of Pathology, Worcester, MA, USA., Vesely MD; Yale University School of Medicine, Dept of Dermatology, New Haven, CT, USA., Rashighi M; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA., Richmond J; UMass Chan Medical School, Dept of Dermatology, Worcester, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 06. Date of Electronic Publication: 2024 Jan 06.