Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Evangelia Loizou"'
Autor:
Scott W. Lowe, Benjamin H. Durham, Edward R. Kastenhuber, Frederik O. Bagger, Savvas Kinalis, Chi-Chao Chen, Allison Mayle, Francisco J. Sánchez-Rivera, Richard P. Koche, Yu-Jui Ho, Geulah Livshits, Ana Banito, Evangelia Loizou
Supplementary Figures S1-S8, with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1496c995e76a3726761c3a9759b492df
https://doi.org/10.1158/2159-8290.22536263.v1
https://doi.org/10.1158/2159-8290.22536263.v1
Autor:
Scott W. Lowe, Benjamin H. Durham, Edward R. Kastenhuber, Frederik O. Bagger, Savvas Kinalis, Chi-Chao Chen, Allison Mayle, Francisco J. Sánchez-Rivera, Richard P. Koche, Yu-Jui Ho, Geulah Livshits, Ana Banito, Evangelia Loizou
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf67a1b83a91ffbeefd1c5974a2de38
https://doi.org/10.1158/2159-8290.22536260
https://doi.org/10.1158/2159-8290.22536260
Autor:
Scott W. Lowe, Benjamin H. Durham, Edward R. Kastenhuber, Frederik O. Bagger, Savvas Kinalis, Chi-Chao Chen, Allison Mayle, Francisco J. Sánchez-Rivera, Richard P. Koche, Yu-Jui Ho, Geulah Livshits, Ana Banito, Evangelia Loizou
Sequence of oligos and plasmids used as well as FACS antibody details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee38d2005e5b970150ec1a8371e69ad
https://doi.org/10.1158/2159-8290.22536257
https://doi.org/10.1158/2159-8290.22536257
Autor:
Evangelia Loizou, Chi-Chao Chen, Allison Mayle, Geulah Livshits, Richard Koche, Benjamin H. Durham, Edward R. Kastenhuber, Francisco J. Sánchez-Rivera, Ana Banito, Savvas Kinalis, Frederik Otzen Bagger, Yu-Jui Ho, Scott W. Lowe
Publikováno v:
Cancer Discov
Mutations in the TP53 tumor suppressor gene are common in many cancer types, including the acute myeloid leukemia (AML) subtype known as complex karyotype AML (CK-AML). Here, we identify a gain-of-function (GOF) Trp53 mutation that accelerates CK-AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e296708bf88a4a3eb83ecba88e09a90c
https://europepmc.org/articles/PMC6606372/
https://europepmc.org/articles/PMC6606372/
Autor:
Lingbo Zhang, Sara Violante, John P. Morris, Scott E. Millman, Xiang Li, Allison Mayle, Hardik Shah, Scott W. Lowe, Yu-Jui Ho, Evangelia Loizou, Chi-Chao Chen, Weige Qin, Justin R. Cross, Cynthia Chen, Hui Liu, Bo Li
Publikováno v:
Cancer Cell
Summary Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK—an enzyme that produces pyridoxal phosphate (PLP) from vitamin B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a92d30287299c6a47d599bde5254067
https://pubmed.ncbi.nlm.nih.gov/32610066
https://pubmed.ncbi.nlm.nih.gov/32610066
Autor:
Maria E. Arcila, Friederike Pastore, Ross L. Levine, Stefan Kubicek, Andrei V. Krivtsov, Lennart Bastian, Alan Chramiec, Daniel Tovbin, Abby R. Weinstein, Mithat Gönen, Adriana Rodriguez Gonzalez, Yen K. Lieu, Jacob M. Rowe, Luisa Luciani, Christopher E. Mason, Richard Koche, Omar Abdel-Wahab, Kaitlyn Shank, Justin R. Cross, Siddhartha Mukherjee, Stephen D. Nimer, Benjamin H. Durham, Wolfgang R. Sperr, Abhinita Mohanty, Olga A. Guryanova, Evangelia Loizou, Elodie Pronier, Barbara Spitzer, Scott A. Armstrong, Gregor Hoermann, Francine E. Garrett-Bakelman, Anna Sophia McKenney, Elisabeth Paietta, Martin S. Tallman, Philipp B. Staber, Matthew D. Keller, Ari Melnick, Sharon A. Rivera, Chezi Ganzel
Publikováno v:
Nature Medicine. 22:1488-1495
Although the majority of patients with acute myeloid leukemia (AML) initially respond to chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML persistence following chemotherapy has not been determined. Recurrent somatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c7ac432a91e673cc2fff05a53fd820
https://doi.org/10.1038/nm.4210
https://doi.org/10.1038/nm.4210
Autor:
Ryan G. Kruger, Hugh Y. Rienhoff, Evangelia Loizou, Scott A. Armstrong, Britta Will, Min Ye, Ross L. Levine, Alan Chramiec, Helai P. Mohammad, Andrei V. Krivtsov, Matthew Witkin, Daniel G. Tenen, Sheng F. Cai, Richard Koche, Monica Cusan, Ulrich Steidl, Kimberly N. Smitheman
Publikováno v:
Blood. 131(15)
Epigenetic regulators are recurrently mutated and aberrantly expressed in acute myeloid leukemia (AML). Targeted therapies designed to inhibit these chromatin-modifying enzymes, such as the histone demethylase lysine-specific demethylase 1 (LSD1) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105949f675f6e4aed8cc77d5adbc0b54
https://pubmed.ncbi.nlm.nih.gov/29453291
https://pubmed.ncbi.nlm.nih.gov/29453291
Autor:
Emily I. Chen, Evangelia Loizou, Konrad Hochedlinger, Alexandros Strikoudis, Effie Apostolou, Charles Farnsworth, Iannis Aifantis, Beatriz Aranda-Orgilles, Ramanuj DasGupta, Jeffrey C. Silva, Matthias Stadtfeld, Antonius Koller, Kelly Moran-Crusio, Shannon Buckley
Publikováno v:
Cell Stem Cell. 11(6):783-798
SummaryAlthough transcriptional regulation of stem cell pluripotency and differentiation has been extensively studied, only a small number of studies have addressed the roles for posttranslational modifications in these processes. A key mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9fb1c1f2bf825364a216c6b339d3f5
Autor:
Hanna K. A. Mikkola, Sherif Ibrahim, Anastasia N. Tikhonova, Iannis Aifantis, Spyros Artavanis-Tsakonas, Jie Gao, Ben Van Handel, Philmo Oh, Camille Lobry, Evangelia Loizou, Jeffrey Greve, Jan Manent
SummaryAccumulating evidence suggests that Notch signaling is active at multiple points during hematopoiesis. Until recently, the majority of such studies focused on Notch signaling in lymphocyte differentiation and knowledge of individual Notch rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7feafab3622384ca67ba556b76c628
https://europepmc.org/articles/PMC3902172/
https://europepmc.org/articles/PMC3902172/
Autor:
Ross L. Levine, Luisa Luciani, Evangelia Loizou, Omar Abdel-Wahab, Olga A. Guryanova, Kaitlyn Shank, Matthew D. Keller, Stephen S. Nimer, Abby R. Weinstein, Siddhartha Mukherjee
Publikováno v:
Cancer Research. 74:44-44
Despite significant advances in cancer research and treatment, therapeutic resistance remains a major obstacle for achieving stable remission in cancer patients. Acute myeloid leukemia (AML) is no exception, and most AML patients develop resistance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881b4eb0839e30ec44a5dd40c7618b9b
https://doi.org/10.1158/1538-7445.cansusc14-44
https://doi.org/10.1158/1538-7445.cansusc14-44