Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Evangelia Kokalaki"'
Autor:
Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches.
Externí odkaz:
https://doaj.org/article/0a0cba1c19b24f4e8e75069f7a2b0924
Autor:
Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitor
Externí odkaz:
https://doaj.org/article/e38d52e6c99944609c3459b7f08fd187
Autor:
Matteo Righi, Isaac Gannon, Matthew Robson, Saket Srivastava, Evangelia Kokalaki, Thomas Grothier, Francesco Nannini, Christopher Allen, Bai Yuchen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule
Adoptive T cell therapy aims to achieve lasting tumour clearance, requiring enhanced engraftment and survival of the immune cells. Cytokines are paramount modulators of T cell survival and proliferation. Cytokine receptors signal via ligand-induced d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae538a8aeb70545cbc317a68414ee38
https://doi.org/10.1101/2023.04.24.538039
https://doi.org/10.1101/2023.04.24.538039
Autor:
Evangelia Kokalaki, Biao Ma, Mathieu Ferrari, Thomas Grothier, Warren Hazelton, Somayya Manzoor, Eren Costu, Julia Taylor, Anna Bulek, Saket Srivastava, Isaac Gannon, Ram Jha, Rosalind Gealy, Lukas Stanczuk, Tatiana Rizou, Mathew Robson, Mohamed El-Kholy, Vania Baldan, Matteo Righi, James Sillibourne, Simon Thomas, Shimobi Onuoha, Shaun Cordoba, Martin Pule
Publikováno v:
Molecular Therapy.
Autor:
Valeria Fiaccadori, Morgan J. Palton, Evangelia Kokalaki, Shaun Cordoba, Harriet Roddy, Shimobi Onuoha, Gordon Cheung, Iwan P. Williams, Claire Roddie, Alastair Hotblack, Giulia Agliardi, Thomas Grothier, Martin Pule, Patrycja Wawrzyniecka, Somayya Manzoor, Simon Thomas, Alice Piapi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signalin
Autor:
Lorenzo Biassoni, Julie Silvester, Jack Barton, Claire Barton, Muhammad Al-Hajj, Clare Marriott, Talia Gileadi, Thalia Loka, John Anderson, Simon Thomas, Karin Straathof, Stephanie Traub, Sarah Inglott, Lesley Robson, Evangelia Kokalaki, Giuseppe Barone, Kieran McHugh, Lily Elson, Karen Dyer, Karen Howe, Sarita Depani, Teresa Marafioti, Ami Bedi, Natalie Sizer, Sian Stafford, Nigel Westwood, Olumide Ogunbiyi, Gordon Weng-Kit Cheung, Barry Flutter, Sue Brook, Martin Pule, Dyanne Rampling, Gary Wright, Kimberly Gilmour, Rebecca Wallace, Catriona Duncan, David P. Edwards, Ailish Barry, William Day, Neha Jain, Ilaria Dragoni, Ayse U. Akarca
Publikováno v:
Science Translational Medicine. 12
The reprogramming of a patient’s immune system through genetic modification of the T cell compartment with chimeric antigen receptors (CARs) has led to durable remissions in chemotherapy-refractory B cell cancers. Targeting of solid cancers by CAR-
Autor:
Thomas Grothier, Shimobi Onuoha, Biao Ma, Somayya Manzoor, Martin Pule, Shaun Cordoba, Evangelia Kokalaki, Eren Costu, Ram Jha, Warren Hazelton, Simon Thomas
Publikováno v:
Blood. 134:5747-5747
Background: CD22 is an attractive target for Chimeric Antigen Receptor (CAR) since it is expressed by most B-cell malignancies. However, CAR targeting of CD22 is challenging since CD22 has a long ectodomain of 300 Å, which is several times wider tha
Autor:
Karl S. Peggs, Simon Thomas, Karin Straathof, Evangelia Kokalaki, Barry Flutter, Ronjon Chakraverty, Teresa Marafioti, Virna Marin, David C. Linch, Leila Mekkaoui, Martin Pule, Brian Philip, Sergio A. Quezada
Publikováno v:
Blood. 124:1277-1287
A compact marker/suicide gene that utilizes established clinical-grade reagents and pharmaceuticals would be of considerable practical utility to T-cell cancer gene therapy. Marker genes enable measurement of transduction and allow selection of trans
Autor:
Simon Thomas, Martin Pule, Evangelia Kokalaki, Daria Galas-Filipowicz, Brian Philip, Neil Chaplin, Melody Chin, Lydia Lee, Kwee Yong, James Francis, Benjamin Draper
Publikováno v:
Blood. 128:379-379
Immune based strategies have shown early promise in multiple myeloma (MM), and are likely to prove a valuable addition to the therapeutic platforms for these patients. B cell maturation antigen (BCMA) is a promising therapeutic target with selective