Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Evangelia K. Ttofi"'
Autor:
Sean Tenant, Evangelia K. Ttofi, Claire H. Michel, David C. Rubinsztein, Matthieu Y. Pasco, Cahir J. O'Kane, Zdenek Berger
Publikováno v:
Human Molecular Genetics. 14:3003-3011
We have previously shown that lithium can protect against the polyglutamine toxicity of the Huntington's disease mutation in cell models. Here, we demonstrate for the first time in vivo that lithium can protect against the toxicity caused by aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce5c4310bfff772fd7e2ded53f22984
https://doi.org/10.1093/hmg/ddi331
https://doi.org/10.1093/hmg/ddi331
Autor:
Chien-Wen Chen, Sara Imarisio, Janet E. Davies, Benjamin R. Underwood, Shinji Saiki, Evangelia K. Ttofi, Jenny Carmichael, David C. Rubinsztein, Gauri Krishna, Viktor I. Korolchuk, Claudia Rose
Publikováno v:
The Biochemical journal. 412(2)
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease caused by a CAG trinucleotide repeat expansion encoding an abnormally long polyglutamine tract in the huntingtin protein. Much has been learnt since the mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70797beca0c2f5abe97aeed2054659fd
https://pubmed.ncbi.nlm.nih.gov/18466116
https://pubmed.ncbi.nlm.nih.gov/18466116
Autor:
Angeleen Fleming, David C. Rubinsztein, Andrea Williams, R.A. Floto, Cahir J. O'Kane, Paul Cuddon, Shinji Saiki, Luca Jahreiss, Dean Pask, Evangelia K. Ttofi, Sovan Sarkar, Paul Goldsmith, Farah H. Siddiqi
Autophagy is a major clearance route for intracellular aggregate-prone proteins causing diseases such as Huntington's disease. Autophagy induction with the mTOR inhibitor rapamycin accelerates clearance of these toxic substrates. As rapamycin has non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e43282b638402c45c2b7b586f00e84
https://europepmc.org/articles/PMC2635566/
https://europepmc.org/articles/PMC2635566/
